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Rev Esp Fisiol ; 32(4): 275-9, 1976 Dec.
Article in English | MEDLINE | ID: mdl-1005886

ABSTRACT

Thiotixene and thioridazine antipsychotic drugs produce a stimulation of mitochondrial respiration in state 3 and state 4 resulting in a complete respiratory control loss, only accompanied by slight alterations of oxidative phosphorylation. This effect may be of biological significance in the action mechanism of the drugs.


Subject(s)
Mitochondria, Liver/drug effects , Thioridazine/pharmacology , Thiothixene/pharmacology , Animals , Mitochondria, Liver/physiology , Oxidative Phosphorylation , Rats , Stimulation, Chemical
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