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1.
J Nat Prod ; 70(10): 1578-81, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17892263

ABSTRACT

The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A-F ( 1- 6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 ( 7, 8) additionally lack the epoxide group on C-4 and C-5.


Subject(s)
Actinomycetales/chemistry , Anti-Bacterial Agents/isolation & purification , Maytansine/analogs & derivatives , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/classification , Anti-Bacterial Agents/pharmacology , Ascomycota/drug effects , Maytansine/chemistry , Maytansine/classification , Maytansine/isolation & purification , Maytansine/pharmacology , Molecular Structure , Structure-Activity Relationship
2.
Bioorg Med Chem ; 13(21): 6009-14, 2005 Nov 01.
Article in English | MEDLINE | ID: mdl-16125394

ABSTRACT

Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids, humirianthone 1, 1-hydroxy-humirianthone 2, 15R-humirianthol 3, patagonol 4, and patagonal 5, and the five known diterpenoids, humirianthol 7, annonalide 8, acrenol 9, icacinol 10, and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line, and compounds 1, 3, 8, and 9 also showed activity against phytopathogenic fungi.


Subject(s)
Diterpenes/isolation & purification , Diterpenes/toxicity , Plants, Medicinal/chemistry , Antifungal Agents/chemistry , Antifungal Agents/isolation & purification , Antifungal Agents/pharmacology , Antifungal Agents/toxicity , Cell Line, Tumor , Cell Proliferation/drug effects , Diterpenes/chemistry , Diterpenes/pharmacology , Fungi/drug effects , Fungi/physiology , Humans , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Rain , Suriname , Trees
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