Modern universal standardised trends in worker and public exposure monitoring and control in 21st century by Sohrabi URPS-based hypothesis.

The Universal Radiation Protection System (URPS) was recently hypothesised by Sohrabi in order to address the many deficiencies of current radiation protection system. The ICRP system is currently practiced worldwide based on the linear no-threshold (LNT) model with no supporting health risk data at low effective doses. The ICRP only considers worker occupational doses and sets dose limits only on one portion of doses a worker or public receives. The URPS hypothesis equals human heath-effect risks per unit dose either from natural or man-made sources; formulates dose limits on all integrated doses an individual receives; considers worker also a member of public; conserves 'cause-effect principle' for epidemiology risk estimation; introduces dose fractionation concept in radiation protection; introduces the 'URPS Model' for bridging LNT, hormesis and threshold models; recommends establishing 'National Patient Dose Registering System'; and defines modified/new exposure terms and definitions commensurate with URPS hypothesis, as advanced since 2014.

Breakthrough on radon individual monitoring and protecting miners by novel dual-function monitor on respirator.

Breakthrough is made on inventing, producing and applying novel dual-function passive individual radon monitor in canister on respirators for radon inhalation monitoring and protecting individuals in particular miners. The rationale in this invention is having individual monitors for determining actual naturally inhaled radon by individuals and protection against particulates in one device. The monitor comprises two passive polycarbonate track detectors (PCTD); one near canister orifice (PCTD/bare), and one under activated carbon fabric (PCTD/ACF) to detect alphas of radon adsorbed on ACF carbon active sites. The PCTD/ACF detects radon with 12.7 times more sensitivity than PCTD/bare; called "Forced Amplification Factor (FAF)". Monitors were successfully operated and calibrated in laboratory radon chamber using low suction rate pump resembling human natural inhalation. The performance of monitor showed high promises for radon individual monitoring and protection. This novel development also opens new horizons for fundamental and practical scientific research to further upgrade the monitor.

Investigating the safety and efficacy of nerve stimulation for management of groin pain after surgical herniorrhaphy: a systematic review and meta-analysis.

PURPOSE: Chronic post-operative inguinal pain (CPIP) following inguinal hernia repair has been a major sequela affecting 4000-48000 patients annually. Optimal management of CPIP has been a challenge, and pharmacological management particularly with opioids has shown unsatisfactory results. The main objective of this systematic review is to investigate the safety and efficacy of neuromodulation as an alternative intervention for the management of post-operative inguinal pain. METHODS: A literature search was conducted by three reviewers to identify all relevant studies on the use of neuromodulatory interventions for treating post-operative inguinal pain. Data on study characteristics, neuromodulatory modalities, and patient's clinical data such as pre/post-interventional pain scores and analgesic requirements were extracted and reported. RESULTS: A total of 389 patients with 357 (95.9%) males and 15 (4.1%) females were evaluated. The mean age of study participants was 47.9 ± 10.4 years. There were 187 (48.1%) and 202 (51.9%) patients allocated to the control and trial groups, respectively. The most common neuromodulation modality was TENS (4, 36.4%), followed by SCS (3, 27.3%), PNS (3, 27.3%), and acupuncture-assisted (2, 18.2%). The overall mean follow-up duration of the entire cohort was 3.8 months. The mean difference between pre-operative and post-operative VAS scores in the trial groups was 4.65 (95% Confidence Interval [CI], 2.97, 6.33), which was statistically significant (P value < 0.05). Patient-reported outcome measures showed significant responsiveness toward their treatments. CONCLUSION: Nerve stimulation, in its many forms, is a safe and feasible option for the management of post-operative inguinal pain.

The effect of motivational strategy on voluntary plasma donation, a field trial.

BACKGROUND: Plasma protein therapies (PPTs) are a group of medicines extracted from human plasma through fractionation. The manufacture of adequate amounts of PPTs requires a large volume of human plasma. WHO emphasized that whole blood and blood component donations should be voluntary and non-remunerated. So, motivating people to donate plasma is crucial. In this study, we evaluated the impact of social media on motivating blood donors to donate plasma without any compensation and the moderating effects of blood donation history on plasma donation. METHODS AND MATERIALS: we allocated blood donors (n = 501) to intervention and control groups randomly. Participants in the intervention group got educational and motivational messages through a WhatsApp channel. Then, we followed up all participants for six months and registered the information of the plasma donation during this period. RESULT: In the intervention group, 6.8% had returned to donate plasma, while this was 2% in the control group (p = 0.016, OR:3.59, 95%CI:1.3-9.89). Among regular blood donors in the intervention group, 17.86% had returned to donate plasma but, no regular donor returned to donate plasma in the control group (p = 0.055). In addition, 10.8% of donors who had academic education in the intervention group returned to donate plasma, although this was 2.54% in the control group (P = 0.0485). CONCLUSION: Our findings suggest that the educational interventions have more effects on academically educated donors to motivate them to donate plasma.

Physician burnout, a new term, a well-known concept in the medieval era: a thematic review of Ruhawi's Adab al-Tabib.

In 1974, Herbert Freudenberger introduced the phrase 'Burnout in Healing Professional Workers'. Despite the existence of numerous investigations on physician burnout, only a few studies on its historical aspects can be found. This is the first research to present historical evidence on 'physician burnout' as pointed out in the book 'Adab al-Tabib' written by Ruhawi (9th century AD). He is shown to have an understanding of this concept by talking about job stress in his book, although he offers no exact equivalent definition for this state. In fact, finding an equivalent term to 20th century burnout in a book written a thousand years ago is almost impossible. Most interestingly, the same preventive strategies for physician burnout and its causes as those scientifically discovered in recent years can be evidenced to have been introduced by Ruhawi. Hence, 'Adab al-Tabib' is an outstanding work on physician burnout in the medieval era.

EFFECTS OF ACTIVATED-CARBON-FABRIC PARAMETERS ON RESPONSE OF A NEW POLYCARBONATE-BASED INDIVIDUAL AND ENVIRONMENTAL RADON MONITOR.

A new multi-purpose polycarbonate track detector (PCTD)/activated-carbon-fabric (ACF) radon monitor has been recently developed in our laboratory, a basic design of which was used for parametric studies. One 500 µm thick PCTD (3 cm x 3 cm) is used bare for detecting alphas from radon and progeny directly from air and another PCTD (3 cm x 3 cm) covered by an ACF layer (PCTD/ACF) to enhance the PCTD response by radon adsorption on its carbon active sites. The PCTDs were processed by 50 Hz-2 kV electrochemical etching method. The ACF/PCTD sensitivity was enhanced in respect to the PCTD/bare with an amplification factor (AF) defined as ratio of track density on PCTD under ACF to that of PCTD bare. Many ACF-related parameters studied affect the PCTD/ACF response among them thermal annealing of ACF, ACF thickness and distance of ACF layer to the PCTD are reported and discussed in this paper.

Hypoallergenic diet may control refractory epilepsy in allergic children: A quasi experimental study.

Recent data has suggested a definitive role for inflammatory processes in the pathophysiology of epilepsy. In this study we hypothesized that food allergies, as chronic inflammatory processes, underlie the pathophysiology of refractory idiopathic epilepsy and investigated whether food elimination diets may assist in managing refractory epilepsy. The study was conducted on 34 patients up to 16 years of age with refractory convulsions who attended the Allergy Outpatient Clinic, Mofid Children Hospital between 2015 and 2016 with youngest and oldest participants at ages of 3 months and 16 years old, respectively. The participants were categorized into three groups according to the results of skin prick test and serum specific IgE measurements. Elimination diets were instituted for the patients with non IgE-mediated and mixed food allergies. The study was conducted for a period of 12 weeks. The participants were assessed for at least 50% reduction in number of seizures following the intervention. There was a significant reduction in number of seizures (p < 0.001) following the intervention. Seventeen patients (50%) did not experience any seizures after 8 weeks of treatment and 12 patients (35%) had a significant (51-99%) decrease in the number of their seizures. Five patients did not show any changes in their daily seizure frequency. The obtained data suggest that food allergy may play a role in triggering refractory epilepsies and their adequate response to treatment. A trial of elimination diet showed more than 50% seizure reduction in more than 85% of the children studied. However, we believe these results are preliminary and they motivate a fully controlled study in the future.

UNIVERSAL RADIATION PROTECTION SYSTEM (URPS); A NATURAL GLOBAL STANDARDISED TREND FOR HUMAN EXPOSURE CONTROL IN 21st CENTURY.

In order to address the many deficiencies with current radiological protection system worldwide, this paper proposes a new Universal Radiation Protection System (URPS) Hypothesis with novel philosophy, concepts and methodologies of applying principles of equal human health-effect risks of an individual per unit radiation dose either from environmental natural background (NBG) or man-made sources; a 'standardised integrated dose system' for integrating all individual doses with emphasis on national NBG doses; considering worker as a member of public; and a 'cause-effect conservation principle' for epidemiology risk estimation. The URPS also a radiation hypothesises fractionation weighting factors (WF); a 'URPS Model' for bridging 'linear no-threshold and hormesis models'; example dose limit for workers; as well as new terms and definitions. State-of-the-art developments on URPS hypothesis are presented and discussed with simple global natural trends for standardised human exposure control in order to protect workers, patients, public and environment by standardised methods independent of source and country of origin in the 21st century.

Perception of biological motions is preserved in people with autism spectrum disorder: electrophysiological and behavioural evidences.

BACKGROUND: There have been some controversies over the ability of individuals with autism spectrum disorder (ASD) to perceive biological motion. In this study, we used electroencephalography and behavioural measures (recognition test) to examine whether or not children with ASD can correctly identify biological motion. METHOD: Twenty participants with ASD (mean = 11.3, SD = 2.1 years) and 20 typically developed (TD) participants (mean = 11.4, SD = 2.8 years) participated in the study. They watched videos and point light displays of actions, and their EEG was recorded. Then they answered action recognition test, and their accuracy and response times were recorded. RESULTS: Our findings showed that children with ASD had the same mu suppression as a TD age-matched control group in both point light display and video presentations. Furthermore, the results showed that while TD and ASD groups did not differ in accuracy, ASD participants had a slower reaction time. CONCLUSION: Taken together, our results indicate that the perception of non-emotional BMs is preserved in children with ASD.

Comparison of two DNA extraction protocols from leave samples of Cotinus coggygria, Citrus sinensis and Genus juglans.

High quality DNA is essential for molecular research. Secondary metabolites can affect the quantity and quality DNA. In current research two DNA isolation methods including CTAB and Delaporta (protocols 1 & 2 respectively) were applied in three leave samples from Cotinus coggygria, Citrus sinensis and Genus juglans that their leaves are rich of secondary metabolites. We successfully isolated DNA from C. coggygria, C. sinensis and Genus Juglans using the two protocols described above. Good quality DNA was isolated from C. coggygria, C. sinensis and Genus Juglans using protocol 1, while protocol 2 failed to produce usable DNA from these sources. The highest amount of DNA (1.3-1.6) was obtained from them using protocol 1. As we discovered, procedure 1 may work better for plants with secondary metabolites.

Effect of rhythmic auditory stimulation on gait kinematic parameters of patients with multiple sclerosis.

Purpose: This study aimed to examine the effect of rhythmic auditory stimulation on gait kinematic parameters of patients with multiple sclerosis. Subjects and Methods: In this study, 18 subjects, comprising 4 males and 14 females with Multiple Sclerosis with expanded disability status scale of 3 to 6 were chosen. Subjects were selected by available and targeted sampling and were randomly divided into two experimental (n = 9) and control (n = 9) groups. Exercises were gait with rhythmic auditory stimulation by a metronome device, in addition to gait without stimulation for the experimental and control groups, respectively. Training was carried out for 3 weeks, with 30 min duration for each session 3 times a week. Stride length, stride time, double support time, cadence and gait speed were measured by motion analysis device. Results: There was a significant difference between stride length, stride time, double support time, cadence and gait speed in the experimental group, before and after the training. Furthermore, there was a significant difference between the experimental and control groups in the enhancement of stride length, stride time, cadence and gait speed in favor of the experimental group. While this difference was not significant for double support time. Conclusion: The results of this study showed that rhythmic auditory stimulation is an effective rehabilitation method to improve gait kinematic parameters in patients with multiple sclerosis.

Discriminatory Ability of Visceral Adiposity Index (VAI) in Diagnosis of Metabolic Syndrome: A Population Based Study.

Background Visceral adiposity index (VAI) has been suggested as an index of visceral adiposity. This study was conducted to determine the discriminatory ability of VAI in diagnosis of metabolic syndrome (MetS). Methods and materials We used the data of 5 312 subjects aged 18-74 years of a cohort study conducted among 6 140 individuals aged 10-90 years in Amol, northern Iran. The city population was divided into 16 strata based on gender and age groups in 10-year intervals. The subjects were randomly selected from each stratum. MetS was defined based on National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATPIII), American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) update of Adult Treatment Panel III (ATPIII), International Diabetes Federation (IDF) and joint interim statement (JIS) definitions. The discriminatory ability of VAI and other obesity measures were evaluated using receiver operating characteristic (ROC) curves. Results While waist circumference (WC) showed the highest discriminatory ability for MetS in IDF definition in men (AUC=0.899 [CI=0.888-0.910]), VAI had the greatest discriminatory ability according to other definitions in men and women. The related AUCs of VAI were 0.866 (95%CI: 0.850-0.881), 0.829 (95%CI: 0.813-0.846), 0.859 (95%CI: 0.844-0.873) and 0.876 (95%CI: 0.863-0.889) based on NCEP/ATPIII, AHA/NHLBI update of ATPIII, IDF and JIS definition in men, and also 0.888 (95%CI: 0.875-0.902), 0.894 (95%CI: 0.881-0.907), 0.883 (95%CI: 0.869-0.897) and 0.879 (95%CI: 0.864-0.894) in women, respectively. Conclusion VAI showed an excellent discriminatory ability in diagnosis of MetS. Considering its relatively simple calculation, this index could be suggested as a reliable tool in medical practice.

Effects of a selected exercise programon executive function of children with attention deficit hyperactivity disorder.

Introduction. The aim of this study was to examine the effectiveness of a Selected exercise program on the executive function of children with ADHD. Method. The participants were 40 male students, aged 7-11 years. The participants were randomly assigned into two groups (experimental and control). The experimental group participated in an exercise program for 24 sessions, 90 minutes per session. The control group did not receive any intervention. Before and after the exercise period, all the participants were assessed with Stroop and Go-No-Go tests, and the resulting data were analyzed by using MANCOVA. Result. The results showed that the cognitive inhibition of the children in the experimental group was significantly different compared with the control group (p < 0.05). Additionally, there was a significant difference between the experimental and control groups in the behavioral inhibition (p < 0.05). Conclusion. An organized physical activity helps to improve the executive function in children with ADHD.

Far-infrared tangential interferometer/polarimeter design and installation for NSTX-U.

The Far-infrared Tangential Interferometer/Polarimeter (FIReTIP) system has been refurbished and is being reinstalled on the National Spherical Torus Experiment-Upgrade (NSTX-U) to supply real-time line-integrated core electron density measurements for use in the NSTX-U plasma control system (PCS) to facilitate real-time density feedback control of the NSTX-U plasma. Inclusion of a visible light heterodyne interferometer in the FIReTIP system allows for real-time vibration compensation due to movement of an internally mounted retroreflector and the FIReTIP front-end optics. Real-time signal correction is achieved through use of a National Instruments CompactRIO field-programmable gate array.

Gastric Cancer and Helicobacter pylori: Impact of hopQII Gene.

The Helicobacter pylori is a Gram-negative, microaerophilic bacterium found usually in the stomach and use a number of mechanisms to survive in the stomach lumen. The presence of these bacteria in the stomach can lead to gastritis and reduction in stomach acid production. Acute inflammation can directly damage to the peripheral cells that are responsible for the secretion of acid. The risk of developing gastric carcinoma is associated to heterogeneity of Helicobacter pylori virulence factors. The HopQII is one of the outer membrane proteins involved in bacterial adherence to gastric mucosa and has been suggested to also play a role in the virulence of H. pylori. The purpose of the current study was to investigate the association between different H. pylori virulence hopQII allele and patients with gastroduodenal disorders. For this purpose 58 stomach biopsies of patients with gastric cancer and 100 saliva samples from healthy individuals were collected. Then genomic DNA was purified and PCR for was done for desired genes via specific primers. The H. pylori infections were diagnosed by PCR for GlmM gene. Then frequencies of hopQII+ and hopQII- genotypes was determined in H. pylori infected cases. Statistical analysis showed that there were not significant differences between healthy and diseased ones for genotype hopQII+.

Association between Helicobacter pylori hopQI genotypes and human gastric cancer risk.

The Helicobacter pylori use a number of mechanisms to survive in the stomach lumen and can lead to gastritis and reduction in stomach acid secretion. It has been found that the risk of developing gastric carcinoma is associated to heterogeneity of H. pylori virulence factors such as HopQ. The HopQ is one of the outer membrane proteins involved in bacterial adherence to gastric mucosa and has been suggested to also main role in the virulence of H. pylori. The purpose of the current study was to investigate the association between different H. pylori virulence hopQI (types I) genotyping and patients with gastroduodenal disorders. For this purpose 58 stomach biopsies of the patients with gastric cancer and 100 saliva samples from healthy and H. pylori infected individuals were collected and studied. Then genomic DNA was purified and PCR was done for desired gene via specific primers. The H. pylori infections were diagnosed using PCR for GlmM gene. Then frequencies of hopQI+ and hopQI- genotypes were determined in H. pylori infected cases. Statistical analysis showed that there were not significant differences between healthy and diseased ones for genotypes hopQI+ and hopQI-. Then the hopQI+ cannot be as a risk factor genotype for gastric cancer.

BACKGROUND TRACK DENSITY REDUCTION OF 50-HZ-HV ECE-PROCESSED THICK POLYCARBONATE DETECTORS TO IMPROVE LOWER DETECTION LIMIT.

A recent novel development of 50-Hz-HV ECE of 1-mm-thick and 250-µm-thick polycarbonate track detectors (PCTDs) has proved some promising results for some health physics, dosimetry and ion-beam-related applications. The method while proved having some good characteristics for some applications provided a relatively higher background track density (BGTD) in particular when very high voltages are applied to the PCTDs. In order to decrease the minimum detection limit (MDL) of the PCTDs and to further promote its applications for low dose, the BGTD was reduced by applying a layer removal methodology applying ethylendiamine (EDA). The effects of EDA concentrations (50, 60, 65, 70, 75, 80, 85 and 90 %) in water at room temperature (26°C) and soaking durations up to 100 min at different EDA concentration on BGTD reduction were studied. The thickness of the layer removed from the surface of a PCTD highly depends on the soaking time and EDA concentration; it increases as the EDA concentration increases up to for example 700 µm after 2 h of soaking in the EDA solution. After ∼10 min of soaking duration at any of the above-stated concentrations, the BGTD reaches its minimum value, a value which differs from concentration to concentration. An EDA concentration of 85 % in water provided the lowest BGTD of 64.06 ± 3.12 tracks cm- 2; ∼6 times lower than that of its original value. It is shown that the layer removal process does not change the registration characteristics of the PCTD and its appearance significantly. The MDL of the PCTDs depends strongly on the BGTD. The MDL values for a desired confidence level were also studied by three calculation methods. The results of the BGTD and the MDL studies under different conditions applied are presented and discussed.

Relation of intelligence quotient and body mass index in preschool children: a community-based cross-sectional study.

OBJECTIVE: Overweight and obesity in children is a global problem. Besides physical effects, obesity has harmful psychological effects on children. METHODS: We carried out cross-sectional community-based study to investigate the relation between body mass index (BMI) and cognitive functioning in preschool children. Thirteen socioeconomical elements of 1151 children were measured and analyzed based on their intelligence quotient (IQ) test results. Thirteen out of 33 provinces were selected randomly, and schools were selected as clusters in rural and urban areas. Descriptive statistics, t-test, analysis of variance and regression were used when appropriate. RESULTS: Our analysis showed that IQ was associated with household income, place of residence, delivery type, type of infant feeding and father's and mother's education level (P<0.001 for all). Using penalized linear regression for eliminating the impact of confounding factor, our study shows that, living in metropolitan (ß=2.411) and urban areas (ß=2.761), the level of participants' father's education (ß=5.251) was positively and BMI (ß=-0.594) was negatively related with IQ test results.ConclusionsThe findings of the present study showed that a lower IQ score is associated with higher BMI. However, this relation appears to be largely mediated when the socioeconomic status was considered.

A new two-phase media method for 226Ra activity measurement in water.

A new two-phase media method was developed for determination of (226)Ra activity in water. The method was calibrated by applying 7 standard (226)Ra waters with known activities. The method detects alphas in two media; 80 ml of water in a glass bottle with air or a non-polar liquid such as olive oil on top of the water. Alpha particles from (226)Ra, (222)Rn and progeny were detected by two polycarbonate track detectors (PCTDs) which were mounted on a holder inserted in the bottle so that one PCTD is placed in water and the other in air or in the non-polar liquid. The bottles were hermetically sealed and kept for 40 or 48 d. The PCTDs in the bottles shaken every other day enhanced the sensitivity of the measurements. The Calibration Factors for the standard (226)Ra waters, air and olive oil above water are, respectively, (7.85 ± 0.25) × 10(-3), (7.94 ± 0.13) × 10(-3) and 3.02 × 10(-2) tracks.cm(-2) kBq(-1) h(-1) m(3).