Do 'his' education and class matter? The changing effect of the husband on women's labour-market transitions in Italy and Britain.

A new stream of sociological and demographic theory emphasizes individualization as the key process in late modernity. As maintained by Hakim (), women also have increasingly become agents of their own biographies, less influenced by the social class and the family. In this study, I intend to contribute to this debate by analysing how, in Italy and Britain, women's movements between employment and housework are linked to their husband's education and class, and how this link has changed across cohorts. Using discrete-time event-history modelling on the BHPS and ILFI, my findings show that in both countries, if the woman's educational and labour-market profile is controlled for, the husband's occupation and education have lost importance. Yet, although based more on 'her' than 'his' profile, divisions along 'classic' lines are still evident and not context-free, and they assume different forms in the two countries with distinctive institutional and cultural settings. In 'liberal' Britain, women's labour-market participation responds more to motherhood and class than to education, while in 'familistic' Italy education seems more important, which suggests the existence of returns over and above strictly human capital/economic ones.

Attitudes Toward Parenthood, Partnership, and Social Rights for Diverse Families: Evidence From a Pilot Study in Five Countries.

Attitudes toward the civil and social citizenship rights of individuals in diverse family forms are underresearched. We use cross-national data from a pilot study among students in Denmark, Spain, Croatia, Italy, and the Netherlands to explore cross-country differences in beliefs about partnership, parenthood, and social rights of same-sex couples vs. heterosexual couples or married vs. cohabiting couples. The results suggest a polarization in students' attitudes between countries that appear more traditional (i.e., Italy and Croatia) and less traditional (Spain and the Netherlands), where the rights of married heterosexual couples are privileged over other family forms more so than in nontraditional countries. Moreover, equality in social rights is generally more widely accepted than equality in civil rights, particularly in relationship to parenthood rights and in more traditional countries. We discuss the implications of these findings and the implications for further research in this underexplored area of attitudinal research.

Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine.

The biological activity of midkine, a cytokine implicated in neuro- and tumourigenesis, is regulated by its binding to glycosaminoglycans (GAGs), such as heparin and chondroitin sulfate (CS). To better understand the molecular recognition of GAG sequences by this growth factor, the interactions between synthetic chondroitin sulfate-like tetrasaccharides and midkine were studied by using different techniques. Firstly, a synthetic approach for the preparation of CS-like oligosaccharides in the sequence GalNAc-GlcA was developed. A fluorescence polarisation competition assay was then employed to analyse the relative binding affinities of the synthetic compounds and revealed that midkine interacted with CS-like tetrasaccharides in the micromolar range. The 3D structure of these tetramers was studied in detail by a combination of NMR spectroscopy experiments and molecular dynamics simulations. Saturation transfer difference (STD) NMR spectroscopy experiments indicate that the CS tetrasaccharides bind to midkine in an extended conformation, with similar saturation effects along the entire sugar chain. These results are compatible with docking studies that suggest an interaction of the tetrasaccharide with midkine in a folded structure. Overall, this study provides valuable information on the interaction between midkine and well-defined, chemically synthesised CS oligosaccharides and these data can be useful for the design of more active compounds that modulate the biological function of this protein.

3D structure of a heparin mimetic analogue of a FGF-1 activator. A NMR and molecular modelling study.

The motional behaviour of heparin oligosaccharides in solution is best described as a top rotor having two perpendicular rotation axes. This prevents an accurate extraction of interprotonic distances by NOESY/ROESY based methods. In this paper, we describe the solution structure of the hexasaccharide 1 calculated from high exactitude distance data obtained from off-resonance ROESY combined with a long MD simulation of 500 ns. In previous studies, we have found that two synthetic hexasaccharides having the sulphate groups directed towards one side of its central plane have an opposite biological activity, while 1 is unable to activate the FGF-1 signalling pathway, the other (2) is even more active than the regular region derived hexasaccharide (3) that mimics the natural active compound, heparin. From the structural analysis it was concluded that 1 has similar three-dimensional characteristics to 2 or 3 and therefore the differences in the activity should be due to the arrangement of the sulphate groups within the hexasaccharidic sequence.