ABSTRACT
Hereditary neutropenia is a rare and poorly known condition leading to severe infectious complications and other pathologies; specifically, it is sometimes associated with the development of tumours. Literature data on clinical manifestations and possible pathogenetic mechanisms of the disease are discussed. A case report of idiopathic neutropenia and concomitant T-cell lymphoma is presented.
Subject(s)
Lymphoma, T-Cell/etiology , Neutropenia/congenital , Antineoplastic Agents/therapeutic use , Biopsy , Bone Marrow/pathology , Diagnosis, Differential , Disease Progression , Female , Humans , Lymphoma, T-Cell/diagnosis , Lymphoma, T-Cell/drug therapy , Middle Aged , Neutropenia/complications , Neutropenia/diagnosis , Tomography, X-Ray ComputedABSTRACT
The ability of leukocytes to generate active oxygen forms and plasmic levels of malonic dialdehyde as indicators of free radical process activity and that of lipid peroxidation (POL), respectively, were investigated in 50 patients with angina pectoris (20 patients with functional class I-II and 30 patients with functional class III-IV) versus 18 donors. The anginal patients are shown to have enhanced POL and free radical processes which appeared correlated with the disease severity. The authors identify factors intensifying free radical processes in anginal patients: platelet inhibition of leukocytic ability to generate active oxygen forms, changes in plasmic levels of IgM, C-reactive protein, serum iron.
Subject(s)
Angina Pectoris/blood , Myocardial Ischemia/blood , Adult , Aged , Blood Platelets/metabolism , Female , Free Radicals , Humans , Leukocytes/metabolism , Lipid Peroxidation , Male , Malondialdehyde/blood , Middle Aged , Physical ExertionABSTRACT
The paper is concerned with studies on generation of free radicals by donor leukocytes in plasma rich or poor in platelets. NBT test and chemiluminescence were employed. Platelets are shown to inhibit generation of free radicals. Changes in free radicals generation were studied under stimulation by zymosan and addition of washed platelet fraction. The conclusion is made that platelets inhibit leukocyte generation of free radicals by adsorption factors necessary for this process from plasma.
