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Antiviral, antibacterial and antitumor activity of the hydrazide and the ethyl ester of 2,2'-anhydro-1-(beta-D-arabinofuranosyl)-orotic acid.
Golovinsky, E; Galabov, A S; Stankevich, E Y; Karparov, A; Maneva, L; Grancharov, K; Chakova, N; Sniker, D Y; Angelov, I; Velichkova, E.
Arzneimittelforschung ; 30(12): 2087-90, 1980.
Article in English | MEDLINE | ID: mdl-7011329

ABSTRACT

It has been demonstrated that the hydrazide and the ethyl ester of 2,2'-anhydro-1-(beta-D-arabinofuranosyl) orotic acid inhibit selectively the multiplication of some DNA-containing viruses (PsRV, VV, AdV5), suppress the growth of E. coli and St. aureus in vitro and exhibit an antitumor effect with Lewis lung carcinoma and sarcoma 298.


Subject(s)
Arabinonucleosides/pharmacology , Bacteria/drug effects , DNA Viruses/drug effects , Neoplasms, Experimental/drug therapy , Animals , Chick Embryo , Escherichia coli/drug effects , Lung Neoplasms/drug therapy , Male , Mice , Mice, Inbred C57BL , Rats , Sarcoma, Experimental/drug therapy , Staphylococcus aureus/drug effects
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