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Chemistry
; 25(27): 6722-6727, 2019 May 10.
Article
in English
| MEDLINE
| ID: mdl-30801812
ABSTRACT
A straightforward glycosylation method is described to regio- and stereoselectively introduce two α-l-fucose moieties directly to the secondary rim of ß-cyclodextrin. Using NMR and MS fragmentation studies, the nonasaccharide structure was determined, which was also visualized using molecular dynamics simulations. The reported glycosylation method proved to be robust on gram-scale, and may be generally applied to directly glycosylate ß-cyclodextrins to make well-defined multivalent glycoclusters.