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[Effect of hyperoxia on inflammatory processes. Experimental studies]. / Influenza dell'iperossia sui processi infiammatori. Ricerche sperimentali.

Bimonte, D; Sasso, M; Ottavo, R; Somma, A A; Ruta, A.

Arch Sci Med (Torino) ; 139(4): 417-8, 1982.

Article in Italian | MEDLINE | ID: mdl-7168632

Subject(s)

Edema/prevention & control , Hyperbaric Oxygenation , Animals , Carrageenan/pharmacology , Edema/chemically induced , Male , Rats , Rats, Inbred Strains , Time Factors

Derivatives of 5,7,7-trimethyl-6-oxa-3-azabicyclo [3.2.2] nonane with antiarrhythmic, local anesthetic and hypotensive activities. II.

Bondavalli, F; Lanteri, S; Schenone, P; Mariani, E; Ottavo, R; Somma, A A; Alise, G; Marmo, E.

Farmaco Sci ; 36(4): 237-50, 1981 Apr.

Article in English | MEDLINE | ID: mdl-7250358

Subject(s)

Anesthetics, Local/chemical synthesis , Anti-Arrhythmia Agents/chemical synthesis , Antihypertensive Agents/chemical synthesis , Bridged Bicyclo Compounds, Heterocyclic , Bridged Bicyclo Compounds/chemical synthesis , Bridged-Ring Compounds/chemical synthesis , Acetylcholine/antagonists & inhibitors , Animals , Bridged Bicyclo Compounds/pharmacology , Chemical Phenomena , Chemistry , Epinephrine/toxicity , Guinea Pigs , Hemodynamics/drug effects , Mice , Rabbits

Synthesis and pharmacological activity of (bicyclo [2.2.1] hept-2-ylidene)acetic acid amides and 2-(bicyclo [2.2.1] hept-2-ylidene)ethanamines.

Mariani, E; Schenone, P; Bondavalli, F; Longobardi, M; Giordano, L; Alise, G; Somma, A A; Marmo, E.

Farmaco Sci ; 36(4): 283-91, 1981 Apr.

Article in English | MEDLINE | ID: mdl-7250362

Subject(s)

Camphanes/chemical synthesis , Acetylcholine/antagonists & inhibitors , Anesthetics, Local/chemical synthesis , Animals , Antiparkinson Agents/chemical synthesis , Camphanes/pharmacology , Chemical Phenomena , Chemistry , Motor Activity/drug effects

[Experimental cholestasis, behavior of body functions and reactivity to various drugs]. / Colostasi sperimentale, comportamento di funzioni organismiche e reattività a vari farmaci.

Di Mezza, F; Giordano, L; Vacca, C; Ariello, B; Vairo, G; Somma, A A; Falcone, O; Ottavo, R; Russo, G; Rosatti, F; Di Mezza, G.

Minerva Dietol Gastroenterol ; 26(2): 69-74, 1980.

Article in Italian | MEDLINE | ID: mdl-7383390

Subject(s)

Cholestasis/physiopathology , Adenosine Diphosphate/pharmacology , Alfaxalone Alfadolone Mixture/pharmacology , Animals , Bilirubin/blood , Blood Coagulation Disorders/etiology , Blood Platelets/drug effects , Brain/drug effects , Cytochrome P-450 Enzyme System/biosynthesis , L-Lactate Dehydrogenase/blood , Liver/drug effects , Liver/metabolism , Mice , Motor Activity/drug effects , Pentylenetetrazole/pharmacology , Phenobarbital/pharmacology , Rabbits , Rats , Transaminases/blood

[Neuroleptoanalgesia, platelet aggregation and arousing drugs]. / Neuroleptoanalgesia, aggregazione delle piastrine e risveglianti.

Somma, A A; Rossi, F; Brita, G; Scafuro, M A; Vairo, G; Pedone, P.

Arch Sci Med (Torino) ; 135(2): 241-3, 1978.

Article in Italian | MEDLINE | ID: mdl-28712

Subject(s)

Neuroleptanalgesia , Platelet Aggregation/drug effects , Tranquilizing Agents/pharmacology , Adenosine Diphosphate/pharmacology , Animals , Ethanolamines/pharmacology , Female , Hexobendine/pharmacology , Male , Phentolamine/pharmacology , Rabbits , S-Adenosylmethionine/pharmacology , Thrombin/pharmacology , Tiopronin/pharmacology

[Experimental analysis of the antifibrinolytic, antiplasmin and anti-platelet aggregation activity of aprotinin ]. / Analisi sperimentale dell'attività antifibrinolitica, antiplasminica e antiaggregante piastrinica dell'aprotinina.

Imperatore, A; Alfano, C; Somma, A A; Vairo, G; De Felice, D; Pedone, P.

Arch Sci Med (Torino) ; 135(2): 219-32, 1978.

Article in Italian | MEDLINE | ID: mdl-308361

Subject(s)

Aprotinin/pharmacology , Blood/drug effects , Animals , Blood Coagulation/drug effects , Female , Fibrin/biosynthesis , Fibrinogen/metabolism , Fibrinolysis/drug effects , Male , Platelet Aggregation/drug effects , Rabbits

[Narcosis, platelet aggregation and arousing drugs]. / Narcosi, aggregazione delle piastrine e risveglianti.

Vairo, G; Rossi, F; Scafuro, M A; Russo, G; Pedone, P; Somma, A A.

Arch Sci Med (Torino) ; 135(2): 245-8, 1978.

Article in Italian | MEDLINE | ID: mdl-687073

ABSTRACT

During pentobarbital (25 mg/kg i.v. in 2 min), pentothal (15 mg/kg i.v. in 2 min) and ketamine (10 mg/kg i.v. in 2 min) narcosis, rabbits showed reduced platelet reactivity ot the direct aggregating effect of ADP (2 X 10(-5) M) and the indirect effect of thrombin (0.1 U/ml). Certain arousal drugs, specifically those of metabolic type such as SAMe (20 mg/kg i.v. in 2 min) and Thiola (166 mg/kg i.v. in 2 min) and of haemodynamic type such as nicergoline (6.66 mg/kg i.v. in 2 min) and hexobendine (5 mg/kg i.v. in 2 min) administered 31 min after narcosis induction, impede the depression brought on by narcosis on on platelet reactivity.

Subject(s)

Anesthesia , Anesthetics/pharmacology , Platelet Aggregation/drug effects , Adenosine Diphosphate/pharmacology , Animals , Female , Hexobendine/pharmacology , Ketamine/pharmacology , Male , Nicergoline/pharmacology , Phenobarbital/pharmacology , Rabbits , S-Adenosylmethionine/pharmacology , Thiopental/pharmacology , Thrombin/pharmacology , Tiopronin/pharmacology

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