1.
Bioorg Med Chem Lett
; 11(17): 2295-300, 2001 Sep 03.
Article
in English
| MEDLINE
| ID: mdl-11527718
ABSTRACT
6-Oxopurine derivatives containing a northern (N) methanocarba modification (i.e., fused cyclopropane and cyclopentane rings in place of the ribose) were synthesized and the adenosine receptor affinity measured. Guanine or hypoxanthine was coupled at the 7-position, or 1,3-dibutylxanthine was coupled at the 9-position. The pseudoribose ring was also substituted at the 5'-position with an N-methyluronamide or with phosphate groups.