ABSTRACT
BACKGROUND: Although health is a prerequisite for happiness, the salience of health for maintaining happiness may be diminished for Blacks when compared to Whites, a phenomenon which can be explained by the Black-White mental health paradox and minorities' diminished returns. AIM: To understand if Black and White adult Americans differ in the effects of self-rated health (SRH) on happiness. METHODS: This cross-sectional study used data from the General Social Survey (GSS; 1972-2018), a nationally representative survey in the US. Our analytical sample included 42,201 Black and White adults. The independent variable was SRH. Happiness was the dependent variable. Sociodemographic factors were covariates. Race was the moderator. Logistic regression was used to analyze the data without and with interaction terms between race and SRH. RESULTS: Overall, good SRH was positively associated with happiness, however, there was a significant interaction between race/ethnicity and good SRH on the outcome (i.e. happiness) . This finding suggested that the boosting effect of good SRH on happiness is weaker for Black than White people. CONCLUSION: In the United States, due to a weaker concordance between good health and happiness, Blacks who have poor SRH are more likely to report happiness. At the same time, Whites who are healthy report happiness, however, Blacks who are healthy do not necessarily report happiness. Disjointed link between health and happiness may be due to different racial, ethnic, and cultural perceptions of physical health and happiness as well as salience of physical health as a component of happiness. This may be an adaptive response of Blacks to sociopolitical as well as health-related adversities over centuries as a result of the combination of oppression, injustice, and poverty.
ABSTRACT
Abstract Background and objectives: Developing brain is more vulnerable to environmental risk than is the developed brain. We evaluated the effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus using stereological methods. Methods: Eighteen neonatal male mice were randomly divided into three groups. Group A, inhaled sevoflurane at a concentration of 1.5%; Group B, inhaled sevoflurane at a concentration of 3%; and Group C (control group), inhaled only 100% oxygen. Treatments were applied for 30 min a day for 7 consecutive days. The hippocampal volume, dendrite length, number of neurons, and number of glial cells were evaluated in each group using stereological estimations. Results: We identified a ∼2% reduction in the volume of the hippocampus in Group A compared to Group C. Mean hippocampal volume was ∼11% smaller in Group B than it was in Group C. However, these differences in hippocampal volume between the groups were not statistically significant (p > 0.05 for all). As for the number of neurons, we found significantly fewer neurons in Group A (∼29% less) and Group B (∼43% less) than we did in Group C (p < 0.05 for both). The dendrite length was ∼8% shorter in Group A and ∼11% shorter in Group B than it was in Group C. Conclusions: Repeated exposure to sevoflurane, regardless of the concentration, reduced the volume of the neonatal mouse hippocampus, as well as the number of neurons and dendrite length.
Resumo Justificativa e objetivos: O cérebro em desenvolvimento é mais vulnerável ao risco ambiental do que o cérebro já desenvolvido. Avaliamos os efeitos da exposição repetida a diferentes concentrações de sevoflurano sobre o hipocampo de ratos neonatos com o uso de métodos estereológicos. Métodos: Dezoito ratos neonatos foram divididos aleatoriamente em três grupos. O Grupo A foi submetido à inalação de sevoflurano a uma concentração de 1,5%; o Grupo B foi submetido à inalação de sevoflurano a uma concentração de 3%; o Grupo C (controle) foi submetido à inalação de apenas oxigênio a 100%. Os tratamentos foram aplicados durante 30 minutos por dia, durante sete dias consecutivos. Volume do hipocampo, comprimento do dendrito, número de neurônios e número de células gliais foram avaliados em cada grupo com o uso de estimativas estereológicas. Resultados: Identificamos uma redução de ∼2% no volume do hipocampo no Grupo A em comparação com o Grupo C. O volume médio do hipocampo foi ∼11% menor no Grupo B do que no Grupo C. Entretanto, essas diferenças no volume do hipocampo entre os grupos não foram estatisticamente significativas (p > 0,05 para todos). Quanto ao número de neurônios, encontramos um número significativamente menor de neurônios no Grupo A (∼29% menos) e no Grupo B (∼43% menos) do que no Grupo C (p < 0,05 para ambos). O comprimento do dendrito foi ∼8% menor no Grupo A e ∼1% menor no Grupo B que no Grupo C. Conclusões: A exposição repetida ao sevoflurano, independentemente da concentração, reduziu o volume do hipocampo neonatal de camundongos, bem como o número de neurônios e o comprimento dos dendritos.
Subject(s)
Animals , Male , Anesthetics, Inhalation/administration & dosage , Sevoflurane/administration & dosage , Hippocampus/drug effects , Random Allocation , Dose-Response Relationship, Drug , Animals, Newborn , MiceABSTRACT
BACKGROUND AND OBJECTIVES: Developing brain is more vulnerable to environmental risk than is the developed brain. We evaluated the effects of repeated exposure to different concentrations of sevoflurane on the neonatal mouse hippocampus using stereological methods. METHODS: Eighteen neonatal male mice were randomly divided into three groups. Group A, inhaled sevoflurane at a concentration of 1.5%; Group B, inhaled sevoflurane at a concentration of 3%; and Group C (control group), inhaled only 100% oxygen. Treatments were applied for 30min a day for 7 consecutive days. The hippocampal volume, dendrite length, number of neurons, and number of glial cells were evaluated in each group using stereological estimations. RESULTS: We identified a â¼2% reduction in the volume of the hippocampus in Group A compared to Group C. Mean hippocampal volume was â¼11% smaller in Group B than it was in Group C. However, these differences in hippocampal volume between the groups were not statistically significant (p>0.05 for all). As for the number of neurons, we found significantly fewer neurons in Group A (â¼29% less) and Group B (â¼43% less) than we did in Group C (p<0.05 for both). The dendrite length was â¼8% shorter in Group A and â¼11% shorter in Group B than it was in Group C. CONCLUSIONS: Repeated exposure to sevoflurane, regardless of the concentration, reduced the volume of the neonatal mouse hippocampus, as well as the number of neurons and dendrite length.
