ABSTRACT
Non-alcoholic fatty liver disease, including non-alcoholic steatohepatosis (NSH) and non-alcoholic steatohepatitis (NASH) is considered to be a wide spread disease. Such reasons as metabolic, toxic, infections, alimentary and cryptogenic cause this disease. Pathogenesis of the disease is complex. If the necessary medical preventive measures are absent the disease develops as follows, first steatosis, then steatohepatitis, fibrosis, liver cirrhosis, hepatocarcinoma. The aim of the investigation was to study influence of Metadoxil in patients with NSH and NASH. The conducted investigation have shown high efficiency of the drug at combined treatment of a patient.
Subject(s)
Aging , Fatty Liver/diagnosis , Fatty Liver/drug therapy , Pyridoxine/therapeutic use , Pyrrolidonecarboxylic Acid/therapeutic use , Adult , Aged , Aging/metabolism , Aging/pathology , Drug Combinations , Fatty Liver/metabolism , Fatty Liver/pathology , Humans , Middle Aged , Pyridoxine/administration & dosage , Pyrrolidonecarboxylic Acid/administration & dosage , Treatment OutcomeABSTRACT
109 patients with hemoblastosis (HB) were examined. Average age was 31.8 +/- 1.4 years in group of lymphogranulomatosis patients, and 44 +/- 5.3 years in group of acute leukemia patients. Group of 46 patients with clinical laboratory signs of hepatic lesion was marked out. Since features of portal blood flow (PBF) revealed at dopplerography did not depend on hepatitis aetiology, all patients with chronic hepatitis were analyzed in one group. These patients were examined clinicobiochemically: functional hepatic tests, markers of viral hepatitis B and C, ultrasonic abdominal scanning, PBF dopplerography, puncture biopsy of hepar. All patients had PBF disturbances such as decrease of portal vein blood flow, increase of venous drainage of hepar and spleen. The degree of disturbances intensity increased depending on degree of chronic hepatitis activity (the index of histological activity) and hepatic fibrosis stage. Thus, presence of chronic hepatitis in HB patients regardless of aetiology, is the factor aggravating patients' stage and corrupting PBF. PBF disturbances (decrease of arterial and venous inflow and increase of venous outflow) and development of fibrous changes apparently related with compression of vessels by connective tissue around central veins, inside of lobules and among of hepatic cells. Consequence of it is including anastomosises in blood flow which leads to redistribution of PBF and portal hypertension forming.
Subject(s)
Blood Flow Velocity/physiology , Hepatitis, Chronic/physiopathology , Leukemia/physiopathology , Liver Circulation/physiology , Lymphoma/physiopathology , Portal System/physiopathology , Adult , Follow-Up Studies , Hepatitis, Chronic/complications , Hepatitis, Chronic/diagnosis , Humans , Leukemia/complications , Leukemia/diagnosis , Lymphoma/complications , Lymphoma/diagnosis , Prognosis , Severity of Illness Index , Ultrasonography, Doppler/methodsABSTRACT
AIM: The study of clinical and echocardiographic status of the heart in patients with lymphogranulomatosis (LGM) late after chemoradiotherapy. MATERIAL AND METHODS: 44 patients with IIA-IV stage of LGM exposed to irradiation of lymph nodes and polychemotherapy according to the schemes ACOP, ABVD, COPP, CHOP, CVPP were examined. Echocardiography was carried out on the unit Sigma-44 and Toshiba. RESULTS: Some changes in the heart by type of myocardiodystrophy or endomyocardial fibrosis were found. The latter are characterized by diminution of the left and (or) right ventricles due to apex obliteration, hardening and thickening of the endocardium and subvalvular structures, diastolic dysfunction and pulmonary hypertension. The main and additional signs are distinguished. The reasons of endomyocardial fibrosis are discussed: severity of the disease, frequent exacerbations and, consequently, higher doses of specific chemoradiotherapy. CONCLUSION: It is necessary to employ sparing policy in planning radiotherapy after high loading antracycline antibiotics.
Subject(s)
Antineoplastic Agents/therapeutic use , Heart Ventricles/physiopathology , Hodgkin Disease/physiopathology , Ventricular Function , Adolescent , Adult , Echocardiography, Doppler , Female , Follow-Up Studies , Heart Ventricles/diagnostic imaging , Heart Ventricles/drug effects , Heart Ventricles/radiation effects , Hodgkin Disease/diagnostic imaging , Hodgkin Disease/drug therapy , Hodgkin Disease/radiotherapy , Humans , Male , Middle Aged , Prognosis , Radiotherapy, Adjuvant , Time Factors , Ventricular Function/drug effects , Ventricular Function/radiation effects , Ventricular Remodeling/drug effects , Ventricular Remodeling/radiation effectsABSTRACT
AIM: Investigation of the condition of the liver, gastrointestinal tract, heart in patients at the stage of clinicohematological remission after treatment for hemoblastosis (acute leukemia, Hodgkin's disease, non-Hodgkin's lymphoma). RESULTS: Marked functional-morphological changes were found: endomyocardial fibrosis, cardiopathy, pulmonary hypertension, chronic atrophic gastritis, colon lesions, dysbacteriosis, viral or drug-induced hepatitis. CONCLUSION: The above affections have developed because of the treatment: chemotherapy, radiotherapy, hemotransfusions, antibacterial drugs. They deteriorate life quality and require a special system of rehabilitation measures.
Subject(s)
Hodgkin Disease/complications , Leukemia/complications , Lymphoma, Non-Hodgkin/complications , Multiple Organ Failure/etiology , Acute Disease , Adult , Follow-Up Studies , Hodgkin Disease/rehabilitation , Hodgkin Disease/therapy , Humans , Leukemia/rehabilitation , Leukemia/therapy , Lymphoma, Non-Hodgkin/rehabilitation , Lymphoma, Non-Hodgkin/therapy , Middle Aged , Quality of Life , Time FactorsABSTRACT
The authors provide the data on the clinical picture and methods of diagnosis, conservative treatment of ischemic lesions of the alimentary organs in 152 patients suffering from abdominal atherosclerosis. Present a systematized description of the visceral syndromes of the ischemic genesis which can be used in the clinical practice for diagnosing abdominal atherosclerosis and specification of the site of arterial occlusion of the branches of the abdominal aorta.
Subject(s)
Aortic Diseases/complications , Arteriosclerosis/complications , Ischemia/diagnosis , Viscera/blood supply , Aged , Aged, 80 and over , Aorta, Abdominal , Colitis/diagnosis , Female , Humans , Ischemia/etiology , Male , Middle Aged , Pancreatitis/diagnosis , SyndromeABSTRACT
The clinical picture and results of instrumental and laboratory investigation of 60 patients suffering from atherosclerosis of unpaired branches of the abdominal aorta with the involvement of the digestive system (ischemic abdominal visceropathy) were analyzed. A scheme of combined clinico-instrumental diagnosis of abdominal atherosclerosis to be made in a hospital was developed.