Ring Cavity Erbium-Doped Fiber for Refractive Index Measurements.

In this study, an interrogation system based on an erbium-doped fiber ring cavity for refractive index measurements is presented and experimentally demonstrated. This cavity ring includes a 1 × 3 coupler wherein one of the fiber output ports is used to increase the optical power of the system by means of an FBG used as a reflector. The other two output ports are used as a refractive index sensing head and reference port, respectively. An experimental demonstration of this proposed sensor system for the measurement of a distinct refractive index is presented.

Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study.

Breast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also affected. As an integrative approach, comparative oncology offers an opportunity to learn more about natural cancers in different species. Methods based on Raman spectroscopy have shown significant potential in the study of the human breast through the fingerprinting of biological tissue, which provides valuable information that can be used to identify, characterize and discriminate structures in breast tissue, in both healthy and carcinogenic environments. One of the most important applications of Raman spectroscopy in medical diagnosis is the characterization of microcalcifications, which are highly important diagnostic indicators of breast tissue diseases. Raman spectroscopy has been used to analyze the chemical composition of microcalcifications. These occur in benign and malignant lesions in the human breast, and Raman helps to discriminate microcalcifications as type I and type II according to their composition. This paper demonstrates the recent progress in understanding how this vibrational technique can discriminate through the fingerprint regions of lesions in unstained histology sections from canine mammary glands.

Detection of the Crystallization Process of Paracetamol with a Multi-Mode Optical Fiber in a Reflective Configuration.

A configuration of a refractometer sensor is described with the aim of optically detecting the crystallization process of paracetamol. The developed sensing head is based on a conventional cleaved multi-mode fiber. The fiber tip sensor structure was submitted to contact with the liquid of interest (paracetamol fully dissolved in 40% v/v of ethanol/water) and the crystallization process of paracetamol, induced with continued exposure to air, was monitored in real time.

Antinociceptive and anti-hypernociceptive effects of Se-phenyl thiazolidine-4-carboselenoate in mice.

In this study, the antinociceptive, anti-hypernociceptive and toxic effects of orally administered (R)-Se-phenyl thiazolidine-4-carboselenoate (Se-PTC, 1-50 mg/kg) were evaluated in mice. Se-PTC did not change plasma aspartate (AST) and alanine aminotransferase (ALT) activities or urea and creatinine levels. Furthermore, in an open field test, Se-PTC did not alter the number of crossings and rearing. Se-PTC significantly reduced the amount of writhing when assessed by acetic acid-induced visceral nociception and attenuated the licking time of the injected paw in the early and late phases of a formalin test. In addition, Se-PTC reduced nociception produced by intra-plantar (i.pl.) injection of glutamate, capsaicin, cinnalmaldehyde, bradykinin, phorbol myristate acetate and 8-Bromo-cAMP. Se-PTC caused a significant increase in hot plate and tail-immersion response latencies, but the antinociceptive effect of Se-PTC in the tail immersion was not abolished by pretreatment with the non-selective opioid receptor antagonist, naloxone. Se-PTC (25 mg/kg) significantly inhibited nociceptive behavior induced by intrathecal (i.t.) injection of glutamate, N-methyl-D-aspartate (NMDA) and (±)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD), but failed to affect nociception induced by kainate and α-amino-3-hydroxy-5-mehtyl-4-isoxazolepropionic acid (AMPA). Mechanical hypernociception induced by carrageenan and Complete Freund's Adjuvant was attenuated by Se-PTC administration. These results indicate that Se-PTC produces antinociception in several models of nociception.

Desenvolvimento e avaliação microbiológica do molho condimentado da biomassa de banana verde / Development and evaluation of microbial biomass spicy sauce of green bananas

O Brasil é o segundo maior produtor de banana (Musa spp.) do mundo, onde 60 por cento da sua produção é desperdiçada, desde o campo até a comercialização. Por isso, estudamos uma forma de aproveitar industrialmente a banana no estágio de maturação verde, desenvolvendo um molho condimentado pastoso e pronto para o consumo, a partir da biomassa desta fruta. As bananas, da variedade casca verde, foram adquiridas no mercado do Pirajá, localizado em Juazeiro do Norte – CE e destinadas a processamento, no Laboratório de Frutos e Hortaliças da Faculdade de Tecnologia – CENTEC Cariri, com apoio da Fundação Cearense de Apoio à Pesquisa – FUNCAP. (...) Por seis meses o produto foi submetido a análises microbiológicas, com base na legislação vigente da Agência Nacional d Vigilância Sanitária – ANVISA, na Resolução –m RDC n. 12 de 02 de janeiro de 2001. As análises serviram para avaliarmos as condições higiênico-sanitárias do processamento e armazenamento. Os resultados obtidos mostram que o produto está dentro dos padrões microbiológicos, indicando que as técnicas utilizadas foram eficientes, adequadas e seguiram as Boas Práticas de Fabricação – BPF.