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1.
J Cell Mol Med ; 28(4): e18125, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38332520

ABSTRACT

The underlying mechanisms mycosis fungoides (MF)-related pruritus remain unclear, and the link between pruritus and systemic inflammation in MF is unexplored. We aimed to investigate systemic inflammation in MF patients and its potential connection to pruritus. In this retrospective study, demographic characteristics, MF stage, clinical and laboratory findings, and neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI) and pan-immune inflammation value (PIV) were assessed for all participants. Additionally, mSWAT scores, Dermatology Life Quality Index (DLQI), and pruritus presence and intensity via Visual Analogue Scale (VAS) scoring were recorded for MF patients. A total of 81 patients with early-stage MF and 50 controls were enrolled. Itching was present in 41 patients (50.6%). NLR, PLR, SII, SIRI and CRP values in the MF group were significantly higher. CRP, NLR, mSWAT and DLQI score were significantly higher in MF patients with pruritus than those without. Pruritus was positively correlated with DLQI, mSWAT, CRP, NLR, MLR and SIRI. VAS score was positively correlated with eosinophil count and DLQI. In the multivariate logistic regression model, only NLR was an independent and significant associate of pruritus in patients with MF. This study provides evidence of enhanced systemic inflammation in early-stage MF patients. Additionally, the correlation between pruritus with mSWAT scores and systemic inflammation parameters suggests a potential link between pruritus and the inflammatory milieu in MF.


Subject(s)
Mycosis Fungoides , Skin Neoplasms , Humans , Retrospective Studies , Mycosis Fungoides/complications , Inflammation/complications , Lymphocytes , Pruritus/etiology , Skin Neoplasms/complications
2.
Int J Dermatol ; 62(4): 501-507, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36468846

ABSTRACT

BACKGROUND: We aimed to evaluate if psoriasis associated with restless legs syndrome (RLS) due to its close relationship with metabolic disorders. METHODS: This was a cross-sectional study in which the relationship between RLS and psoriasis was evaluated. Seventy consecutive psoriasis patients and 70 controls without any skin disorder were included in this study. Data including age, gender, body weight, height, and Psoriasis Area Severity Index (PASI) scores were recorded. Diagnosis of RLS was established using International RLS Study Group (IRLSSG) diagnostic criteria. International RLS Rating Scale (IRLSRS) was used to evaluate the severity of symptoms. Each participant completed forms of the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Dermatology Life Quality Index (DLQI). RESULTS: The RLS frequency in patients with psoriasis was 18.6% vs. 5.7% in the control group (P = 0.018). In psoriasis patients, BMI, DLQI, IRLSRS, hemoglobin, ferritin, CRP, and uric acid levels were significantly higher than those of the controls. In psoriasis patients with RLS, PASI, DLQI, PSQI, IRLSRS scores, CRP level, and BMI were significantly higher, and hemoglobin level was significantly lower relative to the psoriasis patients without RLS. PASI score was the sole independent associate of RLS presence in psoriasis patients. CONCLUSION: Restless legs syndrome was significantly more common in psoriasis patients, and the presence of RLS was associated with significantly more severe psoriasis, more severe systemic inflammation, lower serum hemoglobin values, worse quality of life, and sleep quality.


Subject(s)
Psoriasis , Restless Legs Syndrome , Sleep Wake Disorders , Humans , Sleep Quality , Restless Legs Syndrome/complications , Restless Legs Syndrome/epidemiology , Restless Legs Syndrome/diagnosis , Quality of Life , Cross-Sectional Studies , Severity of Illness Index , Psoriasis/complications , Inflammation/complications , Hemoglobins , Sleep , Sleep Wake Disorders/etiology , Sleep Wake Disorders/complications
3.
Postepy Dermatol Alergol ; 39(4): 704-707, 2022 Aug.
Article in English | MEDLINE | ID: mdl-36090713

ABSTRACT

Aim: The aim of the study was to investigate data from patients suffering from chronic spontaneous urticaria refractory to conventional therapy, and to document outcomes of omalizumab use. Material and methods: We conducted a single-centre retrospective study with 175 chronic spontaneous urticaria patients who were treated with 300 mg omalizumab subcutaneously every 4 weeks for at least 6 months. Efficacy, factors affecting outcome, and complications were examined. Results: The complete response rate was 70.9%. Minor complications were observed in 12% of our patients. Anaphylaxis occurred in 1 patient as a major complication. We did not notice any clinical or laboratory factors predicting response to omalizumab treatment. Conclusions: The findings show that omalizumab is effective and safe for the treatment of chronic spontaneous urticaria with a dosing of 300 mg/month subcutaneously. However, due to 1 case of anaphylaxis in this small group, we must still remind practitioners to be alert for this possible complication.

4.
Dermatitis ; 33(6S): S69-S72, 2022.
Article in English | MEDLINE | ID: mdl-35511447

ABSTRACT

BACKGROUND: There are differing results in the literature regarding the relationship between atopic dermatitis (AD) and peripheral blood leukocyte profiles. OBJECTIVE: The aim of the study was to investigate the relationship between AD, blood immune cell profiles, and disease severity. METHODS: One hundred AD patients aged 1 month to 18 years without any history of infection or systemic disease were enrolled as the study group. Serum concentration levels of total immunoglobulin E, calculated blood leukocyte profiles, and AD index severity scoring were calculated for statistical comparison. RESULTS: The differences between the groups for neutrophil-lymphocyte ratio and eosinophil-lymphocyte ratio were statistically different. However, there was no statistically significant correlation between the investigated parameters and AD index severity scoring. CONCLUSIONS: Although significant differences were found in some of the parameters between the groups, unfortunately, the lack of correlation between the parameters investigated and the disease severity index restricts their use in clinical practice.


Subject(s)
Dermatitis, Atopic , Humans , Biomarkers , Leukocyte Count , Eosinophils , Immunoglobulin E , Severity of Illness Index
5.
Postepy Dermatol Alergol ; 37(3): 360-363, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32792876

ABSTRACT

INTRODUCTION: Isotretinoin (13-cis retinoid) is a synthetic retinoid. It was approved by the FDA in 1982 for use of oral isotretinoin in severe acne. It is also used in moderate-severe acne that does not respond to conventional treatments. Isotretinoin is the only available drug that affects all stages of acne pathogenesis. AIM: To prospectively investigate whether there is an effect of isotretinoin therapy on auditory function and, if so, to demonstrate its association with simultaneous blood lipid levels. MATERIAL AND METHODS: Thirty patients (60 ears) with acne vulgaris, who received 0.5 mg/kg of isotretinoin therapy, were included in the study. Distortion product otoacoustic emissions (DPOAEs) and pure tone audiometry tests were performed to evaluate auditory function at the beginning of the procedure and the 6th month of treatment. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol, triglyceride, high-density lipoproteins (HDL) and low-density lipoproteins (LDL) cholesterol levels were recorded. RESULTS: There was no statistically significant difference between pre-treatment and post-treatment mean pure tone audiometry threshold and DPOAE values; however, the increase in total blood cholesterol, triglyceride and LDL levels and the decrease in HDL levels were statistically significant. CONCLUSIONS: According to our study findings, isotretinoin did not cause worsening of the bilateral hearing threshold, but increased blood lipid levels. There is no need for follow-up auditory functions in routine practice during therapy, but blood lipid levels should be monitored.

6.
Am J Ther ; 25(6): e626-e634, 2018.
Article in English | MEDLINE | ID: mdl-26808358

ABSTRACT

Herpes zoster (HZ) is a common disease characterized by the recurrence of varicella zoster, that stays dormant in sensory ganglia. The primary goal of this study was to compare efficiencies of famciclovir, valaciclovir, and brivudine in terms of pain relief in HZ patients. Records of patients who were admitted to the Dermatology Clinic of our hospital due to acute HZ between the years 2012 and 2014 were retrospectively analyzed. Treatment decisions were at the discretion of caring physicians as valaciclovir (VACV), famciclovir (FCV), and brivudine (BRV) based on the clinical observations. BRV, FCV, and VACV were effective in treating pain in acute HZ. There was no significant difference between mild and moderate HZ patients. In severe cases, a significant reduction in intensity of pain was observed on day 3 in the BRV group, on day 7 in the FCV group, and at 2-3 weeks in the VACV group. There were no significant side effects observed in any of the groups. Results of this study indicate that brivudine may be the first choice in severe HZ cases as it controls pain earlier and is easier to use because of its once daily administration.


Subject(s)
Antiviral Agents/therapeutic use , Bromodeoxyuridine/analogs & derivatives , Famciclovir/therapeutic use , Herpes Zoster/drug therapy , Pain/drug therapy , Valacyclovir/therapeutic use , Adult , Aged , Antiviral Agents/administration & dosage , Bromodeoxyuridine/administration & dosage , Bromodeoxyuridine/therapeutic use , Drug Administration Schedule , Famciclovir/administration & dosage , Female , Herpes Zoster/complications , Humans , Male , Middle Aged , Pain/diagnosis , Pain/etiology , Pain Measurement , Retrospective Studies , Severity of Illness Index , Treatment Outcome , Valacyclovir/administration & dosage
7.
J Back Musculoskelet Rehabil ; 31(1): 37-43, 2018 Feb 06.
Article in English | MEDLINE | ID: mdl-28946518

ABSTRACT

BACKGROUND AND OBJECTIVE: Rheumatoid arthritis (RA), insulin-dependent diabetes mellitus (IDDM), inflammatory bowel disease, systemic lupus erythematosus (SLE) and multiple sclerosis (MS) are some of the autoimmune diseases related to the decreases in Vitamin D levels. The same immunological properties as psoriasis, such as Th1/Th2 dysregulation, are seen in all of them. This study aims to compare 25-hidroksi Vitamin D (25-OHD) serum concentrations in patients with psoriasis and psoriatic arthritis. METHODS: This study includes 91 outpatients; 48 of these patients were chosen randomly among the psoriasis (PS) patients from the dermatology department of the researchers' hospital. Forty-three of them were chosen among the psoriatic arthritis (PsA) patients matching the age and gender criteria from the rheumatology department of the researchers' hospital. In this study, 25-OHD serum concentrations among the psoriasis and psoriatic arthritis patients were compared. RESULT: There are more patients in the PsA group with 25-OHD levels lower than 20 ng/ml; however, this finding is insufficient to obtain statistical significance (p= 0.09). PsA and psoriasis groups had similar numbers of patients with 25-OHD levels ranging from 20 to 30 mg/mL and those higher than 30 mg/mL (p> 0.05). CONCLUSION: The literature does not show significant differences between the PS and PsA groups in terms of serum 25-OHD levels and a prevalence of Vitamin D deficiency. Besides, PASI scores were higher in the PS group. CRP values in the PsA group were higher than in the PS group. There was a poor negative correlation between CRP and serum 25-OHD levels in the PsA group. This correlation was not found in the PS group.


Subject(s)
Arthritis, Psoriatic/blood , Psoriasis/blood , Vitamin D/blood , Adult , Biomarkers/blood , Female , Humans , Male , Middle Aged , Vitamin D Deficiency/blood
8.
Angiology ; 68(3): 273, 2017 03.
Article in English | MEDLINE | ID: mdl-28168886

Subject(s)
Inflammation , Psoriasis , Humans
9.
Int J Dermatol ; 56(3): 341-345, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28054375

ABSTRACT

In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non-segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively. Demographic data, scores on the Vitiligo Area Score Index (VASI), clinical features, vitiligo disease activity, repigmentation status, presence of any accompanying autoimmune disease, antinuclear antibody (ANA) titers, serum levels of glucose, thyroid-stimulating hormone (TSH), thyroxine (T4) hormone, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-TG) were recorded. The prevalence of halo nevi was significantly higher (P < 0.001) among children than in other patient groups. The prevalence of leukotrichia was higher in adults with adult-onset disease than in either pediatric patients or adults with childhood-onset disease (P = 0.002). Both anti-TG and anti-TPO levels were significantly higher in adults with adult-onset disease than in pediatric patients and adult patients with childhood-onset disease. The prevalence of autoimmune disease was 22.2%. Anti-TG levels were significantly higher in patients with treatment-related repigmentation than in those without repigmentation. This study shows that clinical features and associations with autoimmune disease may vary according to the age of onset of vitiligo.


Subject(s)
Autoimmune Diseases/epidemiology , Nevus, Halo/epidemiology , Skin Neoplasms/epidemiology , Vitiligo/blood , Vitiligo/epidemiology , Adolescent , Adult , Age of Onset , Aged , Antibodies, Antinuclear/blood , Autoantibodies/blood , Blood Glucose/metabolism , Child , Child, Preschool , Comorbidity , Female , Hair Diseases/epidemiology , Humans , Male , Middle Aged , Prevalence , Retrospective Studies , Severity of Illness Index , Skin Pigmentation , Thyrotropin/blood , Thyroxine/blood , Turkey/epidemiology , Vitiligo/physiopathology , Young Adult
10.
Postepy Dermatol Alergol ; 34(5): 468-470, 2017 Oct.
Article in English | MEDLINE | ID: mdl-29515336

ABSTRACT

INTRODUCTION: There are a few studies showing an increased risk of insulin resistance, metabolic syndrome, and oxidative stress in patients with vitiligo. AIM: To investigate whether systemic inflammation is increased in vitiligo patients in a case-control study design. MATERIAL AND METHODS: Nonsegmental vitiligo patients who had been followed at the outpatient dermatology clinic of a university-affiliated teaching hospital, and healthy controls were enrolled in the study. Patients who were receiving systemic treatments and having a systemic disease such as diabetes mellitus and thyroiditis were excluded. Demographic features were recorded and peripheral blood samples were taken from all participants to study serum whole blood count, creatinine, and C-reactive protein (CRP). RESULTS: Fifty patients with localized vitiligo, 43 patients with generalized vitiligo, and 50 healthy volunteers were enrolled in the study. Neutrophil to lymphocyte ratio and serum CRP levels were significantly higher in patients who have generalized vitiligo than those with localized vitiligo and healthy controls. However, there was no significant difference regarding neutrophil to lymphocyte ratio (NLR) and CRP between localized vitiligo and control groups. CONCLUSIONS: Patients with generalized vitiligo seem to have increased systemic inflammation compared with localized vitiligo and control subjects in our cohort. To the best of our knowledge, this is the first study in the literature showing increased NLR values in generalized vitiligo patients. Further studies with cardiovascular disease markers are required to elicit this association better.

11.
Angiology ; 68(3): 266-270, 2017 Mar.
Article in English | MEDLINE | ID: mdl-27401209

ABSTRACT

Patients with psoriasis have increased systemic inflammation and serum uric acid (SUA) levels compared with the general population. However, the role of SUA in modulating inflammation in these patients is not known. We evaluated the associations of SUA with inflammation and psoriasis severity; 199 patients with psoriasis and 54 healthy volunteers were included in the study. Demographic features, Psoriasis Area and Severity Index (PASI) scores, and laboratory data including SUA, C-reactive protein (CRP), and neutrophil to lymphocyte ratio (NLR) were collected. Patients with psoriasis had higher fasting blood glucose, body mass index (BMI), CRP, SUA, white blood cell (WBC) count, neutrophil count, and NLR compared with controls. The PASI score positively correlated only with CRP ( r = .185, P = .012) and NLR ( r = .313, P < .001). The BMI, WBC count, PASI score, and CRP, but not SUA, appeared as independent associates of NLR in patients with psoriasis in linear regression analysis. Neutrophil to lymphocyte ratio and SUA were significantly increased in patients with psoriasis compared with controls. Neutrophil to lymphocyte ratio and CRP were independent predictors of PASI score, whereas SUA was not. Serum uric acid seemed not to modulate the inflammation seen in patients with psoriasis in our cohort.


Subject(s)
Inflammation Mediators/blood , Inflammation/blood , Psoriasis/blood , Uric Acid/blood , Adult , Biomarkers/blood , Case-Control Studies , Female , Humans , Inflammation/diagnosis , Lymphocyte Count , Lymphocytes , Male , Middle Aged , Neutrophils , Predictive Value of Tests , Psoriasis/diagnosis , Risk Factors , Severity of Illness Index , Up-Regulation
12.
Cutan Ocul Toxicol ; 36(1): 96-97, 2017 Mar.
Article in English | MEDLINE | ID: mdl-26983583

ABSTRACT

There are only a few case reports about nail changes due to valproic acid in the literature despite its widespread use. We present a 50-year-old man who had onycholysis, roughness of the nail surface and brownish-yellow discoloration of both fingernails and toenails, which remarkably ameliorated upon cessation of valproic acid.


Subject(s)
Anticonvulsants/adverse effects , Nails/drug effects , Valproic Acid/adverse effects , Epilepsy/drug therapy , Humans , Male , Middle Aged , Pigmentation/drug effects
14.
J Dermatolog Treat ; 28(1): 82-85, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27151312

ABSTRACT

A few previous case reports related vitamin A and retinoid use with elevated serum uric acid (SUA) levels. Recently, a population based study showed an independent positive correlation of serum retinol with SUA levels. Despite increasing importance of SUA in a number of disease states, no study has examined the association between retinoids and SUA. We aimed to evaluate the effect of pharmacologic dose isotretinoin on SUA level. This was a cohort study in which 51 consecutive adult patients with severe acne vulgaris who were prescribed oral isotretinoin treatment (0.5 mg/kg) were included. Dermatologic examination was performed and SUA levels were measured at study inclusion for each participant, and then repeated at the first and second months of therapy. SUA levels at first month and second month were significantly higher than baseline SUA levels (p: 0.001, 0.007, respectively). SUA levels at second month were higher than SUA levels at first month, but the difference did not reach statistical significance. This study is the first to show that pharmacologic dose oral isotretinoin treatment significantly increased SUA levels. Since hyperuricemia is associated with renal disease, hypertension, atherosclerosis and metabolic syndrome as well as gout, it is important for the dermatologist to be aware of this potential adverse effect of isotretinoin particularly in vulnerable patients.


Subject(s)
Acne Vulgaris/drug therapy , Isotretinoin/therapeutic use , Uric Acid/blood , Administration, Oral , Adolescent , Adult , Cohort Studies , Female , Humans , Male , Young Adult
15.
Oncol Lett ; 12(5): 3475-3477, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27900023

ABSTRACT

The incidence rate of multiple primary tumors is 37% in all types of cancer. A patient diagnosed with primary cancer is 1.29 times more likely to develop an additional primary cancer when compared with the general population. Furthermore, in patients diagnosed with primary cancer, the possibility of a secondary malignancy in the same or different organ is increased. Following the identification of a secondary tumor, the risk of relapse or metastasis must be considered. The present study reports the case of a 76-year-old man who was admitted to Sakarya University Training and Research Hospital (Sakarya, Turkey) with swelling of the head, which had been apparent for 15 days. An excisional biopsy of the temporal region was performed and was used to diagnose the patient with synchronous squamous cell carcinoma with sarcomatoid differentiation of the scalp. The patient was referred to the Department of Plastic Surgery (Sakarya University Training and Research Hospital) for resection; however, he refused treatment and was subsequently discharged. To the best of our knowledge, this patient represents the first case of synchronous skin malignancy and urothelial carcinoma of the bladder to be reported in the literature.

17.
An Bras Dermatol ; 91(5): 655-657, 2016.
Article in English | MEDLINE | ID: mdl-27828644

ABSTRACT

Milia-like idiopathic calcinosis cutis (MICC) is a very rare dermatological disorder characterized by multiple whitish to skin colored, milia-like papules, mostly found on the hands. MICC can disappear spontaneously by adulthood; therefore, its early recognition is crucial to avoiding unnecessary interventions. Herein, we present a case of MICC in a 6-year-old girl with Down syndrome.


Subject(s)
Calcinosis/diagnosis , Down Syndrome/complications , Skin Diseases/diagnosis , Calcinosis/complications , Calcinosis/pathology , Child , Dermoscopy , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Female , Foot Dermatoses/diagnosis , Foot Dermatoses/pathology , Hand Dermatoses/diagnosis , Hand Dermatoses/pathology , Humans , Skin Diseases/pathology
18.
An. bras. dermatol ; 91(5): 655-657, Sept.-Oct. 2016. graf
Article in English | LILACS | ID: biblio-827743

ABSTRACT

Abstract: Milia-like idiopathic calcinosis cutis (MICC) is a very rare dermatological disorder characterized by multiple whitish to skin colored, milia-like papules, mostly found on the hands. MICC can disappear spontaneously by adulthood; therefore, its early recognition is crucial to avoiding unnecessary interventions. Herein, we present a case of MICC in a 6-year-old girl with Down syndrome.


Subject(s)
Female , Child , Skin Diseases/diagnosis , Calcinosis/diagnosis , Down Syndrome/complications , Skin Diseases/pathology , Calcinosis/complications , Calcinosis/pathology , Dermoscopy , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Foot Dermatoses/diagnosis , Foot Dermatoses/pathology , Hand Dermatoses/diagnosis , Hand Dermatoses/pathology
19.
J Cosmet Laser Ther ; 18(8): 428-431, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27351074

ABSTRACT

BACKGROUND AND OBJECTIVES: Superficial cutaneous vascular lesions (SCVLs) are quite common. Several types of lasers have been used to treat these lesions; however, there are no dedicated treatment guidelines and few studies in the literature addressed their treatment. AIMS: In this paper, we aimed to report our clinical experience with potassium titanyl phosphate (KTP) laser treatment on different types of facial SCVLs including telangiectasia, spider angioma, and erythema. METHODS: Data were retrospectively collected from 146 patients with SCVLs, who had been treated with the 532-nm wavelength laser at our outpatient dermatology clinic. Treatment responses were graded as four groups: clearance (> 75% improvement compared with the previous session), marked improvement (50-75%), partial improvement (25-50%), and no response (< 25%). RESULTS: The rate of clearance plus marked improvement (favorable outcome) was 66.1% for telangiectasia group, 93.5% for spider angioma group, and 26.7% for erythema group. Mean number of treatments was 2.9 ± 1.4 for telangiectasia group, 1.4 ± 0.8 for spider angioma group, and 2.9 ± 1.7 for facial erythema group. Only minimal adverse effects related to treatment procedure were detected in 5 out of 146 (3.4%) patients. CONCLUSIONS: Our results demonstrated that KTP laser might be a safe and effective laser modality for SCVLs, which may be associated with physiological problems due to cosmetic concerns.


Subject(s)
Erythema/radiotherapy , Hemangioma/radiotherapy , Lasers, Solid-State/therapeutic use , Low-Level Light Therapy/methods , Telangiectasis/radiotherapy , Adult , Cosmetic Techniques/adverse effects , Cosmetic Techniques/instrumentation , Female , Humans , Lasers, Solid-State/adverse effects , Low-Level Light Therapy/instrumentation , Male , Middle Aged
20.
BMJ Case Rep ; 20162016 Mar 30.
Article in English | MEDLINE | ID: mdl-27030460

ABSTRACT

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, also known as drug-induced hypersensitivity syndrome (DHIS), is an acute, potentially life-threatening disease that includes skin rash, fever, haematological abnormalities and multiorgan involvement. Although its aetiopathogenesis is not exactly known, it is thought that inefficient drug detoxification leading to the accumulation of drug reactive metabolites causes autoimmune responses in skin and some internal organs, alters immune responses and induces reactivation of viral infections in people who have genetic predisposition. To the best of our knowledge, only one case of DRESS syndrome has been reported after delivery of the influenza vaccine, but the drug that induced the reaction in that case was sulfasalazine. We report a case of a 64-year-old woman, receiving allopurinol, who developed DRESS syndrome after taking the influenza vaccine.


Subject(s)
Allopurinol/adverse effects , Drug Hypersensitivity Syndrome/drug therapy , Influenza Vaccines/adverse effects , Drug Hypersensitivity Syndrome/diagnosis , Exanthema/chemically induced , Female , Herpesvirus 6, Human/physiology , Humans , Methylprednisolone/administration & dosage , Methylprednisolone/therapeutic use , Middle Aged , Treatment Outcome , Virus Activation
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