ABSTRACT
Case histories of 510 patients operated on for chronic destructive pulmonary tuberculosis and mycetoma are analyzed, as are the findings of examinations of 56 patients with cavitary forms of lung involvement (mostly cavernous and fibrocavernous tuberculosis), whose resected lung and bronchial specimens were inoculated to detect the fungi. X-Ray and tomographic examinations were carried out according to the routine methods. Blood serum IgG antibodies to aspergillosis antigen were determined in the enzyme immunoassay. The pathologic material (sputum, bronchial lavage water) was studied in tissue cultures and the pathomorphologic findings analyzed. An x-ray symptom of the foamy nuclear (septal) structure of pulmonary shifts was revealed, that represents a sort of a pathologic tissue response in one of bronchopulmonary aspergillosis forms. This condition was confirmed by high (over 1:1600) values of enzyme immunoassay with aspergillosis antigen.
Subject(s)
Aspergillosis , Bronchial Diseases , Lung Diseases, Fungal , Adult , Aspergillosis/complications , Aspergillosis/diagnostic imaging , Bronchial Diseases/complications , Bronchial Diseases/diagnostic imaging , Diagnosis, Differential , Female , Humans , Lung Diseases, Fungal/complications , Lung Diseases, Fungal/diagnostic imaging , Male , Middle Aged , Radiography , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/diagnostic imagingABSTRACT
The severity of intoxication in tuberculous patients with destructive forms was quantified as the number of middle-size molecules. Diagnostic criteria for Candida infection are provided in the range from Candida carriage to invasive candidiasis basing on enzyme immunoassay and bacteriological examinations findings. Candida carriage is shown to be of little relevance to the intoxication progress and severity, whereas mucosal dissemination on the bronchial tree and subsequent development of the mycotic lesion affect intoxication symptoms aggravating tuberculosis course.
Subject(s)
Candidiasis/complications , Carrier State , Tuberculosis, Pulmonary/complications , Adolescent , Adult , Aged , Antibodies, Fungal/analysis , Candida/immunology , Candida/isolation & purification , Humans , Immunoenzyme Techniques , Middle Aged , SyndromeABSTRACT
The basic clinico-diagnostic criteria are given which detect an intercurrent infection caused by opportunistic fungi of the Candida and Aspergillus genus. The antibacterial drugs of nonspecific action used in patients with destructive forms of respiratory tuberculosis promote the growth and reproduction of fungus flora and aggravate the course of the underlying process in the lung tissue. When there is intercurrent mycotic infection, the antifungal therapy produces a clinical effect in patients with combined pathology.
