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1.
J Physiol Pharmacol ; 66(5): 653-63, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26579571

ABSTRACT

UNLABELLED: Pancreatic cancer and chronic pancreatitis are still significant diagnostic and clinical problems. The clinical impact of preoperative serum carbohydrate antygen 19-9 (CA 19-9) levels have been disscussed. The aim of this study was a comparative analysis of the concentrations in serum of adipocytokines: adiponectin and leptin and CA 19-9 in patients with pancreatic cancer (PC), chronic pancreatitis (CP) and control group (CG). The study was performed in a group of 90 patients. Group 1 consisted of 30 patients with PC, group 2 consisted of 30 patients with CP. There was no coincidence of pancreatic cancer in CP group. Group 3 (CG) consisted of 30 persons and were recruited among patients operated for cholelithiasis. The serum samples were taken from patients and the concentration of adiponectin, leptin, CA 19-9 and CEA were evaluated. The revealed concentrations levels of the adiponectin were significantly higher in the PC serum samples compared to the CP and CG. There was no significant correlation between increased adiponectin concentration and body fat mass in the PC group. The concentration of leptin was significantly lower in CP serum samples compared to PC and CG. The concentration of leptin was similar in the PC and CG. The concentration of leptin was mainly dependent on body fat mass and fat distribution. Additionally, measurement of waist circumference and body composition was recorded using bioelectrical impedance analysis. CONCLUSIONS: significantly higher concentration levels of adiponectin in the PC group, independent of body fat mass, may play a potential role as a new tumor marker in PC and might be useful in the differential diagnosis between PC and CP, but this statement needs further investigation. To our knowledge, this was the first study evaluating not only body mass index but also the content and distribution of body fat in patients with PC and CP.


Subject(s)
Adiponectin/blood , CA-19-9 Antigen/blood , Leptin/blood , Pancreatic Neoplasms/blood , Pancreatitis, Chronic/blood , Adipose Tissue/physiology , Adult , Aged , Body Composition/physiology , Body Mass Index , Case-Control Studies , Diagnosis, Differential , Electric Impedance , Female , Humans , Male , Middle Aged , Pancreatic Neoplasms/diagnosis , Pancreatitis, Chronic/diagnosis , Waist Circumference/physiology
2.
Pediatr Cardiol ; 29(3): 656-8, 2008 May.
Article in English | MEDLINE | ID: mdl-17676367

ABSTRACT

We describe a case of thrombus formation within a right ventricle-to-pulmonary artery conduit (Sano shunt) in a patient with hypoplastic left heart syndrome with resulting acute cyanosis and hypotension requiring emergency balloon angioplasty.


Subject(s)
Anastomosis, Surgical/adverse effects , Cyanosis/etiology , Heart Ventricles/surgery , Hypoplastic Left Heart Syndrome/surgery , Pulmonary Artery/surgery , Thrombosis/etiology , Acute Disease , Angioplasty, Balloon , Female , Humans , Infant , Thrombosis/therapy
4.
Folia Neuropathol ; 39(4): 237-41, 2001.
Article in English | MEDLINE | ID: mdl-11928894

ABSTRACT

Three types of intranuclear inclusions in neurones, oligodendrocytes and astrocytes were quantitatively evaluated by electron microscopy in the autopsy material derived from six cases of subacute sclerosing panencephalitis (SSPE) with different duration of disease. Viral nucleocapsids were found in neurones and oligodendrocytes with the highest incidence (about 38% of nuclei) in two acute cases (adolescent), whereas in two subacute cases only 10% of nuclei of these cells contained nucleocapsids. However, in one acute case (child) and one chronic case, no nucleocapsids were detected at all, despite very intensive study. Two other types of intranuclear inclusions--nuclear bodies (NBs) and granulofilamentous inclusions (GFs) were present in astrocytic nuclei in all cases. Nuclear bodies were found the most frequently (about 66%) in cases of a several-week-long duration, and their incidence decreased with the extended duration of the disease. In the case of a seven-year-long duration, about 31% of nuclei contained NBs. The incidence of certain types of NBs varied also in individual groups of cases, and the same applied to the occurrence of cellular nuclei with different numbers of NBs. Nuclear bodies types IVand V occurred with similar frequency, regardless of the disease duration. The highest incidence of nucleocapsids and NBs was accompanied by the highest (about 25%) frequency of GF in astrocytic nuclei. The incidence of the latter declined with the prolonged duration of the disease, and in the chronic case it was about 16 times lower than in acute cases. In some acute and subacute cases, GF occurred together with NBs. Astrocytic nuclei with both types of inclusions occurred with a similar frequency (about 1.6-1.8%).


Subject(s)
Cell Nucleus/pathology , Subacute Sclerosing Panencephalitis/pathology , Adolescent , Astrocytes/pathology , Brain/pathology , Cell Nucleus/ultrastructure , Child , Humans , Incidence , Inclusion Bodies/pathology , Measles virus/isolation & purification , Neurons/pathology , Nucleocapsid/ultrastructure , Oligodendroglia/pathology , Subacute Sclerosing Panencephalitis/epidemiology , Subacute Sclerosing Panencephalitis/virology
5.
Folia Neuropathol ; 39(3): 193-202, 2001.
Article in English | MEDLINE | ID: mdl-11770130

ABSTRACT

This paper presents ultrastructural changes in neuronal and glial cells with special reference to intranuclear inclusion bodies in subacute sclerosing panencephalitis (SSPE) with different duration (from several weeks to seven years). Brain autopsy at ultrastructural level revealed the nucleocapsids of paramyxovirus in neuronal and oligodendroglial nuclei in 4 of 6 SSPE cases under study. Nucleocapsids of measles virus were present in two cases of disease lasting several weeks and in two cases with disease duration of two years, while abundant nuclear bodies and granulofilamentous inclusions in astrocytic nuclei were found in all cases. Occasionally, both granulofilamentous inclusions and complex nuclear bodies occurred in the same astrocytic nucleus. Only in the case lasting seven years they were not observed. It is likely that there is a structural and morphological relationship between these two types of inclusions present in astrocytic nuclei. Nuclear bodies and granulofilamentous inclusions were common and independent of the presence or absence of virus nucleocapsids. In the case of SSPE with a seven-year duration but without viral nucleocapsids in neuronal and oligodendroglial nuclei, neuronal tangles were observed.


Subject(s)
Neuroglia/ultrastructure , Subacute Sclerosing Panencephalitis/pathology , Adolescent , Adult , Antibodies, Viral/immunology , Astrocytes/ultrastructure , Child , Female , Humans , Male , Measles/immunology , Neurofibrillary Tangles/ultrastructure , Subacute Sclerosing Panencephalitis/immunology
6.
Anesth Analg ; 90(2): 299-305, 2000 Feb.
Article in English | MEDLINE | ID: mdl-10648310

ABSTRACT

UNLABELLED: An IM combination of meperidine, promethazine, and chlorpromazine (DPT) has been given as sedation for pediatric procedures for more than 40 years. We compared this IM combination to oral (PO) ketamine/midazolam in children having cardiac catheterization. A total of 51 children, ages 9 mo to 10 yr, were enrolled and randomized in this double-blinded study. All children received an IM injection at time zero and PO fluid 15 minutes later. We observed acceptance of medication, onset of sedation and sleep, and sedative efficacy. The cardiorespiratory changes were evaluated. Sedation was supplemented with IV propofol as required. Recovery time, parental satisfaction, and patient amnesia were assessed. Ketamine/midazolam given PO was better tolerated (P < 0.0005), had more rapid onset (P < 0.001), and provided superior sedation (P < 0.005). Respiratory rate decreased after IM DPT only. Heart rate and shortening fraction were stable. Oxygen saturation and mean blood pressure decreased minimally in both groups. Supplemental propofol was more frequently required (P < or = 0.02) and in larger doses (P < 0.05) after IM DPT. Parental satisfaction ratings were higher (P < 0.005) and amnesia was more reliably obtained (P = 0.007) with PO ketamine/midazolam. Two patients needed airway support after the PO medication, as did two other patients when PO ketamine/midazolam was supplemented with IV propofol. Although PO ketamine/midazolam provided superior sedation and amnesia compared to IM DPT, this regimen may require the supervision of an anesthesiologist for safe use. IMPLICATIONS: Oral medication can be superior to IM injections for sedating children with congenital heart disease; however, the safety of all medications remains an issue.


Subject(s)
Adjuvants, Anesthesia , Cardiac Catheterization , Chlorpromazine , Hypnotics and Sedatives , Ketamine , Meperidine , Midazolam , Promethazine , Adjuvants, Anesthesia/administration & dosage , Adjuvants, Anesthesia/adverse effects , Administration, Oral , Child , Child, Preschool , Chlorpromazine/administration & dosage , Chlorpromazine/adverse effects , Double-Blind Method , Hemodynamics/drug effects , Humans , Hypnotics and Sedatives/administration & dosage , Hypnotics and Sedatives/adverse effects , Infant , Injections, Intramuscular , Ketamine/administration & dosage , Ketamine/adverse effects , Meperidine/administration & dosage , Meperidine/adverse effects , Midazolam/administration & dosage , Midazolam/adverse effects , Promethazine/administration & dosage , Promethazine/adverse effects
7.
Neurol Neurochir Pol ; 33(4): 797-805, 1999.
Article in Polish | MEDLINE | ID: mdl-10612094

ABSTRACT

A follow-up study was carried out of 16 SSPE patients two years after completion of 6-month treatment with Antineoplaston. The study was based on an inquiry sent to the families of the patients and on control examinations at the clinic. In the period of follow-up 6 patients died, all had the downhill type of disease course and their mean survival was 18 months. Out of the remaining 10 patients 4 are in stationary condition and the remaining ones had minimal worsening. A more detailed clinical analysis showed that half the patients were in contact with and general orientation in the environment, but impairment of motor functions made difficult in most cases self-care and self-dependent functioning. All patients had evident changes in brain MRI. The survival time of the patients has been as yet from 2.5 to 5.5 years (mean 3.9 years). The results of the treatment with Antineoplaston AS2-1 + isoprinosine are comparable with those observed during isoprinosine alone treatment but significantly worse than those after administration of Propionibacterium granulosum with isoprinosine. This suggests that Antineoplaston AS2-1 fails to modify importantly the natural course of SSPE.


Subject(s)
Glutamine/analogs & derivatives , Phenylacetates/therapeutic use , Subacute Sclerosing Panencephalitis/drug therapy , Adjuvants, Immunologic/therapeutic use , Adolescent , Adult , Brain/pathology , Disease Progression , Drug Combinations , Drug Therapy, Combination , Female , Follow-Up Studies , Glutamine/therapeutic use , Humans , Inosine Pranobex/therapeutic use , Magnetic Resonance Imaging , Male , Subacute Sclerosing Panencephalitis/diagnosis , Subacute Sclerosing Panencephalitis/mortality , Survival Rate , Treatment Outcome
8.
Neurol Neurochir Pol ; 33(1): 79-85, 1999.
Article in Polish | MEDLINE | ID: mdl-10399727

ABSTRACT

The purpose of the study was the assessment of humoral response markers in 20 patients with SSPE in phase I, II and III of the disease during immunomodulating treatment. In the CSF IgG levels were determined by nephalometric method, with its share in the total protein level, and with determination of the local IgG synthesis in CNS by Reiber method, 24-hour IgG synthesis by Tourtellotte-Boce method, IgG index by Link-Tibbling method and albumin index. Oligoclonal IgG was determined by isoelectrofocusing. All mathematical tests indicating IgG synthesis in CSF were abnormal in all cases, and also in all cases oligoclonal IgG was found (type 3 of electrophoresis separation pattern). The results point to far reaching changes of the humoral immune response in SSPE persisting also during immunomodulating treatment independently of disease phase and duration. In only 10% of cases abnormal values of the albumin index suggested damage to the blood-brain barrier.


Subject(s)
Antibody Formation/immunology , Immunoglobulin G/cerebrospinal fluid , Immunoglobulin G/immunology , Subacute Sclerosing Panencephalitis/immunology , Adolescent , Adult , Child , Female , Humans , Male , Severity of Illness Index
9.
Neurol Neurochir Pol ; 33(5): 1165-72, 1999.
Article in Polish | MEDLINE | ID: mdl-10672566

ABSTRACT

Slow course case of subacute sclerosing panencephalitis is reported. The onset was at the age of 16 years and death followed after 5 years. He was observed during nine successive hospitalizations and the authors describe the changing clinical symptomatology parallelly with successive EEG records and brain MR imaging evolution. Successive phases of the disease were associated with hyperintense changes in T2-weighted.images, and were situated initially in occipital lobes, and involved later on periventricular areas and finally the whole white matter of both cerebral hemispheres. Subcortical brain atrophy developed parallelly.


Subject(s)
Brain/pathology , Subacute Sclerosing Panencephalitis/diagnosis , Adolescent , Adult , Atrophy/pathology , Chronic Disease , Humans , Magnetic Resonance Imaging , Male
10.
Neurol Neurochir Pol ; 32(5): 1081-9, 1998.
Article in Polish | MEDLINE | ID: mdl-10463223

ABSTRACT

The aim of this study is a clinical and electroencelographic analysis of those SSPE patients who suffered epileptic seizures in course of the disease. The material is based on an analysis of a computed database including 1180 case histories from multiple hospitalizations of 248 SSPE patients (141 males, 107 females) in years 1978-1995. The analysis was made using computer system EPI-INFO 6. The average age of SSPE onset was 12.3 +/- 4.5 (range 4-27.5). 74.2% of patients developed the disease before the age of 15. Epileptic seizures occurred in 43.5% (N = 108) of all SSPE patients in different stages of the disease. In 47 patients (M-21; F-26) they were observed among first SSPE symptoms, in 41 of those the seizures had the form of GTCS. Epileptic seizures were more frequent in patients with SSPE onset before the age of 15 (50.5%) than in patients with later onset (23.4%). More frequent occurrence of epileptic seizures and epileptiform changes in EEG in children under 15 can be associated with specificity of developmental age: immaturity of nervous and endocrine system and decreased convulsant threshold.


Subject(s)
Epilepsy/diagnosis , Adult , Age Factors , Electroencephalography , Female , Humans , Male , Retrospective Studies , Severity of Illness Index
11.
Neurol Neurochir Pol ; 31(3): 475-91, 1997.
Article in Polish | MEDLINE | ID: mdl-9446041

ABSTRACT

Computer-assisted analysis was done of database containing 1180 records of 249 patients with SSPE hospitalized repeatedly at the I Dept. of Neurology using the EPI INFO 6 computer system recommended by the WHO. Boys were slightly prevalent in these cases (58%). The results of the analysis showed a falling incidence of SSPE among children born after 1976 (increased mean age of onset and death with successive years and hospitalization period, but without correlation between the mean age at onset and the birth year, decreased number of patients born after 1978 and absence of new admissions of those born after 1984). The falling incidence of SSPE can be a result of the introduction in 1976 of routine measles vaccination. 80.5% of the patients had measles, and 70.5% had it in the first two years of life (mean age to onset 2.34 +/- 2.32). Only 29 patients (11.6%) had had measles vaccination, and 15 of them (6%) had had measles.


Subject(s)
Subacute Sclerosing Panencephalitis/epidemiology , Adolescent , Adult , Age of Onset , Child , Child, Preschool , Data Interpretation, Statistical , Female , Hospitalization/statistics & numerical data , Humans , Incidence , Male , Mathematical Computing , Patient Admission/statistics & numerical data , Poland/epidemiology , Prevalence , Retrospective Studies , Sex Distribution , Subacute Sclerosing Panencephalitis/rehabilitation
12.
Pol Merkur Lekarski ; 2(10): 254-5, 1997 Apr.
Article in Polish | MEDLINE | ID: mdl-9377658

ABSTRACT

Leukotrienes B4 and C4 have been assayed in CSF of 24 patients with the attacks or slowing-progressing course of multiple sclerosis, and in 23 patients with other noninflammatory diseases. Leukotrienes concentrations have been assayed with RIA technique with the use of commercially available kits manufactured by Amersham. Leukotrienes B4 and C4 levels in CSF of patients with multiple sclerosis have been 91.8 +/- 5.6, and 88.6 +/- 7.5 pg, and have been significantly higher than those in other neurological disorders (p < 0.01). Mean LTB4 and LTC4 levels have been significantly lower in patients with atherosclerotic dementia (69, 12.2 and 63, 02.9 pg/ml) or in patients with headache (72.7 +/- 2.8 and 64.5 +/- 8.2 pg/ml). Higher LTB4 and LTC4 levels in patients with multiple sclerosis is probably due to both increased penetration through blood-brain barrier and their synthesis in blood-brain barrier, and cerebral nervous tissue. Further investigations are necessary to show whether LTB4 and LTC4 levels may indicate a stage of inflammatory process activity and enable to draw any conclusions on efficacy of anti-inflammatory therapy.


Subject(s)
Leukotriene B4/cerebrospinal fluid , Leukotriene C4/cerebrospinal fluid , Multiple Sclerosis/cerebrospinal fluid , Blood-Brain Barrier , Humans , Radioimmunoassay
13.
Neurol Neurochir Pol ; 31(6): 1147-56, 1997.
Article in Polish | MEDLINE | ID: mdl-9591301

ABSTRACT

A tentative treatment with Antineoplaston AS2-1 was carried out in a group of 16 patients with subacute sclerosing panencephalitis (SSPE). Most patients were in phase II of SSPE (after Jabbour) with mean disease duration 6.4 months. Their age ranged from 13 to 28 years. They were given for 6 months 15 capsules of Antineoplaston AS2-1 and 6 tablets of isoprinosine daily. Despite that treatment progression was observed of the disturbances of higher nervous functions, less so of motor functions. The treatment had no effect on MRI results, EEG and antimeasles antibodies levels. No adverse effects were observed.


Subject(s)
Antineoplastic Agents/therapeutic use , Glutamine/analogs & derivatives , Phenylacetates/therapeutic use , Subacute Sclerosing Panencephalitis/drug therapy , Adolescent , Adult , Antiviral Agents/therapeutic use , Drug Combinations , Drug Therapy, Combination , Female , Glutamine/therapeutic use , Humans , Inosine Pranobex/therapeutic use , Male , Time Factors , Treatment Outcome
14.
J Perinatol ; 16(3 Pt 1): 186-90, 1996.
Article in English | MEDLINE | ID: mdl-8817427

ABSTRACT

OBJECTIVE: The objective of this study was to analyze the clinical course and neurodevelopmental outcome of infants with total anomalous pulmonary venous drainage (TAPVD) who were treated with venoarterial extracorporeal life support (ECLS). STUDY DESIGN: The study was done by retrospective national survey of ECLS centers located in the United States and Australia. Sixty-six patients from 28 centers that reported cases from 1976 to October 1992 to the Extracorporeal Life Support Organization registry were included in the study. Data regarding type of TAPVD, whether the diagnosis was known or suspected before the initiation of ECLS, method of diagnosis, timing of repair if done, outcome, and follow-up were collected. RESULTS: Fifty-six of the patients were placed on ECLS at ages < 14 days (neonatal) and 10 patients underwent ECLS at ages > or = 14 days (pediatric). TAPVD was known or suspected before the initiation of ECLS in 35 (53%) of 66 and was most commonly diagnosed by color-flow Doppler echocardiography if initially missed. Surgical repair was not attempted in four of the 66 patients, leaving a total of 62 patients for comparison. The overall operative survival for both neonatal and pediatric patients was 24 (39%) of 62. The survival rate for neonates who underwent repair before ECLS was seven (54%) of 13, for those who underwent repair after ECLS it was six (60%) of 10, and for those who underwent repair during ECLS survival was seven (24%) of 29. Neonatal survival (20/52, 38%) was statistically more likely (p = 0.05) if the repair was done before or after ECLS rather than during ECLS, with each group compared separately. Follow-up data were available on 13 of 20 neonates and three of four pediatric patients. Bayley Scales of Infant Development scores were normal in only six (54%) of 11 survivors who returned for testing. CONCLUSIONS: The diagnosis of TAPVD was often known before the initiation of ECLS. Neonates were more likely to survive if the repair could be done before or after ECLS rather than during ECLS. The lower survival of infants who underwent repair during ECLS reflects the degree of illness in many of these infants who were placed on ECLS on an emergency basis because their condition was too unstable to permit detailed cardiac evaluation. The survival rate of infants with TAPVD requiring ECLS is poor, with approximately one half of the survivors having mental and motor deficiencies; however, these infants represent a subset of patients with TAPVD who probably would have died without ECLS. We recommend that infants who are not starting to wean from ECLS at 7 days undergo reevaluation with color-flow Doppler echocardiography with consideration for cardiac catheterization if the diagnosis is in doubt. We also recommend that before infants with known TAPVD are placed on ECLS parents should be informed that survival with the use of ECLS is no different from survival with operation alone and that many of the survivors are impaired. Each active ECLS center should periodically review its accuracy in making this definitive diagnosis.


Subject(s)
Extracorporeal Membrane Oxygenation , Heart Defects, Congenital/therapy , Pulmonary Veins/abnormalities , Extracorporeal Membrane Oxygenation/methods , Female , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/mortality , Humans , Infant, Newborn , Male , Pulmonary Veins/surgery , Registries , Retrospective Studies , Risk Factors , Survival Rate , Treatment Outcome
15.
ASAIO J ; 42(3): 142-5, 1996.
Article in English | MEDLINE | ID: mdl-8725678

ABSTRACT

The objective of this study was to determine the efficacy of two-dimensional and contrast echocardiograms to identify venous cannula position. Sequential sampling of 20 infants was evaluated by contrast echocardiography after meeting institutional criteria for extracorporeal life support. Each infant was placed on venovenous extracorporeal life support using a double-lumen cannula. After surgical placement was thought to be satisfactory, optimal two-dimensional images of the cannula were obtained via a subxiphoid or apical view and 2 ml agitated normal saline were injected rapidly into the nearest infusion port. Patient demographics and mixed venous saturations were noted. Distance of the venovenous cannula to tricuspid valve and distance of the venovenous cannula from the intra-atrial septum was recorded. Echocardiograms were available for review on 18 of the 20 patients. Position of the venovenous cannula in relationship to the tricuspid valve was as follows: < 5 mm (8); 5-10 mm (5); > 10 mm (5). Mixed venous saturations decreased, which indicated less recirculation when the orientation of the tip of the cannula was toward the lateral wall in those who required repositioning. The authors conclude that two-dimensional and contrast echocardiography aid in the positioning of the venovenous cannula. Satisfactory position is approximately 5 mm from the tricuspid valve, with orientation toward the lateral wall of the right atrium.


Subject(s)
Catheterization, Central Venous , Echocardiography/standards , Extracorporeal Circulation , Female , Humans , Infant, Newborn , Life Support Systems/standards , Male
16.
South Med J ; 89(4): 420-1, 1996 Apr.
Article in English | MEDLINE | ID: mdl-8614886

ABSTRACT

We describe the clinical evaluation and surgical treatment of a 7-year-old child who had severe coronary artery obstructions that occurred as a sequela of previously diagnosed Kawasaki disease.


Subject(s)
Coronary Artery Bypass/methods , Coronary Disease/etiology , Coronary Disease/surgery , Mucocutaneous Lymph Node Syndrome/complications , Child , Constriction, Pathologic , Coronary Angiography , Coronary Disease/diagnostic imaging , Electrocardiography , Humans , Male , Treatment Outcome
18.
J Ky Med Assoc ; 93(4): 142-7, 1995 Apr.
Article in English | MEDLINE | ID: mdl-7751805

ABSTRACT

This article reviews the development and progress of an innovative, comprehensive school health project in the Jefferson County school district known as the Health Promotion Schools of Excellence (HPSE). This project features unique working relationships between public and private entities seeking a common goal: "A Healthier Community." The goals and development of HPSE have been formulated to coincide with the emerging directives of the Kentucky Education Reform Act (KERA) as well as the growing pressures to control health care costs through effective preventive measures. The results of testing following the first and second years of the project show an encouraging trend of improved physical fitness levels for all students (grades K-12) and improving levels of health knowledge and attitudes in elementary level children (grades 4-8) as well as school faculty and staff. These initial results, although encouraging, will only be meaningful if they translate over time into a healthier, more responsible cohort of adolescents and young adults when compared to their peers not involved in the project. The project, while only in its third year of development, has already been recognized at regional and national levels as a successful model of a comprehensive school health program. As the project continues and grows, the authors anticipate developing one of the nation's largest and most comprehensive longitudinal data bases of childhood and adolescent health information.


Subject(s)
Health Promotion , School Health Services/organization & administration , Adolescent , Child , Cohort Studies , Health Behavior , Health Knowledge, Attitudes, Practice , Health Promotion/economics , Health Promotion/methods , Humans , Kentucky , Program Development , Risk Factors , School Health Services/economics
19.
Clin Infect Dis ; 19(1): 166-8, 1994 Jul.
Article in English | MEDLINE | ID: mdl-7948524

ABSTRACT

To our knowledge, we report the first case of group B streptococcal endocarditis that occurred in an infant after the neonatal period. A large, friable vegetation had destroyed the tricuspid valve and resulted in pulmonary emboli. Surgical resection of the valve was needed to achieve clinical cure of the patient. A review of the English-language literature on older patients with group B streptococcal endocarditis revealed a mortality rate of 60% among patients treated with antimicrobial drugs alone and a mortality rate of 29% among those whose treatment included both surgery and therapy with antimicrobial drugs. Surgical debridement of the valve may be necessary for children with large vegetations, which tend to embolize and thus contribute to the morbidity and mortality associated with group B streptococcal endocarditis.


Subject(s)
Endocarditis, Bacterial/surgery , Streptococcus agalactiae/isolation & purification , Tricuspid Valve/microbiology , Echocardiography , Endocarditis, Bacterial/diagnostic imaging , Female , Humans , Infant , Streptococcal Infections/surgery
20.
Pol Tyg Lek ; 49(20-22): 487-8, 1994.
Article in Polish | MEDLINE | ID: mdl-7651922

ABSTRACT

In the cerebrospinal fluid of two groups of patients with subacute sclerosing panencephalitis (SSPE), the determinations of LTB4 and LTC4 leukotriene concentrations were performed by radioimmunoassay (RIA). In the first group of 10 patients with chronic SSPE (from 2 to 11 years), the LTB4 and LTC4 levels were 94.8 +/- 17.0 and 97.4 +/- 16.8 pg/ml respectively, and were significantly higher than those in six patients with discopathy, epilepsy and headache (p < 0.01). In the second group of 10 patients with beginning SSPE (disease duration from 1 to 11 months) LTB4 level was lower (was not different from that in the control group), while LTC4 concentration was 97.6 +/- 10.8 pg/ml and again was significantly raised. Higher LTB4 and LTC4 levels in the cerebrospinal fluid of patients with SSPE indicate that these compounds participate in chronic inflammatory reaction around cerebral veins.


Subject(s)
Leukotriene B4/cerebrospinal fluid , Leukotriene C4/cerebrospinal fluid , Subacute Sclerosing Panencephalitis/cerebrospinal fluid , Adolescent , Adult , Child , Chronic Disease , Female , Humans , Male , Radioimmunoassay
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