ABSTRACT
BACKGROUND: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity. METHODS: We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. MAIN OUTCOME MEASURES: Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions. RESULTS: Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763 cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32-3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11-2.57, p = 0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43-8.94, p < 0.001) was also observed in positive mothers. CONCLUSION: This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2 have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.
Subject(s)
COVID-19/epidemiology , Fetal Membranes, Premature Rupture/epidemiology , Pregnancy Complications, Infectious/epidemiology , Premature Birth/epidemiology , Adolescent , Adult , Case-Control Studies , Cesarean Section/statistics & numerical data , Female , Gestational Age , Humans , Infant, Extremely Premature , Infant, Newborn , Infant, Premature , Intensive Care Units, Neonatal/statistics & numerical data , Labor, Induced/statistics & numerical data , Logistic Models , Middle Aged , Multivariate Analysis , Odds Ratio , Pregnancy , Prospective Studies , SARS-CoV-2 , Spain/epidemiology , Young AdultABSTRACT
Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.
Subject(s)
Asymptomatic Infections/epidemiology , COVID-19/epidemiology , Pregnancy Complications, Infectious/epidemiology , Adolescent , Adult , COVID-19/diagnosis , Female , Humans , Infant, Newborn , Middle Aged , Multivariate Analysis , Pregnancy , Pregnancy Outcome , Pregnant Women , Prospective Studies , SARS-CoV-2/isolation & purification , Spain/epidemiology , Young AdultABSTRACT
La Pasteurella multocida es una gammaproteobacteria oportunista que produce una zoonosis caracterizada clínicamente por desarrollar cuadros mayoritariamente respiratorios como neumonía y rinitis atrófica, aunque las manifestaciones clínicas pueden derivar de la colonización de tejidos vascularizados y partes blandas de casi cualquier órgano, produciendo hemorragias, dermonecrosis, celulitis, meningitis, abscesos, septicemia, osteomielitis o endocarditis, entre otras. Este microorganismo se transmite a los humanos a través de mordeduras, arañazos o lesiones producidas por animales domésticos (especialmente gatos y perros), pero también salvajes. El diagnóstico es eminentemente clínico, apoyándose también en una anamnesis pormenorizada, y confirmándose mediante el crecimiento bacteriano en medios de cultivo como el agar sangre o el agar chocolate, de las muestras obtenidas de los pacientes afectados por esta rara infección. La antibioterapia con B-lactámicos durante 2 o 3 semanas, es la base terapéutica de este cuadro, aunque existe un alto porcentaje de pacientes con resistencia a los mismos, pudiendo necesitar terapias basadas en otros antibióticos como carbapenem, fluoroquinolonas o tetraciclinas. Las líneas de investigación más actuales están dando una gran importancia a los procedimientos de inmunización en animales domésticos, ya que por una parte son los principales vectores de transmisión y, por otro lado, la vacunación en humanos ha demostrado no ser efectiva, debido a la baja prevalencia de esta enfermedad en las personas expuestas. A continuación, presentamos el caso de una paciente con antecedentes de miomas uterinos y convivencia con gatos domésticos, que sufre un shock séptico por Pasteurella multocida, que tiene como principal foco infeccioso su útero miomatoso.
Pasteurella multocida is an opportunistic gammaproteobacteria which produces a zoonosis characterized clinically by developing majority respiratory pneumonia and atrophic rhinitis, even the clinical manifestations can be derived from the colonization of vascularized tissue and soft tissue of almost any organ, causing bleeding, dermonecrosis, cellulitis, meningitis, abscesses, sepsis, osteomyelitis or endocarditis, among others. This organism is transmitted to humans through bites, scratches or injuries caused by pets (especially cats and dogs), but also animals wild. The diagnosis is clinical, also leaning on a detailed anamnesis, and confirming through the bacterial growth in culture medium such as blood agar or chocolate agar samples from patients affected by this rare infection. With B-lactam antibiotic therapy for 2 or 3 weeks, is therapeutic base, although there is a high percentage of patients with resistance to them, and may need therapies based on other antibiotics as carbapenem, fluoroquinolones or tetracyclines. The lines of research are giving great importance to immunization procedures in domestic animals, since on the one hand are the main vectors of transmission and, on the other hand, vaccination in humans has proven to be not effective, due to the low prevalence of this disease in exposed persons. Then, present the case of a patient with a history of uterine fibroids and coexistence with domestic cats, suffering septic shock by Pasteurella multocida, which has as its main infectious focus your fibroid uterus.
