[Receptive status of the endometrium in patients with benign ovarian tumors before and after organ-preserving operations]. / Retseptivnyi status endometriya pri dobrokachestvennykh opukholyakh yaichnikov do i posle organosokhranyayushchikh operatsii.

Background. Benign ovarian tumors (BOT) occupy the 2nd place in the structure of diseases of the female genital organs. In 20% of women of reproductive age, BOT are associated with infertility. One of the causes of infertility caused by ovarian tumors is morphofunctional inferiority with impaired endometrial receptivity. OBJECTIVE: To reveal the morphological and functional features of the endometrium and the level of receptivity to sex hormones in patients with BOT before and after organ-preserving operations. MATERIAL AND METHODS: The study included 77 patients with epithelial ovarian tumors (EOT) - I group, 52 with mature teratomas (MT) - II group. Before and 6-12 months after laparoscopic cystectomy aspiration biopsy of endometrium was performed in the middle stage of secretory phase. The percentage and degree of maturity of pinopodes were determined, and the level of expression of estrogen (ER) and progesterone (PR) receptors in the glands and stroma of the endometrium was assessed. RESULTS: At the preoperative stage, a decrease in the number of mature pinopodes in patients with EOT was revealed. Normal levels of ER were determined in glands and stroma of endometrium, PR was reduced both in stroma and glands of uterine mucosa. In patients with MT all markers corresponded to those of healthy women. In the postoperative period an increase in the number of developed pinopodes on the apical surface of endometrium in patients of I group was found. The ER level did not differ from control values, PR remained reduced in stroma. In II group a persistent decrease in quantity of mature pinopodes, ER in stroma, PR in glands and stroma of uterine mucosa was recorded. CONCLUSION: The presence of BOT and unintentional intraoperative removal of healthy ovarian tissue lead to indirect disorders of the morphofunctional state and endometrial receptivity.

[Morphofunctional characteristics of microvessels in serous tumors of the ovaries].

High vascularization is noted in serous papillary ovarian tumors of a low malignancy grade, particularly in malignant serous ovarian tumors with low vascularization in benign neoplasms. Pronounced morphological changes in the vascular wall are found mainly in malignant tumors and tumors of a low malignancy grade where primitive blood vessels of a sinusoid type with a thin muscle wall prevail. Types of vascularization in the tumors studied are variable and this correlates with results of color doppler mapping.

Comparative evaluation of blood vessels in serous tumors of the ovaries by color Doppler mapping and morphometry.

Morphometric study of blood vessels in serous tumors of the ovaries was carried out. Vascularization of benign, borderline, and malignant tumors is different, which agrees with the data of color Doppler mapping. Pronounced morphological changes in vascular wall (degenerative changes, sclerosis, and hyalinosis) were detected mainly in borderline and malignant tumors.

[Ovarian and endometrial status in tubal and peritoneal sterility]. / Sostoianie iaichnikov i éndometriia pri trubnom i peritoneal'nom besplodii.

A total of 97 patients with laparoscopically confirmed tubal and peritoneal sterility were examined. Thirty-six patients presented with a normal biphasic menstrual cycle, the rest 61 with the lutein phase insufficiency. Follicular presence and size were examined by ultrasonography, the dominant follicle and endometrium volumes were estimated. Only in 17 of the 97 examinees all the examined parameters were found normal, in the rest deviations from the normal echographic picture were revealed. More marked changes were detected in the patients with the lutein phase insufficiency. The findings evidenced a direct correlation between ultrasonic data and rectal temperature, adhesion process severity and the results of ovarian biopsy specimen histologic examination. The authors recommend ultrasonic examination for the assessment of ovarian function in patients suffering from tubal and peritoneal sterility.

[Ultrasonic examination of the status of the ovaries and endometrium after the treatment of tubal and peritoneal infertility]. / Sostoianie iaichnikov i éndometriia po dannym UZI v protsesse terapii posle likvidatsii trubnogo i peritoneal'nogo besplodiia.

The authors analyze the usefulness of ultrasonic examination for the assessment of ovarian and endometrial status in 84 patients operated on for tubal and peritoneal sterility. After surgery the patients were recommended nootropic agents and cyclic vitamin therapy for 3 months. In cases with concomitant diseases (endometriosis, small pelvis varicose veins) synthetic estrogen-gestagen drugs, anticoagulants, disaggregants were prescribed. If the treatment did not result in pregnancy in 2 months, ovulation stimulants (clostilbegit, choriogonin) were prescribed. Drug therapy had a favorable effect on ovarian and endometrial function. Ultrasonic examination may be recommended for monitoring ovarian and endometrial status.

[Echography in the examination of postmenopausal patients with endometrial pathology]. / Mesto ékhografii v obsledovanii bol'nykh perioda postmenopauzy s patologiei éndometria.

Small pelvic organs were examined in 61 postmenopausal females suspected for having an intrauterine abnormality and 25 females matched for age who had no clinical signs of endometrial abnormalities. The findings were compared with the results of hysteroscopic and histological examinations of their curettage specimens. There was a 85% agreement of echographic and histological findings in the patients with suspected intrauterine abnormalities. The echography of small pelvic organs is a screening tool for the diagnosis of intrauterine diseases in postmenopausal females. When M-mode echography shows high values, hysteroscopy and separate diagnostic curettage are indicated. M-mode echography is a useful method for checking up the endometrial status in postmenopausal females receiving hormonal therapy for proliferative endometrial processes.

[Tissue pO2 and fetal heart activity during induction of labor with oxytocin]. / Tkanevoe pO2 i serdechnaia deiate'lnos't ploda priaktivatsii rodovykh sil oksitotsinom.

A total of 65 women in labor complicated with uterine inertia were investigated for tissue pO2 and cardiac performance of fetuses under the effect of oxytocin. The authors stated that the aggravation of fetal status in drug-induced labors resulted from poorer tissue oxygenation caused by the activation of uterine contractility. In this line, hypoxic changes of the fetus were more pronounced in pregnancies complicated by nephropathy or prolonged pregnancy. Accurate monitoring of the fetal status and the character of induced labor course was found to be mandatory. Before oxytocin induction the fetus should be protected with diazepam.