Repeatable Acoustic Vaporization of Coated Perfluorocarbon Bubbles for Micro-Actuation Inspired by Polypodium aureum.

Polypodium aureum, a fern, possesses a specialized spore-releasing mechanism like a catapult induced by the quick expansion of vaporized bubbles. This study introduces lipid-coated perfluorocarbon droplets to enable repeatable vaporization-condensation cycles, inspired by the repeatable vaporization of Polypodium aureum. Lipid-perfluorocarbon droplets have been considered not to exhibit repeatable oscillations due to bubble collapse of the low surface tension of lipid layers. However, a single lipid-dodecafluoropentane droplet with a diameter of 9.17 µm shows expansion-contraction oscillations over 4000 cycles by changing lipid composition and applying a low-power 1.7 MHz ultrasound to induce the partial vaporization of the droplets. The optimal combinations of shell composition, droplet fabrication, and acoustic conditions can minimize the damage on shell structure and promote a quick recovery of damaged shell layers. The highly expanding oscillatory microbubbles provide a new direction for fuel-free micro- or nanobots, as well as biomedical applications of contrast agents and drug delivery.

Numerical investigation of acoustic cavitation and viscoelastic tissue deformation.

Acoustic cavitation and tissue deformation are studied by modifying a level-set method for compressible two-phase flows to consider viscoelastic tissue deformation. The numerical simulations performed using different shear moduli and bubble-tissue distances demonstrate various interactions between bubble and viscoelastic tissue, including inverted cone-shape bubbles, bubble migration, liquid jet formation, compressive and expansive tissue deformation, and tissue perforation. The bubble is observed to grow larger with increasing tissue bulk modulus and density. The maximum tissue deformation generally increases with decreasing initial bubble-tissue distance and with increasing tissue bulk modulus and density. The tissue shear modulus conditions that maximize tissue deformation are in the range of 1-10 MPa, unless the tissue density is very large.

Numerical investigation of ultrasound focusing and bubble collapse.

Ultrasound focusing and microbubble collapse are numerically investigated using a level-set interface tracking method for two-phase flows with multiple interfaces. The computations for ultrasound propagating through a spherical lens demonstrate the ultrasound refraction and pressure intensification at the rear of the lens. The focusing of the initial negative pressure wave through the lens induces a converging flow and the focusing of the subsequent positive pressure wave further intensifies the pressure at the lens. Computations are extended to bubble oscillations near the focusing lens and compared with the no-lens case. The lens not only amplifies the bubble expansion and contraction rates significantly but also generates a larger pressure gradient across the bubble. This ultrasound focusing effect contributes to the asymmetric collapse of the bubble and the formation of a liquid jet that penetrates the bubble. The effects of lens size, initial bubble radius and bubble-lens distance on bubble expansion and liquid jet are further investigated.

Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field.

Two-microbubble collapse near a spherical cell in an ultrasonic field is numerically analyzed by extending a level-set method for compressible multiphase flows with bubble and cell multiple interfaces. Computations performed with different bubble-bubble distances and size ratios demonstrate various bubble-bubble interactions, such as bubble coalescence, bubble repulsion and attraction, jet penetration into the bubble, and jet collision. The interactions between collapsing bubbles are found to produce strong liquid jet formation and result in significant cell deformation compared to single-bubble collapse. The optimal bubble-bubble distance and size ratio for cell deformation are presented via contour maps based on extensive computations. The influences of the ultrasonic amplitude and frequency on cell deformation are further investigated.

Numerical modelling of acoustic cavitation threshold in water with non-condensable bubble nuclei.

Numerical modelling of acoustic cavitation threshold in water is presented taking into account non-condensable bubble nuclei, which are composed of water vapor and non-condensable air. The cavitation bubble growth and collapse dynamics are modeled by solving the Rayleigh-Plesset or Keller-Miksis equation, which is combined with the energy equations for both the bubble and liquid domains, and directly evaluating the phase-change rate from the liquid and bubble side temperature gradients. The present work focuses on elucidating acoustic cavitation in water with a wide range of cavitation thresholds (0.02-30 MPa) reported in the literature. Computations for different nucleus sizes and acoustic frequencies are performed to investigate their effects on bubble growth and cavitation threshold. The numerical predictions are observed to be comparable to the experimental data in the previous works and show that the cavitation threshold in water has a wide range depending on the bubble nucleus size.

Numerical study of the effect of liquid compressibility on acoustic droplet vaporization.

In acoustic droplet vaporization (ADV), a cavitated bubble grows and collapses depending on the pressure amplitude of the acoustic pulse. During the bubble collapse, the surrounding liquid is compressed to high pressure, and liquid compressibility can have a significant impact on bubble behavior and ADV threshold. In this work, a one-dimensional numerical model considering liquid compressibility is presented for ADV of a volatile microdroplet, extending our previous Rayleigh-Plesset based model [Ultrason. Chem. 71 (2021) 105361]. The numerical results for bubble motion and liquid energy change in ADV show that the liquid compressibility highly inhibits bubble growth during bubble collapse and rebound, especially under high acoustic frequency conditions. The liquid compressibility effect on the ADV threshold is quantified with varying acoustic frequencies and amplitudes.

Numerical investigation of acoustic vaporization threshold of microdroplets.

A numerical model is presented for the acoustic vaporization threshold of a dodecafluoropentane (or perfluoropentane) microdroplet. The model is based on the Rayleigh-Plesset equation and is improved by properly treating the supercritical state that occurs when a bubble collapses rapidly and by employing the van der Waals equation of state to consider the supercritical state. The present computations demonstrate that the microdroplet vaporization behavior depends intricately on bubble compressibility, liquid inertia and phase-change heat transfer under acoustic excitation conditions. We present acoustic pressure-frequency diagrams for bubble growth regimes and the ADV threshold conditions. The effects of acoustic parameters, fluid properties and the droplet radius on the ADV threshold are investigated.