ABSTRACT
Propósito: Analizar los resultados obtenidos en el tratamiento del carcinoma de cuello uterino y su relación con diversos factores clínicos de la casuística. Material y método: Se estudian 187 pacientes afectas de neoplasia cervical uterina que acudieron al Servicio de Oncología Radioterápica del Hospital Universitario de Salamanca entre enero de 1.980 y diciembre de 1.990. El seguimiento de las mismas ha sido de 24 a 156 meses. Resultados: La supervivencia obtenida ha sido del 57.37 por ciento y del 51.04 por ciento a cinco y diez años respectivamente. La supervivencia libre de enfermedad fue del 59.67 por ciento y del 53.62 por ciento. Conclusiones: El estadio evolutivo en el momento del diagnóstico se muestra como un factor pronóstico fundamental. Además, cuando el síntoma inicial fue una hemorragia genital patológica las pacientes portadoras de carcinomas no epidermoides presentan un mejor pronóstico. El resto de factores clínicos estudiados no mostraron influencia estadísticamente significativa (AU)
Subject(s)
Female , Humans , Radiotherapy/adverse effects , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/radiotherapy , Prognosis , Carcinoma/diagnosisABSTRACT
A retrospective study was made of 29 patients with cervical metastasis of an unknown primary tumor. Sixteen patients received local treatment with surgery and radiotherapy (group A) and 13 patients were treated with induction chemotherapy, surgery and radiotherapy (group B). All patients responded. Local recurrence occurred in 21.4% of group A and 20% of group B. The frequency of distant metastases was similar (18.8% vs 15.4%). The mean survival time of 68 months in group A was longer than the 40 months of group B, and the a 2-year survival rate was 81% in group A and 67% in group B. The 5-year survival was better in group B (56% vs 40%). The primary tumor was identified twice as often in the patients who received only local treatment (group A 37.5% and group B 15.4%). Detection of the primary tumor was the only factor that significantly influenced patient survival.
Subject(s)
Carcinoma/secondary , Carcinoma/therapy , Cervical Vertebrae/radiation effects , Cervical Vertebrae/surgery , Spinal Neoplasms/secondary , Spinal Neoplasms/therapy , Adult , Aged , Carcinoma/mortality , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Retrospective Studies , Spinal Neoplasms/mortality , Survival RateABSTRACT
Radiation therapy is the usual treatment for nasopharyngeal carcinoma. However, in recent years the use of neoadyuvant chemotherapy in the treatment of local and regionally advanced carcinoma has been investigated. We report the results of a retrospective study of two treatments used in our center. The study included 68 patients: 34 (group A) who received radiotherapy alone and 34 (group B) who received neoadyuvant chemotherapy before radiotherapy. In group A, 70.6% achieved a complete clinical response: 23.5% relapsed: 5 patients presented distant metastases. Survival rates at 5 and 10 years were 53% and 27% respectively; the disease-free survival was 71.4% at 5 years and 54% at 10 years. In group B, the complete clinical response rate to neoadyuvant chemotherapy was 35.3%, which increased to 73.5% when the treatment was complemented with radiotherapy. The relapse rate was 14.7%; the survival rates at 5 and 10 years were 49.5% and 49%, respectively; and the disease-free survival was 77.2% at 5 and 10 years.
Subject(s)
Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/radiotherapy , Nasopharyngeal Neoplasms/drug therapy , Nasopharyngeal Neoplasms/radiotherapy , Adult , Aged , Aged, 80 and over , Chemotherapy, Adjuvant , Female , Humans , Male , Middle AgedABSTRACT
The authors study the action of ionizing radiations upon some aspects of the humoral and cellular immune responses in cancer patients. Both humoral and cellular responses are altered in patients having malignant neoplasms; the therapeutic irradiation diminishes the phagocytic activity of monocytes and granulocytes, the number of lymphocytes, the formation of E rosettes, and the lymphocytes blastic transformation, and produces some changes in immunoglobulins. However, the irradiation-induced changes are such that radiation therapy does not conditionate negatively the neoplastic process evolution.
