Subject(s)
Communicable Disease Control , Vaccination , Child , Child, Preschool , Humans , Infant , USSR , Vaccination/adverse effectsABSTRACT
The results of the clinico-laboratory and epidemiological study of a newly developed live measles vaccine obtained from strain Moscow-5, genetically homogeneous and cloned from strain JI-16, are presented. The data indicate that the vaccine obtained from strain Moscow-5 is safe and possesses low reactogenicity and high immunological potency, thus meeting all requirements for vaccinal preparations.
Subject(s)
Antibodies, Viral/analysis , Measles Vaccine/immunology , Measles virus/immunology , Measles/immunology , Adolescent , Animals , Child , Child, Preschool , Coturnix , Embryo, Nonmammalian , Female , Follow-Up Studies , Humans , Infant , Measles/prevention & control , Serology/methods , Time FactorsSubject(s)
Pneumonia/diagnosis , Acute Disease , Adolescent , Child , Child, Preschool , Diagnosis, Differential , Diagnostic Errors , Humans , Infant , Pneumonia, Viral/diagnosisSubject(s)
Encephalomyelitis, Acute Disseminated/etiology , Encephalomyelitis, Autoimmune, Experimental/etiology , Smallpox Vaccine/adverse effects , Vaccination/adverse effects , Child, Preschool , Dose-Response Relationship, Immunologic , Electroencephalography , Encephalomyelitis, Acute Disseminated/physiopathology , Encephalomyelitis, Autoimmune, Experimental/physiopathology , Humans , Smallpox Vaccine/administration & dosage , Time Factors , Vaccination/methodsSubject(s)
Croup/chemically induced , Laryngitis/chemically induced , Tonsillitis/chemically induced , Vaccination/adverse effects , Child , Child, Preschool , Croup/immunology , Croup/microbiology , Encephalomyelitis, Acute Disseminated/immunology , Encephalomyelitis, Acute Disseminated/microbiology , Humans , Infant , Smallpox Vaccine/adverse effects , Time Factors , Tonsillitis/immunology , Tonsillitis/microbiology , Variola virus/isolation & purificationABSTRACT
As a result of observations carried out on children the authors present immunological characteristics of two-stage smallpox vaccination at different intervals (1 to 60 days) between the injection of inactivated and live vaccine. There proved to be acceleration and intensification of antibody formation after two-stage immunization in comparison with the rutine vaccination. A seven-day interval between the injection of the inactivated and live preparations was recommended on the basis of the data obtained.