Anisotropic 2-D and 3-D averaging of fMRI signals.

A novel method for denoising functional magnetic resonance imaging temporal signals is presented in this note. The method is based on progressively enhancing the temporal signal by means of adaptive anisotropic spatial averaging. This average is based on a new metric for comparing temporal signals corresponding to active fMRI regions. Examples are presented both for simulated and real two and three-dimensional data. The software implementing the proposed technique is publicly available for the research community.