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1.
Rocz Panstw Zakl Hig ; 45(1-2): 131-7, 1994.
Article in Polish | MEDLINE | ID: mdl-7878337

ABSTRACT

Cation exchange resins were applied to eliminate radiocesium from rats. The resins were administered intragastrically immediately after contamination 137CsCl and with delay of 1, 2, 6 and 12 hours. Inorganic cation resins applied with a few hours delay after contamination were shown to be highly effective.


Subject(s)
Cation Exchange Resins/administration & dosage , Cesium Radioisotopes/pharmacokinetics , Animals , Decontamination/methods , Feces/chemistry , Male , Rats , Rats, Wistar
2.
Rocz Panstw Zakl Hig ; 43(2): 163-7, 1992.
Article in Polish | MEDLINE | ID: mdl-1470863

ABSTRACT

It was shown that diuretics: diuramid and furosemide enhance elimination of radiocesium by organic ion exchanger Amberlite 252 from the rat. Administration of Amberline 252 together with hydrocortisone is more effective in radiocesium elimination than administration Amberline only. Using mentioned-above agents 2 hours after administration of radiocesium and even 9 days after contamination cause significant reduction of radioisotope retention period in rat organism.


Subject(s)
Acetazolamide/administration & dosage , Cesium Radioisotopes/pharmacokinetics , Furosemide/administration & dosage , Hydrocortisone/administration & dosage , Ion Exchange Resins/administration & dosage , Resins, Synthetic/administration & dosage , Animals , Drug Synergism , Male , Rats , Rats, Wistar
3.
Rocz Panstw Zakl Hig ; 42(1): 51-4, 1991.
Article in Polish | MEDLINE | ID: mdl-1788512

ABSTRACT

The transfer of radiocesium from blood to the lumen of individual sections of the gastro-intestinal tract was quantitatively determined. The water suspension of ion exchange resin was injected to the lumen of the individual sections of the gastro-intestinal tract. The sections were ligated. The highest amount of radiocesium absorbed to the resin in the lumen of gastro-intestinal tract was observed 3 hrs after intravenous administration 137CsCl and reached 17.7% of the administered dose. It was shown that the small intestine and the ileum play the biggest role in absorption and excretion of the radiocesium. The role of the duodenum, the large intestine and the stomach is much smaller in this process.


Subject(s)
Cesium Radioisotopes/metabolism , Intestines/radiation effects , Models, Biological , Stomach/radiation effects , Animals , Cesium Radioisotopes/administration & dosage , Cesium Radioisotopes/blood , Femoral Vein , Gastric Mucosa/metabolism , Injections, Intravenous , Intestinal Absorption/physiology , Intestinal Absorption/radiation effects , Intestinal Mucosa/metabolism , Male , Metabolic Clearance Rate/physiology , Radioactivity , Rats , Rats, Inbred Strains , Time Factors
4.
Rocz Panstw Zakl Hig ; 42(3): 291-6, 1991.
Article in Polish | MEDLINE | ID: mdl-1841443

ABSTRACT

The specific activity of radiocesium in the liver, brain, heart and thigh muscle was measured during 14 days after a single intragastric administration of 137CsCl. The highest concentrations of radiocesium in the heart and liver were obtained quickly - 3 hours after administration. Cupric ferrocyanide, an ion exchanger displaying strong affinity to the cesium ion, was used to reduce the concentration of this radionuclide in the above-mentioned organs, there was a substantial reduction of cesium retention in the heart and liver indicating that the bonds between the cesium ion and proteins in the heart and liver are weak. Concentrations of radiocesium in the high muscle and brain were highest after 2 days, the application of ion exchanger led to the higher retention of the investigated radionuclide, explainable by the presence of stronger bonds between cesium and proteins in the thigh muscle and brain.


Subject(s)
Cesium Radioisotopes/analysis , Liver/chemistry , Myocardium/chemistry , Animals , Brain Chemistry , Male , Muscles/chemistry , Rats , Rats, Wistar
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