ABSTRACT
1. Meclofenamate caused a dose-dependent increase in renovascular resistance in conscious rabbits. 2. This effect was greatest in inner cortical zones at the highest dose (6 mg/kg) but at the lowest dose (0.75 mg/kg) vascular resistance in the outer cortex was preferentially increased. 3. In contrast, meclofenamate increased cerebral perfusion and the proportion of cardiac output received by the testis. No effect was demonstrated on other organs studied. 4. The results suggest a local vasodilator influence of renal prostaglandins in normal conscious rabbits.
Subject(s)
Kidney/blood supply , Meclofenamic Acid/pharmacology , Vascular Resistance/drug effects , ortho-Aminobenzoates/pharmacology , Animals , Consciousness , Dose-Response Relationship, Drug , Hemodynamics/drug effects , Kidney/drug effects , Male , Prostaglandin Antagonists/pharmacology , Rabbits , Regional Blood Flow/drug effectsABSTRACT
A fluorescent histochemical technique has been applied to study the adrenergic innervation of human superior mesenteric arteries obtained at autopsy. Specific catecholamine fluorescence was demonstrated in the smaller branches of this artery taken from three infants and one child. No specific fluorescence was seen in arteries from three adult subjects.
