ABSTRACT
The study established that shifts in oxidant-antioxidant system induced by chronic obstructive bronchitis are correctable by He-Ne laser irradiation. This conclusion was based on biochemical indices of the blood measured in experimental animals: lipid peroxidation, general antitryptic activity of the serum, activity of the enzymes superoxide dismutase, gamma-glutamyl transferase, pseudocholine esterase, alpha-oxybutyrate dehydrogenase, glucose 6-phosphate dehydrogenase.
Subject(s)
Antioxidants , Bronchitis/radiotherapy , Laser Therapy , Animals , Biochemical Phenomena , Biochemistry , Bronchitis/blood , Butyrylcholinesterase/blood , Glucosephosphate Dehydrogenase/blood , Hydroxybutyrate Dehydrogenase/blood , Lipid Peroxidation , Rats , Superoxide Dismutase/blood , gamma-Glutamyltransferase/bloodABSTRACT
The authors investigated the clinical and biochemical efficacy of millimeter-wave resonance therapy in patients with destructive pulmonary tuberculosis associated with different concomitant diseases. It was established that inclusion of millimeter-wave resonance therapy in the complex treatment of this patient category favoured the efficacy of tuberculosis treatment. The treatment produced also a favourable effect on concomitant diseases.
Subject(s)
Microwaves/therapeutic use , Tuberculosis, Pulmonary/therapy , Combined Modality Therapy , Drug Therapy, Combination , Humans , Remission Induction , Tuberculosis, Pulmonary/complicationsSubject(s)
Bronchitis/therapy , Diathermy , Microwaves/therapeutic use , Tuberculosis, Pulmonary/therapy , Adult , Bronchitis/complications , Bronchitis/metabolism , Chronic Disease , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Oxidation-Reduction , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/metabolismABSTRACT
The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.
Subject(s)
Antitubercular Agents/administration & dosage , Isoniazid/administration & dosage , Maleates/administration & dosage , Succinates/administration & dosage , Tuberculosis, Pulmonary/drug therapy , Animals , Delayed-Action Preparations , Drug Evaluation, Preclinical , Drug Therapy, Combination , Guinea Pigs , Male , Organic Chemicals , Succinic AcidSubject(s)
Isoniazid/therapeutic use , Animals , Delayed-Action Preparations , Drug Evaluation, Preclinical , Guinea Pigs , Isoniazid/pharmacokinetics , Isoniazid/toxicity , Lethal Dose 50 , Liver/pathology , Lung/pathology , Male , Tissue Distribution , Tuberculosis/drug therapy , Tuberculosis/mortality , Tuberculosis/pathologyABSTRACT
Effects of isoniazide and of new tuberculostatic drug of long-term action on functions of guinea pig liver mitochondria were studied in experimental tuberculosis. Significant changes in oxidative phosphorylation were found. The combination of sodium succinate with tuberculostatic drugs improved the bioenergetic functions of liver mitochondria under the conditions of antibacterial therapy of experimental tuberculosis.
