ABSTRACT
The hierarchical control in biogenic minerals, from precise nanomorphology control to subsequent macroscopic assembly, remains a formidable challenge in artificial synthesis. Studies in biomineralization, however, are largely limited to atomic andmolecular scale crystallization, devoting little attention to biomolecular higher-order structures (HOSs) which critically impact long-range assembly of biominerals. Here we demonstrate a biomimetic route and quantitative simulations that explore peptide HOSs on guiding nanocrystal formation and anisotropic assembly into hierarchical structures. It is found that the Pt{100}-specific peptide T7 (Ac-TLTTLTN-CONH2) adopts ST-turn secondary structure, promoting cubic Pt nanocrystal formation at low concentration, and spontaneously transforms into a ß-sheet with increased concentration. The ß-sheet T7-Pt{100} specificity drives cubic Pt nanocrystals to self-assemble into large-area, long-range, [100] linear assemblies. This study provides a robust demonstration for bio/nonbiogenic material specificity, nanoscale synthesis, and long-range self-organization with biomolecular HOSs and opens vast opportunities for multiscale programmable structures.
