[Development of diabetes mellitus in the progeny of 6 generations of female rats with alloxan diabetes]. / Razvitie sakharnogo diabeta u potomstva krys-samok s alloksanovym diabetom v 6 izuchennykh pokoleniiakh.

The development of diabetes mellitus has been studied in six progeny generations of female Wistar rats with alloxan diabetes coupled with normal males. An increased incidence of diabetes and its higher degree have been observed in younger generations studied. A correlation has been established between the frequency of diabetic type of glucose tolerance and hypoglycemia in rats of the first generation during the first month of their postnatal life, and the incidence of diabetes in the progeny of mother rats from the older generations.

[Mechanisms of sexual dysfunction in alloxan diabetic rats]. / Mekhanizmy narusheniia polovoi funktsii pri alloksanovom diabete u krys.

The hypophysis weight significantly rises in male and female rats suffering from mild alloxan diabetes (prediabetes and the latent disease form). In pronounced diabetes, a decrease in the hypophysis weight is seen. These changes do not correlate with alterations in sex function which is essentially deranged only in pronounced diabetes mellitus when the blood levels of luteinizing hormone (LH), testosterone and estradiol are reduced and the weight of the reproductive organs (prostate and uterus), dependent on the above blood hormone levels, decreases. These indices remain unchanged in prediabetes and the latent diabetes form. In marked diabetes, a rise in gonadotropin-releasing hormone level in the hypothalamic arcuate body is seen that may be indicative of lowering gonadotropin-releasing hormone secretion into the blood rather than of its synthesis reduction in peptiergic neurons. These disturbances are supposed to be primary link in sex dysfunction development in diabetes.

[Dopamine, noradrenaline and serotonin content in various parts of the hypothalamus in alloxan diabetes]. / Soderzhanie dofamina, noradrenalina i serotonina v razlichnykh otdelakh gipotalamusa pri alloksanovom diabete.

In male rats with various forms of alloxan diabetes ("prediabetes", latent and manifest diabetes) there was revealed an increase in noradrenaline level in the anterior and the medial-basal hypothalamus. A rise of dophamine content was noted in the hypothalamus of these animals. Serotonin level fell in all the parts of the hypothalamus of males with "prediabetes". The level of immunoreactive insulin on fasting stomach was diminished in manifest alloxan diabetes, particularly in its severe forms. The data obtained suggest the importance of the feedback mechanism between the metabolic disturbances as a result of insulin insufficiency and the changes in the monoamines level in the hypothalamus. The role of certain parts of the hypothalamus in the regulation of insulin secretion is stressed.

[Histopathological changes in the kidneys of the progeny of rats with aloxan diabetes]. / Patogistologicheskie izmeneniia v pochkakh u potomstva krys-samtsov s allokanovym diabetom.

A histological study (hematoxylin-eosin staining, and PAS-reaction) of the kidneys was carried out in 5 pubertal rats with diabetic test for glucose tolerance from the progeny of a female with alloxan diabetes and intact male. Changes of the type of diabetic intracapillary glomerulosclerosis were revealed. There were no changes in the kidneys of pubertal rats from the progeny of intact female and male, and an intact female and a male rat with alloxan diabetes.

[UDPG pyrophosphorylase and phosphoglucomutase activity in the liver of rats with alloxan diabetes]. / Aktivnost' UDFG-prifosforilazy i fosfogliukomutazy v pecheni krys pri alloksanovom diabete.

The UDPH-pyrophosphatase and phosphomurase activity was determined in the liver homogenates of rats with manifest alloxan diabetes. In comparison with control animals, there was a statistically significant reduction of UDPH-pyrophosphorylase and phosphoglucomutase activity (by 29 and 33%, respectively) in diabetic rats. Decreased activity of the mentioned enzymes in the liver of rats with alloxan diabetes pointed to their participation in reduction of glycogen synthesis in the liver occurring in this disease.

[Placental ultrastruct in rats with experimental diabetes mellitus]. / Ul'trastruktura platsenty krys pri éksperimental'nom sakharnom diabetom.

The placenta of Wistar rats with various forms of diabetes mellitis was studied by electron microscopy. Metabolic disturbances characteristic of alloxan diabetes mellitus failed to derange the trophoblast ultrastructure during the existence of placenta and produced no changes in the ultrastructure of the fetal vessels similar to the changes in the capillary ultrastructure of other organs and tissues in this pathology.

[Placental permeability in experimental diabetes mellitus]. / Pronitsaemost' platsenty pri eksperimental'nom sakharnom diabete.

The work was performed on female rats to which alloxan was administered at immature age. Placental permeability was studied in female rats, healthy ones (170 fetuses), with prediabetes (124 fetuses), with latent diabetes (102 fetuses), and with manifest diabetes (112 fetuses). Permeability of placental membrane was assessed by means of the fluorimetric method of determination in the fetal organism of uranin, a stain administered into the blood of a pregnant animal. The results of the investigations demonstrated that in rats with alloxan prediabetes, latent and manifest diabetes permeability of placental membrane showed a significant elevation (P less than 0.001). There was revealed a direct relationship between the extent of the insular insufficiency and permeability of the placental membrane.

[Sensitivity of adipose tissue to insulin in latent diabetes mellitus (a clinico--experimental study)]. / Chuvstvitel'nost' zhirovoi tkani k insulinu pri skrytykh formakh sakharnogo diabeta (kliniko-éksperimental'noe issledovanie).

A study was made of the sensitivity of adipose tissue to insulin in patients with latent diabetes mellitus and in rats with latent alloxan diabetes. Investigations were carried out by the intensity of glucose-C-14 incorporation into total lipids of adipose tissue during its incubation with various insulin concentrations. It was demonstrated that in rats with latent alloxan diabetes sensitivity of adipose tissue to insulin was unchanged in comparison with control rats. Sensitivity of adipose tissue to insulin was significantly reduced in the patients with latent diabetes mellitus in comparison with control. The data obtained indicated that reduction of the sensitivity of adipose tissue to insulin in patients with latent diabetes mellitus served as a primary factor in the pathogenesis of diabetes mellitus, responsible for the appearance of a relative insulin deficiency.