1.
Antibiotiki
; 29(3): 179-82, 1984 Mar.
Article
in Russian
| MEDLINE
| ID: mdl-6428302
ABSTRACT
The stability of tylosin, a macrolide antibiotic, in solutions with varying pH and temperature was determined quantitatively. It was shown that tylosin was the most stable at pH about 3.5 and 9.0, which corresponded to the salt and nondissociated forms of the substance. Outside these stability ranges significant inactivation of the antibiotic was observed. The inactivation markedly increased with an increase in the temperature level and the exposure period. Satisfactory correlation between the data on microbiological and spectrophotometric determinations of tylosin in solutions is indicative of the advisability of the use of spectrophotometry in production of tylosin.
Subject(s)
Leucomycins/pharmacology , Bacillus subtilis/drug effects , Biological Assay , Drug Stability , Hydrogen-Ion Concentration , Leucomycins/analysis , Solutions , Spectrophotometry, Ultraviolet , Temperature
2.
Antibiotiki
; 18(5): 439-44, 1973 May.
Article
in Russian
| MEDLINE
| ID: mdl-4781215
3.
Antibiotiki
; 18(1): 11-5, 1973 Jan.
Article
in Russian
| MEDLINE
| ID: mdl-4685111
4.
Antibiotiki
; 16(8): 691-7, 1971.
Article
in Russian
| MEDLINE
| ID: mdl-5139443
5.
Antibiotiki
; 14(5): 407-12, 1969 May.
Article
in Russian
| MEDLINE
| ID: mdl-5785941
6.
Antibiotiki
; 13(2): 120-6, 1968 Feb.
Article
in Russian
| MEDLINE
| ID: mdl-5691820
Subject(s)
Streptomycin/biosynthesis , Surface-Active Agents/pharmacology , Ammonia/pharmacology , Calcium Carbonate/pharmacology , Culture Media , Fermentation , Flour , Glucose/pharmacology , Lactates/pharmacology , Phosphates , Plant Extracts/pharmacology , Potassium/pharmacology , Sodium Chloride/pharmacology , Glycine max , Starch , Sulfates , Temperature , Zea mays , Zinc/pharmacology
7.
Antibiotiki
; 12(8): 733-40, 1967 Aug.
Article
in Russian
| MEDLINE
| ID: mdl-4871880
8.
Med Prom SSSR
; 20(10): 47-50, 1966 Oct.
Article
in Russian
| MEDLINE
| ID: mdl-6000063
Subject(s)
Culture Media/analysis , Gases/analysis , Streptomycin/biosynthesis , Technology, Pharmaceutical , Air
9.
Med Prom SSSR
; 20(3): 22-7, 1966 Mar.
Article
in Russian
| MEDLINE
| ID: mdl-5985064