1.
Angew Chem Int Ed Engl
; 52(30): 7714-7, 2013 Jul 22.
Article
in English
| MEDLINE
| ID: mdl-23788494
ABSTRACT
It's the water that matters. Pairs of benzo- and perfluorobenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an enthalpy-driven binding, and indistinguishable binding affinities (see picture). These data support the pervasive theory that the lock-and-key model disregards an important component of binding: the water, which fills the binding pocket of the protein and surrounds the ligand.