ABSTRACT
Mucocutaneous leishmaniasis of the nose: a case report. Leishmaniasis is a parasitic infection that is rarely seen in Belgium. The majority of new diagnoses are seen in patients living in or visiting endemic regions, which are mostly developing countries. Here we describe the case of a 60-year-old male patient who was referred to an ENT specialist because of an erythematous swelling of the left side of the nose tip, which had persisted for 3 months. Biopsies showed the presence of leishmaniasis. This case report alerts ENT physicians that leishmaniasis is part of the differential diagnosis in patients who present with an uncommon persistent lesion in the head and neck region and who have travelled to endemic regions or are immunodeficient.
Subject(s)
Leishmaniasis, Mucocutaneous , Nose Diseases/parasitology , Humans , Leishmaniasis, Mucocutaneous/diagnosis , Leishmaniasis, Mucocutaneous/drug therapy , Male , Middle Aged , Nose Diseases/diagnosis , Nose Diseases/drug therapySubject(s)
Leishmania/isolation & purification , Leishmaniasis, Cutaneous/diagnosis , Skin Ulcer/diagnosis , Skin/pathology , Travel , Adult , Animals , Diagnosis, Differential , French Guiana/ethnology , Humans , Leishmaniasis, Cutaneous/complications , Leishmaniasis, Cutaneous/parasitology , Male , Netherlands/epidemiology , Skin/parasitology , Skin Ulcer/ethnology , South America/ethnologyABSTRACT
Persons with multiple syphilis reinfections may play an important role in syphilis transmission. We analysed all syphilis tests carried out for people attending the HIV/sexually transmitted infection (STI) clinic at the Institute of Tropical Medicine, Antwerp, Belgium, from 1992 to 2012 to evaluate the extent to which syphilis reinfections were contributing to the syphilis epidemic in Antwerp. We then characterised the features of the syphilis infections in individuals with five or more episodes of syphilis. A total of 729 syphilis episodes were diagnosed in 454 persons. The majority of syphilis episodes occurred in people who had more than one episode of syphilis (445/729; 61%). A total of 10 individuals had five or more episodes of syphilis diagnosed over this period. All were men who have sex with men, HIV positive and on antiretroviral therapy. They had a total of 52 episodes of syphilis diagnosed and treated. In 38/42 of the episodes of repeat syphilis in these 10 individuals, they presented without any signs or symptoms of syphilis. Given that the majority of cases of incident syphilis in our clinic were persons with reinfections and that they frequently presented without signs of symptoms of syphilis, there is a strong case for frequent and repeated screening in all persons with a diagnosis of syphilis.
Subject(s)
Mass Screening/methods , Syphilis Serodiagnosis/standards , Syphilis/diagnosis , Syphilis/epidemiology , Treponema pallidum/isolation & purification , Belgium/epidemiology , HIV Infections/complications , HIV Infections/diagnosis , HIV Infections/epidemiology , HIV Infections/transmission , Homosexuality, Male , Humans , Male , Middle Aged , RecurrenceABSTRACT
We report a case of an HIV seropositive female patient treated with a protease inhibitor-containing regimen who developed recurrent severe life-threathening episodes of haematemesis over time, caused by ruptured oesophageal varices as a consequence of a portal vein thrombosis. Coagulation tests revealed a protein S deficiency, an elevated homocysteinemia and a constitutional elevated plasma factor VIII coagulant activity. These coagulopathies and the HIV infection are independent risk factors for developing venous thromboembolic events. The protease inhibitor treatment may have played a role in increasing the thromboembolic risk. The recurrent bleedings only stopped after invasive surgery. The invasive splenorenal shunt operation was in this case a life-saving procedure.
Subject(s)
Antiretroviral Therapy, Highly Active/adverse effects , HIV Infections/drug therapy , Portal Vein , Protease Inhibitors/adverse effects , Venous Thrombosis/etiology , Adult , Antiretroviral Therapy, Highly Active/methods , Esophageal and Gastric Varices/diagnosis , Esophageal and Gastric Varices/etiology , Female , Follow-Up Studies , HIV Infections/complications , HIV Infections/diagnosis , HIV Seropositivity , Hematemesis/diagnosis , Hematemesis/etiology , Humans , Portography/methods , Protease Inhibitors/therapeutic use , Recurrence , Risk Assessment , Severity of Illness Index , Venous Thrombosis/physiopathology , Venous Thrombosis/surgeryABSTRACT
Amoebic liver abscesses are by far the most common extra-intestinal manifestation of invasive amoebiasis. The classical clinical picture consists of fever, right upper quadrant pain and hepatomegaly. Ultrasound and serology make an early diagnosis possible. Amoebic liver abscesses usually appear singly and are normally situated in the right lobe of the liver. This case report refers to a white Belgian woman, living in an endemic area for amoebiasis, presenting with 25 amoebic liver abscesses, who did not improve clinically despite appropriate anti-amoebic therapy, is described. Only percutaneous drainage of the larger abscesses led to clinical recovery. Amoebic abscess aspiration and evacuation under ultrasonographic guidance is of limited risk, but in experienced hands may enhance clinical recovery, particularly in patients with large abscesses not responding to conservative medical treatment. Aspiration of large abscesses (> 5 cm) is rarely necessary but should be considered if there is no clinical improvement after 3 days of nitroimidazole treatment with amoebicides.
