[An outbreak of nosocomial candidiasis in a hematology ward]. / Vspyshka vnutribol'nichnogo kandidoza v gematologicheskom otdelenii.

The aim of the present investigation was the study of the epidemic process of hospital candidiasis. The study was carried out from October 1991 to May 1992 in a hematological ward of one of the hospitals of St.-Petersburg on 9 patients with generalized forms of candidiasis: in 4 of them the disease was caused by C. albicans and 5--by C. parapsilosis. Intestinal dysfunction as one of the first manifestations of candidosepsis caused by C. albicans, the isolation of C. albicans from feces, ulcero-necrotic colitis (established by postmortem examination), as well as the incapacity of these patients of immune response (in 2 serologically examined patients the titer of antibodies to fungi of the genus Candida was found to be lower than the diagnostic titer), were indicative of the dissemination of fungi from the gastrointestinal tract. The cases of fungemia caused by C. parapsilosis were due to the fungal contamination of vascular catheters in these patients. This infective agent was also isolated from washings obtained from the hands of nurses carrying out treatment and from medical rubber gloves. Moreover, some violations in the rules of the preparation of disinfecting solutions and the treatment of the hands of the personnel were established.

[Effect of chronic pathology of the upper cervical sympathetic ganglion on the cerebral cortex (experimental study)]. / O vozdeistvii khronicheskoi patologii verkhnego sheinogo simpaticheskogo gangliia na koru mozga (éksperimental'noe issledovanie)]

A study was made of the character of disorders of glycogen metabolism and dynamics of the glycogen synthetic properties of sensorimotor cortical neurons at different stages of dystrophic processes under chronic irritation of the anterior cervical ganglion. The authors demonstrate the local glycogen synthesis in synapse ultrastructures, which is of paramount importance for local homeostasis, ensuring high plasticity and dynamism of cortical synapses in information transmission. Decimetric radiotherapy revealed that the sclerosed sympathetic ganglion exerts a permanent tonic effect on the regulation of intracerebral vessels. It may be assumed that control of sympathetic fibers from the cervical ganglion is aimed to a definite measure at specialized regulation of energy brain supply.

[Functional status of the endocrine and immune systems in women with chronic candidiasis of external genital organs]. / Funktsii éndokrinnoi i immunnoi sistem pri khronicheskom kandidoze naruzhnykh genitalii u zhenshchin.

Sixty three patients with chronic candidiasis of external genitalia (CCEG) were studied. There was no evidence of hypoparathyroidism or adrenal failure in females with CCEG. The possible role of documented hypothyroidism or diabetes mellitus in these patients' condition should be considered. Though the impairment of the B-or T-immune systems failed to be revealed in the aforementioned patients, some of them demonstrated autoimmune processes in some endocrine glands without any significant impairment of their functional performance.

[Functional characteristics of the endocrine and immune systems in patients with visceral candidiasis]. / Nekotorye funktsional'nye kharakteristiki éndokrinnoi i immunnoi sistem u bol'nykh vistseral'nym kandidozom.

A study was made of pituitary, thyroid, parathyroid, endocrine pancreatic, adrenocortical and immune system functions in 56 patients afflicted with visceral candidiasis. The clinical and laboratory data obtained point to the presence in some patients with visceral candidiasis of parathyroid, thyroid, pancreatic and adrenocortical dysfunctions, attesting to their importance in the disease pathogenesis. The role of immune disorders, particularly that of the T component of the immunity system is found to be of paramount importance as well in the pathogenesis of candidiasis. Correction of endocrine disorders coupled with antimycotic therapy brought about a more rapid and steadier therapeutic effect.

[Glycogen metabolism in the cranial cervical ganglion of the cat sympathetic trunk during decentralization and reparative regeneration]. / Metabolizm glikogena v kranial'nom sheinom uzle simpaticheskogo stvola koshki v usloviiakh detsentralizatsii i pri reparativnoi regeneratsii.

The character of glycogen metabolism disorders has been studied in the cranial cervical ganglion of the cat sympathetic trunk after the latter has been cut 1.5 cm caudally the ganglion. As the innervational connections are establishing, the glycogen metabolism is normalizing, but even after 2 months the initial level is not restored. Glycogen is proved to be one of the most sensitive tests to the lesion. In various time after cutting, the glycogen metabolism has certain specific peculiarities both in the neural cell bodies, and in the synapses. The wavy character of the glycogen-synthesizing process in the neural elements is demonstrated, with anaerobic glycolysis taking a large part in it. Certain connections with the higher centers are necessary not only for glycogen metabolism as energy resources, but to ensure a regular synthesis, particularly that of enzymes, in the neurons and synapses. The peculiarities of glycogen-synthesizing properties in the synaptic formations, after the connection with the center is broken, are closely connected with the notion on autonomity in the synaptic structures activity.

[Glycogen metabolism of neuronal systems of the spinal cord in experimental ischemia]. / Glikogenovyi metabolizm neironnykh sistem spinnogo mozga pri éksperimental'noi ischemii.

The authors carried out histochemical determinations of the glycogen level and the activity of some enzymes controlling carbohydrate metabolism (glycogen transferase and phosphorylase, succinate dehydrogenase) in the lumbar segments of the spinal cord of 40 animals (cats) with circulatory ischemia caused by aorta ligation. The examinations were performed at different periods of time after the ischemia induction under conditions of carbohydrate load. In the course of the pathological process development because of the ischemia (within a period ranging from 6 hours to 26 days) considerable variations of the glycogen-synthetizing capacities of the spinal cord nervous elements were revealed. These variations were of a periodic character. The number of glycogen-containing cells was maximal within a period ranging from the 2nd to the 10th day: this correlated with the highest enzymatic activity in this period. The glycogen content in a cell and the degree of the latter's damage were found to be in an inverse relationship. It is shown that different resistance of the nervous elements to hypoxia is determined to a great measure by their capacity to synthetize and deposit glycogen. Thus, the glycogen metabolism, being a specific compensatory-adaptive mechanism of the nervous tissue, is, thereby, a material basis of its vital activity.