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1.
Eur Radiol ; 24(1): 95-101, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23982288

ABSTRACT

OBJECTIVE: To prospectively evaluate microstructural abnormalities in sacral nerve roots in women affected by chronic pelvic pain associated with endometriosis. METHODS: We enrolled 30 women with an ultrasound diagnosis of endometriosis and moderate-severe chronic pelvic pain; 10 age-matched healthy women comprised the control group. All subjects underwent 3 T magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI); the sacral roots were reconstructed by post-processing the DTI data with dedicated software. Mean fractional anisotropy (FA) values in the S1, S2 and S3 roots were quantified. Analysis of FA values was performed by two radiologists in order to evaluate the interobserver agreement. RESULTS: The sacral nerve roots in healthy subjects were clearly visualised. Most of the patients with endometriosis displayed abnormalities of S1, S2 and S3 bilaterally at tractography, including an irregular and disorganised appearance. FA values in the S1, S2 and S3 roots were significantly lower in patients than in controls (P < 0.0001, <0.05 and <0.02, respectively) for both observers. No significant difference was found between observers. CONCLUSION: DTI with tractography is a non-invasive means of detecting changes in the microarchitecture of the sacral nerve roots. It can qualitatively and quantitatively reveal sacral root abnormalities in patients with endometriosis-associated pain. KEY POINTS: • MRI is increasingly used for endometriosis and chronic pelvic pain (CPP). • Magnetic resonance tractography can demonstrate microarchitectural abnormalities in sacral nerve roots. • Tractography shows altered microstructure of sacral roots affected by endometriosis and CPP. • S1-S3 fractional anisotropy values are lower in endometriosis than in healthy women. • Sacral nerve root alteration may explain the nature of endometriosis-related CPP.


Subject(s)
Chronic Pain/diagnosis , Diffusion Tensor Imaging/methods , Endometriosis/diagnosis , Pelvic Pain/diagnosis , Spinal Nerve Roots/pathology , Adolescent , Adult , Chronic Pain/etiology , Endometriosis/complications , Female , Follow-Up Studies , Humans , Image Processing, Computer-Assisted , Pain Measurement , Pelvic Pain/etiology , Pilot Projects , Prospective Studies , ROC Curve , Reproducibility of Results , Sacrum , Young Adult
2.
J Matern Fetal Neonatal Med ; 27(12): 1213-9, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24102352

ABSTRACT

Congenital heart disease is one of the most frequent prenatal malformation representing an incidence of 5/1000 live births; moreover, it represents the first cause of death in the first year of life. There is a wide range of severity in congenital heart malformations from lesions which require no treatment such as small ventricular septal defects, to lesions which can only be treated with palliative surgery such as hypoplastic left heart syndrome. A good prenatal examination acquires great importance in order to formulate an early diagnosis and improve pregnancy management. Nowadays, echocardiography still represents the gold standard examination for fetal heart disease. However, especially when preliminary ultrasound is inconclusive, fetal MRI is considered as a third-level imaging modality. Preliminary experiences have demonstrated the validity of this reporting a diagnostic accuracy of 79%. Our article aims to outline feasibility of fetal MRI in the anatomic evaluation, the common indication to fetal MRI, its role in the characterization of congenital heart defects, and at last its main limitations.


Subject(s)
Fetal Heart/anatomy & histology , Fetal Heart/pathology , Heart Defects, Congenital/diagnosis , Magnetic Resonance Imaging , Prenatal Diagnosis/methods , Echocardiography , Feasibility Studies , Female , Fetal Heart/abnormalities , Humans , Pregnancy , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Ultrasonography, Prenatal
3.
Eur J Radiol ; 81(6): 1381-7, 2012 Jun.
Article in English | MEDLINE | ID: mdl-21497034

ABSTRACT

INTRODUCTION: Endometriosis represents an important clinical problem in women of reproductive age with high impact on quality of life, work productivity and health care management. The aim of this study is to define the role of 3T magnetom system MRI in the evaluation of endometriosis. MATERIALS AND METHODS: Forty-six women, with transvaginal (TV) ultrasound examination positive for endometriosis, with pelvic pain, or infertile underwent an MR 3.0T examination with the following protocol: T2 weighted FRFSE HR sequences, T2 weighted FRFSE HR CUBE 3D sequences, T1 w FSE sequences, LAVA-flex sequences. Pelvic anatomy, macroscopic endometriosis implants, deep endometriosis implants, fallopian tube involvement, adhesions presence, fluid effusion in Douglas pouch, uterus and kidney pathologies or anomalies associated and sacral nervous routes were considered by two radiologists in consensus. Laparoscopy was considered the gold standard. RESULTS: MRI imaging diagnosed deep endometriosis in 22/46 patients, endometriomas not associated to deep implants in 9/46 patients, 15/46 patients resulted negative for endometriosis, 11 of 22 patients with deep endometriosis reported ovarian endometriosis cyst. We obtained high percentages of sensibility (96.97%), specificity (100.00%), VPP (100.00%), VPN (92.86%). CONCLUSION: Pelvic MRI performed with 3T system guarantees high spatial and contrast resolution, providing accurate information about endometriosis implants, with a good pre-surgery mapping of the lesions involving both bowels and bladder surface and recto-uterine ligaments.


Subject(s)
Endometriosis/pathology , Magnetic Resonance Imaging/methods , Adult , Contrast Media , Dextrans , Feasibility Studies , Female , Humans , Magnetite Nanoparticles , Predictive Value of Tests , Sensitivity and Specificity
4.
Radiol Med ; 116(7): 1134-48, 2011 Oct.
Article in English, Italian | MEDLINE | ID: mdl-21509548

ABSTRACT

PURPOSE: The aim of our study was to investigate the role of fetal magnetic resonance imaging (MRI) as a complement to ultrasound (US) in the evaluation of cleft lip and palate (CLP), whether isolated or in association with syndromic conditions. MATERIALS AND METHODS: We enrolled 24 pregnant women (27 fetuses) (mean gestational age 23.7 weeks) with a level-two US diagnosis of cleft lip (CL) or CLP with or without associated central nervous system (CNS) or facial-bone anomalies. All individuals underwent a fetal MRI examination to study the facial skeleton, CNS and fetal body. For each fetus, the main anatomical facial landmarks and biometric parameters [anteroposterior diameter (APD), biparietal diameter (BPD), inferior facial angle (IFA), frontomaxillary angle (FMA), bi-orbital diameter (BOD), intraorbital diameter (IOD)] were measured. RESULTS: Twenty-five of 27 fetuses had a US diagnosis of CL or CLP. MRI confirmed the diagnosis in 16/25 fetuses and added information about the extent of the cleft and the degree of involvement of the anterior and posterior palate in 8/25 fetuses. MRI ruled out the diagnosis in 1/25 fetuses and identified an alteration of the parameters IFA, FMA and IOD in 6/24 fetuses. CONCLUSIONS: In the study of CLP fetal, MRI is able to define the degree of involvement of the posterior palate and the lateral extent of the cleft with higher diagnostic accuracy than US. Furthermore, MRI provides a complete study of the fetal head and biometric development of the facial bones, thus enabling early detection of potential syndromic conditions.


Subject(s)
Cleft Lip/diagnostic imaging , Cleft Lip/pathology , Cleft Palate/diagnostic imaging , Cleft Palate/pathology , Magnetic Resonance Imaging , Ultrasonography, Prenatal , Adult , Female , Humans , Predictive Value of Tests , Pregnancy , Pregnancy Complications/diagnostic imaging , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Prospective Studies , Sensitivity and Specificity
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