ABSTRACT
Insulin binding by erythroid cells of newborn and 1-, 10-, 30-days pigs was investigated. The process intensity in piglets was found to decline in the period from birth to 30 days of life. The obtained changes were determined by the reduced receptors number in high affinity site in early postnatal ontogenesis as well as by decrease of receptor affinity constants in 30-days animals. During investigated period the level of insulin binding by erythrocytes was conditioned by hormone binding ability of "young" erythroid cells, which was found to be high in newborn and decreased considerably in 10-30 days pigs. It was established that postnatal decrease of insulin binding by erythrocytes occurred simultaneously with sharp increase of insulin concentration in animal during the 10-days period after birth. So, it is supposed that insulin may be involved in regulation of its own receptor number in erythrocytes.
