[Effect of lithium preparations on cardiac arrhythmias due to strophanthin in waking rats]. / Vliianie preparatov litiia na serdechnye aritmii, vyzvannye strofantinom, u bodrstvuiushchikh krys.

It was shown in experiments on conscious rats that intravenous injection of strophanthine in toxic doses provokes heart arrhythmias and death of the animals. Lithium drugs (lithium chloride and lithium hydroxybutyrate) injected during arrhythmias led to a short-lived effect of heart rhythm normalization. Lithium hydroxybutyrate was more effective if administered shortly after strophanthine injection, reducing the latter's cardiotoxic effect and preventing the death of the majority of the animals.

[Role of the sympathetic nervous system during reparative regeneration and compensation of heart function in experimental myocardial infarct]. / Rol' simpaticheskoi nervnoi sistemy v protsessakh reparativnoi regeneratsii i kompensatsii funktsii serdtsa pri éksperimental'nom infarkte miokarda.

Experiments on chemically sympathectomized rats have revealed a double effect of the sympathetic nervous system on compensation and adaptation of heart function and reparative regeneration in myocardial infarction. It has been established that if the sympathetic influences are excluded, the elements of the connective tissue are activated, which leads to myocardial infarction healing at a shorter period of time. At the same time it has been demonstrated that sympathectomy inhibits the development of the compensatory reactions and limits adaptation possibilities of the heart.

[New informative index of the functional status of polymorphonuclear neutrophils]. / O novom informativnom pokazatele funktsional'nogo sostoianiia segmentoiadernykh neitrofilov.

A new test was applied to study the function of polymorphonuclear neutrophils according to their ability to form oreols in a hypertonic medium. During inhibition of neutrophil function in vivo (desympathetization, tumor growth), oreol formation increased. Stimulation of neutrophils in vitro by adding noradrenaline to the incubation medium led to a decrease in their oreol-forming ability. The data obtained enabled the authors to offer the test for detecting the functional activity of polynuclear cells.

[Morpho-functional changes in the heart of sympathectomized animals during acute myocardial ischemia]. / O morfofunktsional'nykh izmeneniiakh v serdtse desimpatizirovannogo zhivotnogo pri ostroi ishemii miokarda.

Experiments on 142 Wistar male rats were made to study the effect of chemical desympathization on functional and structural changes in the heart during acute myocardial ischemia produced by ligation of the anterior descending branch of the left coronary artery. In the desympathized rats with acute myocardial ischemia, arrhythmias occurred in a less number of cases and were less severe. One day after the artery occlusion the decrease in myocardial contractility was less considerable than in the control animals. More rapid localization of the ischemic focus was found to occur in the desympathized myocardium. The pattern of changes in lipid metabolism in the desympathized and in normally innervated heart was different: in the desympathized heart accumulation of neutral fat was observed while in the normal one acid lipids. It is concluded that different pattern of functional and structural changes in the myocardium of the normal and desympathized animal is determined by the status of the heart sympathetic nervous system, namely by a decrease or elimination of the pathogenic action on the myocardium of noradrenaline which is released in high concentrations because of sharp stimulation of the sympathoadrenal system.

[Effect of lithium preparations on the toxic effects of adrenaline]. / Vliianie preparatov litiia na toksicheskie éffekty noradrenalina.

Experiments on rats have shown that intravenous injection of adrenaline in a dose of 0.3-0.4 mg/kg causes cardiac arrhythmia. In this case the primary arrhythmia developing immediately after adrenaline injection is followed by the recovery of sinusal rhythm which was replaced by the secondary arrhythmia. Apart from arrhythmias, there developed pulmonary edema. The animals died 2--3 minutes after adrenaline injections. Lithium chloride and lithium hydroxybutyrate removed the secondary arrhythmia and pulmonary edema. Lithium hydroxybutyrate has proved to be more effective.

[Reaction of the heart of chemically desympathized animals to functional loading]. / Reaktsiia serdtsa khimicheski desimpatizirovannogo zhivotnogo na funktsional'nye nagruzki.

Effect of chemical desympathization on heart contractile function was studied in experiments on Wistar rats (22 experimental and 20 control animals) under conditions of exposure to functional loads. These loads were realized by heart stimulation at an increasing rate and by a short-term aorta occlusion (as maximum load). The data obtained indicate the depression of contractile function of the desympathized heart exposed to stimulation and maintenance of its contractility under occlusion. It is inferred that the adaptation resources of the desympathized heart are reduced under conditions that require mobilization of the mechanism [interval -- force] and are preserved during heart hyperfunction in isometric regime.