ABSTRACT
Amino analogues of cholic acid were synthesized by reduction of oximes with combination of titanium(III) chloride and sodium cyanoborohydride.
Subject(s)
Amines/chemical synthesis , Cholates/chemical synthesis , Amines/chemistry , Borohydrides/chemistry , Cholates/chemistry , Hydroxides/chemistry , Oximes/chemistry , Titanium/chemistryABSTRACT
In northern regions of Siberia, chronic stress induced by north geophysical and climate living conditions, under additional impact of social and technological negative factors transform first into prepathologic and then into pathologic states. At these conditions, even in younger people exhaustion of reserve possibilities of body occurs very drastically. Due to cause mentioned above, in northern shift team workers chronic diseases develop in younger age. Properly planning of development of health care system in North conditions and establishing of social economic priorities needs to consider characteristics of physiologic, biochemical immune, mental and social processes of human health development in extreme conditions.
Subject(s)
Health Status , Occupational Diseases/epidemiology , Stress, Psychological/epidemiology , Catchment Area, Health , Climate , Humans , Industry , Russia/epidemiologyABSTRACT
Epidemiological study of endocrine system pathology in north areas of Russia was carried out. Major regional factor in Siberia north areas is higher occurrence of thyroid pathology caused by iodine deficiency in water and food. Prevention of this disease is one of most relevant problems in these areas.
