Proteinuria is associated with quality of life and depression in adults with primary glomerulopathy and preserved renal function.

BACKGROUND: There is no information about HRQoL, depression and associated factors in adult with nephrotic syndrome-associated glomerulopathy. METHODOLOGY/PRINCIPAL FINDINGS: Patients with primary glomerulopathy where compared with age and sex-matched hemodialysis patients and healthy subjects. Laboratory data, medical history, comorbid conditions were collected to evaluate factors associated with HRQoL (SF-36) and Depression (Hamilton Depression Rating Scale-HAMD). Glomerulopathy patients had low HRQoL in all eight SF-36 domains and two composite scores (physical and mental) in comparison with healthy subjects. HAMD score also was elevated and there was high depression prevalence. Overall, these data were comparable between glomerulopathy and hemodialysis patients. Using multiple regression analysis, factors associated with low HRQoL physical composite score were: last 24 h-urine protein excretion (-0.183, 95%CI -0.223 to -0.710 for each gram of proteinuria, p = 0.01) and cyclosporine use (-15.315, 95%CI -25.913 to -2.717, p = 0.03). Low HRQoL mental composite score was associated with last 24 h-urine protein excretion (-0.157, 95%CI -0.278 to -0.310 for each gram of proteinuria, p = 0.03) and HMAD score was independently associated with age (0.155, 95%CI 0.318 to 0.988 for each year, p = 0.04), female sex (4.788, 95%CI 1.005 to 8.620, 0 = 0.03), disease duration (0.074, 95%CI 0.021 to 0.128 for each month, p = 0.01) and last 24 h-urine protein excretion (0.050, 95%CI 0.018 to 0.085 for each gram of proteinuria, p = 0.02). CONCLUSIONS/SIGNIFICANCE: Nephrotic-syndrome associated glomerulopathy patients have low HRQoL and high prevalence of depression symptoms, comparable with those of hemodialysis patients. Last 24 h-protein excretion rate is independently associated with physical and mental HRQoL domains in addition to depression.

Percepção dos usuários acerca do aconselhamento pré-teste anti HIV em uma unidade de referência em Fortaleza, Ceará / User´s perception about anti-hiv pre-test couseling in a reference unit in Fortaleza, Ceará

O aconselhamento pré-teste anti-HIV é uma estratégia importante no campo do conhecimento, da prevenção e na qualidade do diagnóstico de HIV/aids e da atenção à saúde e tem como componentes o apoio educativo/informativo, emocional e a avaliação de riscos. Este estudo teve como objetivo conhecer a percepção dos usuários acerca do componente informativo do aconselhamento pré-teste em Fortaleza, Ceará. Estudo exploratório-descritivo, com abordagem qualitativa, realizado com treze usuários que participaram do aconselhamento pré-teste, em uma unidade de referência para DST. A coleta de dados ocorreu, no período de março a abril de 2007, por meio de entrevistas semi-estruturadas. Os dados foram organizados em categorias e a análise pautou-se no componente educativo/informativo do aconselhamento para DST/HIV/aids recomendado pelo Ministério da Saúde. Verificou-se que os usuários percebem a importância desse componente do aconselhamento pré-teste anti-HIV como estratégia preventiva, contribuindo sobremaneira para a autopercepção de riscos e vulnerabilidade e para a decisão em realizar o teste.

The pre-test counseling for anti-HIV is an important strategy in the field of knowledge, prevention and quality of diagnosis of HIV/aids, attention to health care, having as components the educational/informative, emotional support and evaluation of risks. This study had as main objective to know the perception of users. This study aimed to understand the perception of users on the informative component of pre-test counseling, in Fortaleza-Ceará. Descriptive-exploratory study, with qualitative approach, carried out with thirteen users who participated of pre-test counseling, in an unit of reference for DSTs. Data collection occurred from March to April, 2007, through semi-structured interviews. Data were organized in categories and the analysis was based on educational/informative component of counseling for DST/HIV/aids, recomended by Ministry of Health/Brazil. It was found that users perceive the importance of this component of pre-test counseling for anti-HIV as preventive strategy, contributing greatly to the auto-perception of risks and vulnerability, and to the decision to submit themselves to the test.