[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Topical differences in the fatty streaks and in the lipofibrous and fibrous plaques]. / Vliianie gemodinamiki na prostranstvennuiu organizatsiiu ateroskleroticheskikh porazhenii aorty cheloveka. Topicheskie otlichiia v lipidnykh polosakh, lipofibroznykh i fibroznykh bliashkakh.

By means of light microscopy of whole-mounted membranous preparations and scanning electron microscopy differences of the three-dimensional organization in the fatty streaks, lipo-fibrous and fibrous plaques in proximal, distal and central parts were investigated. It was revealed that the central parts of the atherosclerotic lesions have a more mature character than the proximal and, especially, distal parts of the plaques. This phenomenon is accounted for by a progressive growth of the plaques along blood flow in distal direction due to the changes in hemodynamics.

[The hemodynamic effect on the spatial organization of atherosclerotic lesions in the human aorta. Plaques at the sites of arterial branching]. / Vliianie gemodinamiki na prostranstvennuiu organizatsiiu ateroskleroticheskikh porazhenii aorty chelovka. Bliashki v mestakh vetvleniia arterii.

By means of light microscopy of whole-mounted membranous preparations and scanning electron microscopy differences of the three-dimensional organization in the macroscopically intact and atherosclerotic human aortic intima in the sites of intercostal artery ostium were investigated. It was shown that the process of atherogenesis begins in the lateral areas and later involves the site of the entry. The flow divider does not contain lipids and resembles fibrous cap of the plaque. Such differences in the three-dimensional organization are accounted for by the local hemodynamic properties.