ABSTRACT
New biomarkers of effect of some controlled ambient air pollutants (formaldehyde, carbon monoxide and TSP) were found in two surveys of Moscow residents (apparently healthy and outpatients with allergic diseases) with a help of screening system of biochemical and immunological parameters. Possible mechanisms of the effects, including interference of atmospheric carbon monoxide and sulfur dioxide with corresponding endogenous second messengers, are discussed.
Subject(s)
Biomarkers/analysis , Environmental Illness/epidemiology , Immunity , Particulate Matter/adverse effects , Population Surveillance/methods , Public Health , Urban Population , Adult , Environmental Health , Environmental Illness/diagnosis , Environmental Illness/metabolism , Female , Humans , Incidence , Male , Middle Aged , Moscow/epidemiology , Retrospective Studies , Young AdultABSTRACT
The paper presents the results of investigating the phenotypic polymorphism of a number of biochemical and immunological parameters (the values of oxidative stress, the activity of catalase and glutathione-S-transferase in red blood cells, the serum levels of catecholamines, tumor-necrosis factor-?, and IgG antibody subclasses) in the authors' hygienic studies of genotypic and nongenotypic population samples.
Subject(s)
Health Status Indicators , Hygiene , Oxidative Stress , Polymorphism, Genetic , Biomarkers/blood , Catalase/blood , Catalase/genetics , Catecholamines/blood , Environmental Exposure/analysis , Environmental Exposure/statistics & numerical data , Erythrocytes/enzymology , Genotype , Glutathione Transferase/blood , Glutathione Transferase/genetics , Humans , Moscow , Oxidative Stress/genetics , Phenotype , Tumor Necrosis Factor-alpha/blood , Tumor Necrosis Factor-alpha/geneticsABSTRACT
The experimental study of the biological activity of the modified calcium chloride produced by a Volgograd plant and that of ash-and-slag of the pharmaceuticals resulting after combustion of a pyrolytic mixture of filtration burning could establish various hazards of these substances.
