ABSTRACT
OBJECTIVE: This study was performed to assess the sterility of multidose 99mTc generator eluate vials at the end of a working day. METHODS: Expired 99mTc generator eluate vials were collected over a period of 10 wk and stored until the activity reached background. Four batches of 10 vials each were selected randomly and sent to an independent microbiology laboratory for sterility testing. RESULTS: No eluate showed any microbial growth after 14 d incubation in growth media. CONCLUSION: Retrospective sterility testing of 99mTc generator eluate confirmed the validity of our departmental protocol for radiopharmaceutical preparation. Sterility testing has become part of our quality control program.
Subject(s)
Drug Contamination , Radiopharmaceuticals , Technetium , 2-Propanol/administration & dosage , Bacteria/growth & development , Disinfectants/administration & dosage , Disinfection/methods , Drug Contamination/prevention & control , Drug Storage , Equipment Contamination/prevention & control , Humans , Needles , Quality Control , Radiopharmaceuticals/standards , Retrospective Studies , Technetium/standards , Technology, Radiologic/instrumentation , Technology, Radiologic/standardsABSTRACT
OBJECTIVE: The purpose of this study was to demonstrate a fast, safe and simple method for preparing heat-damaged red blood cells. METHODS: Patient blood was radiolabeled using the Ultra-Tag RBC kit and then heated to 49.5 degrees C for 20 min. The reaction vial was cooled in ice water for 1 min and the required activity was administered to the patient. The patient was imaged 60 min postinjection. RESULTS: High-quality planar and SPECT images of the spleen were obtained with low background activity noted. Radiolabeling efficiency was greater than 95%. CONCLUSION: The method was safe and simple to perform. High-quality images of the spleen were obtained.
Subject(s)
Erythrocytes , Radiopharmaceuticals , Spleen/injuries , Splenic Infarction/diagnostic imaging , Technetium , Female , Hot Temperature , Humans , Image Enhancement , Middle Aged , Safety , Spleen/diagnostic imaging , Time Factors , Tomography, Emission-Computed, Single-PhotonSubject(s)
Benzodiazepines , Brain/diagnostic imaging , Epilepsy/diagnostic imaging , Animals , Benzodiazepinones/pharmacokinetics , Intestinal Absorption , Iodine Radioisotopes , Isotope Labeling , Male , Rats , Rats, Inbred Strains , Tissue Distribution , Tomography, Emission-Computed, Single-PhotonABSTRACT
Biodistributions of a series of thirteen 99mTc-o-hydroxy-benzyliminodiacetic acid complexes were carried out in rats and their hepatobiliary and urinary outputs correlated with lipophilicity, molecular weight, influence of substituent and plasma protein binding. Hepatobiliary output was moderate for those ligands with large alkyl substituents [t-butyl (36%), and iso-octyl (42%)] but compared to HIDA compounds was relatively low, indicating that they would not be suitable for clinical use. Halogen substituents had only a small effect on increasing hepatobiliary output but a large effect on reducing the urinary clearance.
