1.
Chem Commun (Camb)
; 48(70): 8760-2, 2012 Sep 11.
Article
in English
| MEDLINE
| ID: mdl-22836516
ABSTRACT
Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.