ABSTRACT
Suitability of four arylosulfonic acids and their sodium salts to form derivatives with hypotensive drugs were studied. New crystalline arylosulfonates of todralazine, hydralazine and dihydralazine were obtained. Physico-chemical properties of the obtained arylosulfonates were tested. Reagents mentioned above were also used in analysis of these drugs.
Subject(s)
Antihypertensive Agents/analysis , Dihydralazine/analysis , Hydralazine/analysis , Sulfonic Acids/analysis , Todralazine/analysisABSTRACT
Suitability of three phenylsulphonyloxybenzenesulfonic acids and their sodium salts to form new derivatives with antidepressive drugs were studied. Then physicochemical properties of the obtained arylosulfonates were tested. Reagents mentioned above were also used in analysis of these drugs.
Subject(s)
Antidepressive Agents/analysis , Arylsulfonates/analysis , Arylsulfonates/chemistry , Dihydralazine/analysis , Hydralazine/analysis , Indicators and Reagents , Todralazine/analysisABSTRACT
The new immunosuppressive and anti-inflammatory agents have been searched in a group of the synthetic L-cysteine and 3-acetyl-thiazolidine-4-carboxylic acid derivatives. Synthesis of 17 compounds is reported.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Cysteine/analogs & derivatives , Immunosuppressive Agents/chemical synthesis , Thiazoles/chemical synthesis , Cysteine/chemical synthesis , Cysteine/immunology , Thiazoles/immunologyABSTRACT
In continued search for new compounds with immunotropic and anti-inflammatory activity we developed synthesis of the seven following new derivatives of L-cysteine: S-methyl-N-acetylcysteine amide, hydrazide and acetylhydrazide, acetyl derivatives of S-methyl-N-acetylcysteine methylhydrazide, S-methylcysteine morpholineamide and S-methyl-N-acetylcysteine morpholineamide. In general the syntheses consisted in obtaining esters of cysteine and S-methylcysteine, which were submitted to aminolysis and the obtained derivatives were acetylated with acetic anhydride. S-Methylcysteine morpholineamides were obtained by condensation of morpholine with cysteine derivatives by carbodiimied and/or mixed anhydride method. Yields of the compounds were high. Elemental composition was confirmed by elementary analysis.
Subject(s)
Anti-Inflammatory Agents/chemical synthesis , Cysteine/analogs & derivatives , Immunosuppressive Agents/chemical synthesis , Cysteine/chemical synthesis , Structure-Activity RelationshipABSTRACT
Working on the problem entitled "Synthesis of cysteine derivatives of immunotropic activity" the following compounds were synthesized; cysteine hydrazide and its hydrochloride, S-methylcysteine hydrazide hydrochloride, S, N, N-trimethylcysteine and S-benzylcysteinyl-S-benzylcysteine. We modified the synthesis of cysteine hydrazide and prepared its hydrochloride. This way a better yield and simplification of the synthesis were achieved. The above compounds were obtained with good yields.
