ABSTRACT
Comparison of the state of 83 patients with histologically confirmed sarcoidosis observed with a 10 year interval revealed remission in 47% of the cases. The main factors having negative effect on prognosis of the disease included extrapulmonary symptoms, the use ofcorticosteroids (at all stages, especially at stage I and in Lofgren syndrome) and antituberculosis drugs, positive TB test. Risk factors of relapses were stage II sarcoidosis, the use of systemic corticosteroids in patients with Lofgren syndrome and antituberculosis drugs, initially low FEV1/FVLC ratio and the number of lymphocytes in peripheral blood.
Subject(s)
Antitubercular Agents/therapeutic use , Glucocorticoids/therapeutic use , Sarcoidosis , Adult , Disease-Free Survival , Female , Humans , Lung/diagnostic imaging , Male , Patient Acuity , Prognosis , Radiography , Recurrence , Respiratory Function Tests/methods , Risk Factors , Russia/epidemiology , Sarcoidosis/diagnosis , Sarcoidosis/epidemiology , Sarcoidosis/physiopathology , Sarcoidosis/therapyABSTRACT
The authors revealed that actual prevalence of various COLD exceeded the registered value 3.3 times. The actual prevalence appeared to be under influence from tobacco smoking habits distribution, effects of industrial dust pollutants, chronic nasopharyngeal infections, respiratory infections, age, and atmospheric pollution.
