ABSTRACT
A set of 620 patients was examined. Out of them, 245 suffered from lung carcinoma of different type and stage, 28 suffered from other malignant tumors, 37 were affected with benign tumors, and 166 were suffering from a nonmalignant respiratory disease (tuberculosis, nonspecific pneumonia, chronic bronchitis, abscesses, cysts, asthma, lung fibrosis, bronchiectasis and sarcoidosis). In addition to these patients, 144 blood donors were examined who represented the control group of healthy individuals. In a blind test another set of 266 persons was examined. By completing the values of selected markers (orosomucoid, prealbumin, glycoprotein electrophoresis, erythrocyte sedimentation, age of the individual, and the number of smoked cigarettes) into the discrimination rule and by calculating the discrimination function, a sensitivity of 80.6% and a specificity of 75.6% were obtained. A comparative cytological examination of the same set revealed lower sensitivity (61.0%) but higher specificity (98.0%). These values were verified in a blind test, as the patients were admitted to the hospital. Sensitivity in lung cancer was found to be 83.9%; in nonmalignant diseases the respective value was 77.1%. This approach can be applied to individuals suspect of cancer, in secondary prevention and in individuals with a high risk of lung cancer.
Subject(s)
Lung Diseases/diagnosis , Lung Neoplasms/diagnosis , Statistics as Topic , Adult , Age Factors , Aged , Biomarkers, Tumor/blood , Diagnosis, Differential , Diagnostic Errors , Humans , Lung Diseases/blood , Lung Neoplasms/blood , Lung Neoplasms/prevention & control , Middle Aged , Predictive Value of Tests , Risk Factors , SmokingSubject(s)
Esterases/metabolism , Orosomucoid/blood , Schizophrenia/blood , alpha 1-Antitrypsin/metabolism , Adult , Humans , Middle AgedABSTRACT
Serum esterase activity was estimated in 148 patients with bronchogenic carcinoma and in 19 patients with pulmonary tuberculosis before operation, 1 week and 3 weeks after operation. We failed to prove significant differences between the patients with malignant and nonmalignant lung diseases. We failed also to prove significant differences between the mean esterase activity findings regarding to the extent of surgery. They were identical even of the performed thoracotomy was radical, palliative or explorative. The course of changes in esterase activity findings is quite individual. From the esterase activity we cannot conclude, if the tumor tissue was completely removed or not.
Subject(s)
Carcinoma, Bronchogenic/enzymology , Esterases/blood , Lung Neoplasms/enzymology , Carcinoma, Bronchogenic/surgery , Humans , Lung Neoplasms/surgery , Polysorbates , Tuberculosis, Pulmonary/enzymology , Tuberculosis, Pulmonary/surgerySubject(s)
Immunologic Techniques , Leukocyte Adherence Inhibition Test , Neoplasms/diagnosis , Female , Humans , Male , Neoplasms/immunologyABSTRACT
The data obtained with routine biochemical, immunological and haematological tests in healthy blood donors and in patients with lung cancer were subjected to discrimination analysis with the aim to select the minimum possible combination of methods with the highest probability of distinguishing between the two groups. Transformation of lymphocytes (TR.LY) after PHA stimulation, formation of E-rosettes (E-ROS), and blood glycoproteins (GP) were shown to permit the most complete differentiation between the group of patients and the blood donors. On the basis of the above-mentioned tests the discrimination rule could be defined: IF 52,73249 - 0.45913 X E-ROS - 0.40752 X TR.LY + 0.02790 X GP greater than or equal to 0, then the investigated person is classified as a cancer patient while at values less than 0 the person is classified as a healthy individual.
Subject(s)
Lung Neoplasms/diagnosis , Statistics as Topic , Computers , Glycoproteins/blood , Humans , Lung Neoplasms/immunology , Lung Neoplasms/metabolism , Lymphocyte Activation , Phytohemagglutinins/pharmacology , Rosette FormationABSTRACT
Data obtained by biochemical and immunological tests in a group of healthy blood donors and a group of patients with lung cancer were subjected to discrimination analysis in order to find the minimum possible combination of methods which permit reliable differentiation of the two groups., It was revealed that the lymphocyte transformation after stimulation with PHA, the formation of E rosettes and the plasma level of glycoproteins permit complete differentiation between the group of patients and healthy controls. Based on the above three tests discrimination rules can be defined. If 52.73249--0.45913.ROS--0.40752. TRLY + 0.02790 GP greater than or equal to 0, the investigated subject can be included in the group of patients, when the values are smaller, the subject is healthy.
