Subject(s)
Humans , Male , Adult , Folliculitis/drug therapy , Clindamycin/therapeutic use , Rifampin/therapeutic use , Administration, TopicalABSTRACT
BACKGROUND: Radiotherapy as a first-choice treatment for in situ extramammary Paget disease has been successfully used. OBJECTIVES: To review the most relevant aspects of radiotherapy as first-choice treatment in selected cases of in situ extramammary Paget disease of the vulva. PATIENTS AND METHODS: Two Caucasian females aged 76 and 92 years with in situ extramammary Paget disease localized in the genital region were treated by means of ortovoltage X-rays: 100 kV, 8 mA, 1.7 mm Al filter, field size of 12-cm cone, and source skin distance of 30 cm. Both patients received 40 Gy, 200 cGy per fraction, five fractions per week. RESULTS: Complete regression of in situ extramammary Paget disease was observed in both patients after radical radiation therapy and neither local recurrences nor internal malignancies were detected. CONCLUSIONS: Radiotherapy is a curative treatment in selected cases of in situ extramammary Paget disease affecting the vulva.
Subject(s)
Paget Disease, Extramammary/radiotherapy , Vulvar Neoplasms/radiotherapy , Aged , Aged, 80 and over , Female , Humans , Paget Disease, Extramammary/pathology , Radiation Dosage , Vulvar Neoplasms/pathologyABSTRACT
Discromic neurocutaneous syndromes are an heterogeneous group of genetic diseases which associate pigmentary anomalies to nervous system disturbances. Development of molecular biology has allowed a better understanding and classification of this diseases. In this article we review this entities with an emphasis on the last clinical and genetic discoveries.
Subject(s)
Pigmentation Disorders/genetics , Skin Neoplasms/genetics , Angiofibroma/genetics , Angiofibroma/pathology , Female , Humans , Male , Neurofibromatoses/genetics , Neurofibromatoses/pathology , Pigmentation Disorders/pathology , Skin Neoplasms/pathology , Syndrome , Tuberous Sclerosis/geneticsABSTRACT
Syringomas localized in the genital areas are unusual. There are only three cases reported describing syringomas on the penis. Owing to this atypical localization it is necessary to consider a differential diagnosis involving other papular lesions more frequent found on the penile skin.
Subject(s)
Adenoma/pathology , Penile Neoplasms/pathology , Sweat Gland Neoplasms/pathology , Adult , Diagnosis, Differential , Humans , Male , Penis/pathology , Sweat Glands/pathologyABSTRACT
We present the case of a 64 year-old-male fur trader from Lerida (Spain), who consulted us because of a 2-week history of night fever and the presence of non-pruritic purpuric lesions on the distal third of the lower limbs. Laboratory findings demonstrated positive serology for brucellosis and cutaneous biopsy showed leukocytoclastic vasculitis. The pathogenesis of the cutaneous process is discussed. We also suggest that brucellosis should be included among the infections taken into account in patients suffering from leukocytoclastic vasculitis coming from brucella-endemic areas.
