ABSTRACT
An exploratory case-control study of the role of diet in the etiology of breast cancer was conducted in Buenos Aires, Argentina, where the mortality rate for this disease is high and the consumption of meat, mainly beef, is unusually elevated (76.2 kilograms per head were reported for 1987). One hundred and ninety-six women with breast cancer admitted to the Institute of Oncology "Angel H. Roffo" and 205 controls were interviewed to obtain information on demographic, socio-economic and reproductive variables, on frequency of consumption of 40 food items, and on methods of cooking. Special emphasis was given to different kinds of meat. After controlling for other risk factors for breast cancer the major dietary associations observed were a statistically insignificant trend of increasing risk with amount of beef consumed, an increase in risk in women who ate more than 3 eggs per week, and an increase in risk in women who ate a variety of fried foods.
Subject(s)
Breast Neoplasms/etiology , Diet , Meat , Adult , Aged , Argentina , Body Weight , Case-Control Studies , Female , Humans , Middle Aged , Odds Ratio , Regression Analysis , Risk FactorsABSTRACT
Se estudiaron 40 floricultores ocupacionalmente expuestos a plaguicidas, integrantes de una población de 154 individuos de una colonia agrícola. Veinte de ellos tenían síntomas sospechosos de ser producidos por exposición prolongada a plaguicidas y 20 eran asintomáticos y fueron considerados como controles. En cada individuo se determinó recuento y fórmula sanguínea, hemoglobina, hematocrito, GOT, GPT y colinesterasa plasmática. En la evaluación de los datos bioquímicos resaltó la incidencia de leucopenias (valores <- 5.000 glóbulos blancos/mm), en el 42% de la población estudiada. Esta disminución de glóbulos blancos no apareció correlacionada con la presencia de sintomatología. El resto de los análisis realizados no mostró desviaciones de los valores normales
Subject(s)
Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Environmental Exposure , Leukopenia/chemically induced , Pesticides/adverse effects , Argentina , Cholinesterases/bloodABSTRACT
Se estudiaron 40 floricultores ocupacionalmente expuestos a plaguicidas, integrantes de una población de 154 individuos de una colonia agrícola. Veinte de ellos tenían síntomas sospechosos de ser producidos por exposición prolongada a plaguicidas y 20 eran asintomáticos y fueron considerados como controles. En cada individuo se determinó recuento y fórmula sanguínea, hemoglobina, hematocrito, GOT, GPT y colinesterasa plasmática. En la evaluación de los datos bioquímicos resaltó la incidencia de leucopenias (valores <- 5.000 glóbulos blancos/mm), en el 42% de la población estudiada. Esta disminución de glóbulos blancos no apareció correlacionada con la presencia de sintomatología. El resto de los análisis realizados no mostró desviaciones de los valores normales (AU)
Subject(s)
Child , Adolescent , Adult , Middle Aged , Aged , Humans , Male , Female , Pesticides/adverse effects , Leukopenia/chemically induced , Environmental Exposure , Cholinesterases/blood , ArgentinaABSTRACT
Sister-chromatid exchanges (SCE) and chromosomal aberrations were studied in a population of floriculturists occupationally exposed to organophosphorus, carbamate and organochlorine pesticides. Blood samples from 36 individuals from a community of 154 persons of asiatic origin were obtained. Among the group sampled, 21 individuals exhibited at least one symptom of chronic intoxication. SCE analysis was performed in 14 symptomatic and 13 asymptomatic persons. The asymptomatic group showed a SCE frequency of 5.47 +/- 1.03 and the symptomatic group a frequency of 6.45 +/- 1.19. Comparison between both groups with the Mann-Whitney 'U' test revealed a significant difference (p 0.0409). Case-control analysis of 9 pairs matched by sex and age also showed significant differences between both groups (p 0.0104). In contrast, the frequencies of chromosomal aberrations were not correlated with intoxication symptomatology, though a significant increment of exchange-type aberrations in relation to a group of non floriculturists was observed in the population studied.