ABSTRACT
A thiophene-derived Schiff base ligand (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine was used for the synthesis of M(II) complexes, [TEM(M)X2] (M = Co, Cu, Zn; X = Cl; M = Cd, X = Br). Structural characterization of the synthesized complexes revealed distorted tetrahedral geometry around the M(II) center. In vitro investigation of the synthesized ligand and its M(II) complexes showed considerable anti-urease and leishmanicidal potential. The synthesized complexes also exhibited a significant inhibitory effect on urease, with IC50 values in the range of 3.50-8.05 µM. In addition, the docking results were consistent with the experimental results. A preliminary study of human colorectal cancer (HCT), hepatic cancer (HepG2), and breast cancer (MCF-7) cell lines showed marked anticancer activities of these complexes.
Subject(s)
Antineoplastic Agents , Coordination Complexes , Molecular Docking Simulation , Schiff Bases , Thiophenes , Urease , Humans , Coordination Complexes/pharmacology , Coordination Complexes/chemistry , Coordination Complexes/chemical synthesis , Antineoplastic Agents/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/chemical synthesis , Urease/antagonists & inhibitors , Urease/metabolism , Thiophenes/chemistry , Thiophenes/pharmacology , Thiophenes/chemical synthesis , Schiff Bases/chemistry , Schiff Bases/pharmacology , Schiff Bases/chemical synthesis , Morpholines/chemistry , Morpholines/pharmacology , Morpholines/chemical synthesis , Cell Line, Tumor , Enzyme Inhibitors/pharmacology , Enzyme Inhibitors/chemistry , Enzyme Inhibitors/chemical synthesis , Molecular Structure , Leishmania/drug effects , Structure-Activity Relationship , Antiprotozoal Agents/pharmacology , Antiprotozoal Agents/chemistry , Antiprotozoal Agents/chemical synthesis , Drug Screening Assays, AntitumorABSTRACT
Green fuel from water splitting is hardcore for future generations, and the limited source of fresh water (<1%) is a bottleneck. Seawater cannot be used directly as a feedstock in current electrolyzer techniques. Until now single atom catalysts were reported by many synthetic strategies using notorious chemicals and harsh conditions. A cobalt single-atom (CoSA) intruding cobalt oxide ultrasmall nanoparticle (Co3 O4 USNP)-intercalated porous carbon (PC) (CoSA-Co3 O4 @PC) electrocatalyst was synthesized from the waste orange peel as a single feedstock (solvent/template). The extended X-ray absorption fine structure spectroscopy (EXAFS) and theoretical fitting reveal a clear picture of the coordination environment of the CoSA sites (CoSA-Co3 O4 and CoSA-N4 in PC). To impede the direct seawater corrosion and chlorine evolution the seawater has been desalinated (Dseawater) with minimal cost and the obtained PC is used as an adsorbent in this process. CoSA-Co3 O4 @PC shows high oxygen evolution reaction (OER) activity in transitional metal impurity-free (TMIF) 1 M KOH and alkaline Dseawater. CoSA-Co3 O4 @PC exhibits mass activity that is 15 times higher than the commercial RuO2 . Theoretical interpretations suggest that the optimized CoSA sites in Co3 O4 USNPs reduce the energy barrier for alkaline water dissociation and simultaneously trigger an excellent OER followed by an adsorbate evolution mechanism (AEM).
ABSTRACT
Invited for the cover of this issue are Purnaâ Chandraâ Rao, Minyoungâ Yoon and co-workers at Kyungpook National University, Gachon University, POSTECH, Korea Atomic Energy Research Institute and the University of Sydney. The image depicts how single C8 isomers are selectively isolated from a mixture. Read the full text of the article at 10.1002/chem.202102640.
ABSTRACT
Correction for 'Organic guest molecule induced ultrafast breathing of an epitaxially grown metal-organic framework on a self-assembled monolayer' by Purna Chandra Rao et al., Chem. Commun., 2021, DOI: 10.1039/d1cc03721h.
ABSTRACT
We report epitaxially grown new two-dimensional metal-organic framework (MOF) thin films on a self-assembled monolayer (SAM). We fabricated these epitaxial thin-films using stepwise layer-by-layer seeding followed by solvothermal treatment. The MOF thin films exhibit ultrafast structural flexibility (through breathing) compared to their bulk samples upon uptake of organic guest molecules.
ABSTRACT
The breathing phenomenon in metal-organic frameworks (MOFs) has revealed supramolecular host-guest interactions that could be beneficial for chemical separation in numerous industrial applications. The cost-effective purification of C8 alkyl aromatics such as o-xylene, m-xylene, p-xylene, and ethylbenzene remains challenging owing to their similar molecular structures, boiling points, kinetic diameters, polarities, etc. Herein, we report two Zn-based pillar-bilayered MOFs, denoted [Zn2 (aip)2 (pillar)] (aip=5-aminoisophthalic acid; pillar: bpy=4,4'-bipyridine or bpe=1,2-bis(4-pyridyl)ethane) that exhibit a breathing effect depending on the adsorbed guest molecules. Guest-dependent sorption studies in organic solvents such as N,N-dimethylformamide, methanol, benzene, and water vapor display reversible structural flexibility through the breathing effect in both framework compounds. The experiments conducted on C8 -alkyl aromatics resulting in both MOF compounds can access these isomers in the shrunken pores, and thereby expand the pore size by framework breathing. In C8 binary mixtures, these Zn-MOFs exhibit selective sorption properties based on the different interactions between guest C8 aromatics and the framework structure.
