ABSTRACT
A 45 year-old woman presented with late-diagnosed celiac disease, marked disorders of calcium and bone metabolism, and severe osteoporosis. Weak enteral symptoms delayed diagnosis. High efficiency of agluten and vitamin D therapy was documented.
Subject(s)
Celiac Disease/diagnosis , Duodenum/pathology , Endoscopy, Gastrointestinal/methods , Biopsy , Bone Density Conservation Agents/therapeutic use , Celiac Disease/complications , Celiac Disease/therapy , Delayed Diagnosis , Diagnosis, Differential , Diet, Gluten-Free , Female , Humans , Middle Aged , Osteoporosis/diagnosis , Osteoporosis/etiology , Vitamin D/therapeutic useABSTRACT
AIM: The study of duodenal morphology in children and adolescents with skeletal deformity. MATERIALS AND METHODS: Clinical, hormonal examinations, x-ray investigation of the skeleton with spinal NMR-tomography, gastroduodenoscopy with target biopsy were performed in 41 patients aged 7 to 18 on after treatment for broken spine. RESULTS: Atrophic duodenitis found in most of the patients presented without dyspepsia, with symptoms of duodenitis in 8 patients, osteoporosis in 36% of patients. NMR-tomography rejected compression-broken spine in 22 patients. CONCLUSION: Disturbed absorption of calcium and atrophic alterations in the duodenal mucosa are thought responsible for disturbance of calcium metabolism and formation of bone tissue.
Subject(s)
Bone Diseases, Metabolic/pathology , Duodenum/pathology , Adolescent , Biopsy , Bone Diseases, Metabolic/diagnosis , Bone Diseases, Metabolic/etiology , Bone Diseases, Metabolic/physiopathology , Child , Duodenum/physiopathology , Endoscopy, Gastrointestinal , Female , Humans , Male , Spinal Fractures/complications , Spinal Fractures/diagnosis , Stomach/pathology , SyndromeSubject(s)
Osteoporosis, Postmenopausal/drug therapy , Aged , Calcium/metabolism , Drug Combinations , Estradiol/administration & dosage , Estradiol/analogs & derivatives , Female , Humans , Middle Aged , Osteoporosis, Postmenopausal/metabolism , Testosterone/administration & dosage , Vitamin D/therapeutic useABSTRACT
Electrolytic imbalance is a frequent finding in malabsorption syndrome. Derangement of calcium metabolism present clinically in different variants is most serious. Some patients develop hypocalcemia manifesting clinically with specific myasthenia, paresthesias, convulsions, hemorrhages, etc. In other variants severe skeletal lesions are seen which may become dominating in the clinical picture though hypocalcemia was absent. Investigation of calcium metabolism, hormonal profile (parathormone, in particular) in malabsorption syndrome can prognosticate and prevent the onset of osteomalacia.
