Quality of Life, Satisfaction, Occlusal Force, and Halitosis after Direct and Indirect Relining of Inferior Complete Dentures.

OBJECTIVE: The aim of this study was to compare the direct relining technique with the indirect relining technique in relation to quality of life, satisfaction with the relining, occlusal force, and halitosis of users of acrylic complete dentures. MATERIALS AND METHODS: Twenty bimaxillary edentulous individuals were selected. They had to use the same pair of complete dentures for a minimum of 1 year and a maximum of 5 years. The subjects were randomly divided in groups of direct relining and indirect relining of the inferior denture (n = 10). Both groups received the same silicone-based relining. The clinical tests verified the quality of life (Oral Health Impact Profile in edentulous individuals), the satisfaction with the relining, the occlusal force, and halitosis. The tests (halitosis and occlusal force) were performed initially (before the relining), immediately after the relining, and 30, 60, 90, and 180 days after the relining. The questionnaires (quality of life and satisfaction with the relining) were performed initially (before the relining), and 30, 60, 90, and 180 days after the relining. STATISTICAL ANALYSIS: Analysis of variance and the Tukey test were used (p < 0.05). RESULTS: There was no statistical difference comparing the two techniques in all the evaluations (p < 0.05). There was a significant statistical difference for the factor of time in all clinical tests for each relining technique (p < 0.05). The quality of life and satisfaction with the relining increased significantly 30 days after the relining when compared with the initial time point, for both techniques (p < 0.05). The occlusal force increased significantly after 90 and 180 days when compared with the initial time point, for both techniques (p < 0.05). Halitosis decreased significantly immediately after the relining when compared with the initial time point, for both techniques (p < 0.05). CONCLUSION: Independent of the relining technique used, there was an increase in the quality of life, satisfaction with the relining, and occlusal force, as well as a reduction in the level of halitosis. Both techniques generated similar results and therefore can be options in clinical practice.

Influence of thermocycling and disinfection on the color stability and hardness of thermoplastic sheets used for occlusal splint fabrication.

The aim of this study was to compare PETG/TPU (polyethylene terephthalate glycol/thermoplastic polyurethane) with PETG (polyethylene terephthalate glycol), based on color stability and microhardness. Sixty circular specimens (10 mm in diameter × 3 mm thick) were fabricated (30 PETG/TPU and 30 PETG). The specimens in both groups were submitted to 2000 thermal cycles in alternating baths of 60 seconds at 5°C ± 1°C and 55°C ± 1°C. The specimens were then divided into subgroups (n = 10) that were disinfected 15 minutes per day for 60 days in 1 of 3 solutions: liquid soap, 2% chlorhexidine, or Listerine. Color change (∆E*) and Knoop microhardness tests were performed at baseline (T0), after thermocycling (T1), and after disinfection (T2). Analysis of variance (ANOVA) and Tukey test were used (P < 0.05). ANOVA showed that there was no statistically significant difference in color change between the 2 materials after thermocycling (∆E*1) or after disinfection (∆E*2), regardless of the disinfectant. Intragroup comparisons (Listerine, liquid soap, and 2% chlorhexidine) of the 3 PETG/TPU groups or 3 PETG groups after disinfection revealed no statistically significant difference for microhardness. Comparison of PETG/TPU with PETG based on the overall mean microhardness showed that the PETG/TPU had a significantly greater mean surface hardness value (P < 0.05). The Tukey test revealed statistically significant increases in microhardness at T1 and T2 for PETG/TPU and PETG so that T0 < T1 < T2 (P < 0.05). Both thermoplastic materials demonstrated an increase in hardness after thermocycling and after disinfection, and both showed similar color changes regardless of the disinfection method. Based on the color evaluation, the liquid soap proved to be the best option for disinfection of PETG/TPU and PETG, because the color change (∆E* value) was clinically acceptable for both materials.

Anhedonic- and anxiogenic-like behaviors and neurochemical alterations are abolished by a single administration of a selenium-containing compound in chronically stressed mice.

Despite the severity and the high prevalence of depression and anxiety and the efforts that have been done to improve their treatment, the available pharmacotherapy still has several limitations. Therefore, the investigation of novel agents and the characterization of the molecular signaling pathways underlying their effects are needed. The organoselenium compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole (CMI) has emerged as a promising antidepressant and anxiolytic molecule in several animal models of depression through the modulation of neuroinflammation and oxidative stress. In light of this, the present study aimed to dive into the mechanism of action of CMI in ameliorating anhedonic- and anxiogenic-like behaviors induced by repeated corticosterone administration in mice. A single administration of CMI (1 â€‹mg/kg, i.g.) abrogated the behavioral alterations induced by corticosterone in the open field test, splash test, and elevated plus maze test. Additionally, CMI treatment decreased the levels of reactive species and lipid peroxidation in the plasma of corticosterone-treated mice and normalized the expression of GR, BDNF, synaptophysin, GSK-3ß, Nrf 2 , and IDO in the hippocampi of stressed mice. Noteworthy, the pre-treatment of mice with LY294002 (PI3K inhibitor) and rapamycin (mTOR inhibitor) abrogated the anti-anhedonic- and anxiolytic-like effects elicited by CMI in corticosterone-treated mice, while ZnPP (HO-1 inhibitor) counteracted the anxiolytic-like effect of CMI. These findings suggest that CMI might ameliorate behavioral and biochemical alterations in the depression-anxiety comorbidity induced by corticosterone, highlighting the potential of CMI as a possible adjuvant therapy.

Analysis of physical properties of facial silicones with different pigmentations submitted to nonthermal plasma treatment and accelerated aging.

STATEMENT OF PROBLEM: Exposure of silicone prostheses to environmental factors can alter their properties, affecting longevity. However, whether nonthermal plasma (NTP) can prevent these alterations is unclear. PURPOSE: The purpose of this in vitro study was to evaluate the surface roughness (Ra), sorption, solubility, and color stability (ΔE00) of the MDX4-4210 and A-120 silicones, with and without NTP treatment in accordance with an independent analysis of the use of 2 pigmentations. MATERIAL AND METHODS: One hundred sixty specimens were fabricated and distributed into 16 groups (n=10) as per the silicone, pigmentation, and NTP coating. The NTP was applied, and the Ra, sorption, solubility, and ΔE00 were evaluated before and after accelerated aging. ANOVA was used, and the HSD Tukey test was applied (α=.05). RESULTS: NTP generated an increase in roughness after aging, regardless of pigmentation or silicone. A-120 silicone without NTP showed a reduction in roughness after aging, regardless of pigmentation. For sorption and solubility, the bronze pigmentation (for A-120 and MDX4-4210) presented the smallest results after NTP treatment. For MDX4-4210 with pink pigmentation and NTP, sorption decreased and solubility increased. For A-120 with pink pigmentation and NTP, sorption and solubility increased. Sorption was reduced in all situations, except for A-120 with pink pigmentation, which increased. Regardless of the silicone used, solubility was reduced after NTP for bronze pigmentation. For A-120 and MDX4-4210 with pink pigmentation and NTP, the solubility increased. For both pigmentations, the NTP treatment promoted lower color alteration only for the A-120 silicone after accelerated aging (within the acceptability threshold). CONCLUSIONS: The NTP protocol of this study, which was applied to facial silicones, generated inconsistent results between the evaluated properties. Therefore, the NTP protocol used does not seem to be ideal for the treatment of silicone surfaces after aging.

Synthesis and biological evaluation of new antioxidant and antiproliferative chalcogenobiotin derivatives for bladder carcinoma treatment.

Approximately 90% of bladder carcinomas are of the urothelial carcinoma type, which are characterized by high rates of recurrence and predisposition to progress to invasive tumors, representing one of the most costly neoplasms for health systems. Intravesical chemotherapy is a standard for the treatment of non-invasive bladder cancer. However, chemotherapy is usually aggressive and cytotoxic, which increases the death rates caused by cancer. Heterocyclic compounds which exhibit favorable pharmacokinetic and pharmacodynamic properties may enhance drug affinity for a target protein by targeting the treatment. Thus, this work presents the synthesis, characterization, and in vitro biological evaluation of new antioxidant (inhibition of lipid peroxidation, scavenging of free radical DPPH, and thiol peroxidase-like activity) and antiproliferative chalcogenobiotin derivatives and tests them against bladder carcinoma 5637 cells. A prominent response was obtained for the selected compounds, with tellurium biotin derivatives displaying effective antioxidant and antiproliferative activity. The effective compounds also demonstrated no toxicity in in vitro or in vivo studies.

Synthesis, Molecular Docking, and Preliminary Evaluation of 2-(1,2,3-Triazoyl)benzaldehydes As Multifunctional Agents for the Treatment of Alzheimer's Disease.

We described here our results on the use of thiourea as a ligand in the copper catalysed azide-alkyne cycloaddition (CuAAC) of 2-azidobenzaldehyde with alkynes. Reactions were performed reacting 2-azidobenzaldehyde with a range of terminal alkynes using 10 mol % of copper iodide as a catalyst, 20 mol % of thiourea as a ligand, triethylamine as base, DMSO as solvent at 100 °C under nitrogen atmosphere. The corresponding 2-(1H-1,2,3-triazoyl)-benzaldehydes (2-TBH) were obtained in moderated to excellent yields and according our experiments, the use of thiourea decreases the formation of side products. The obtained compounds were screened for their binding affinity with multiple therapeutic targets of AD by molecular docking: ß-secretase (BACE), glycogen synthase kinase (GSK-3ß) and acetylcholinesterase (AChE). The three compounds with highest affinity, 5 a (2-(4-phenyl-1H-1,2,3-triazol-1-yl)benzaldehyde), 5 b (2-(4-(p-tolyl)-1H-1,2,3-triazol-1-yl)benzaldehyde), and 5 d (2-(4-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-1-yl)benzaldehyde) were selected and evaluated on its antioxidant effect, in view of select the most promising one to perform the in vivo validation. Due the antioxidant potential ally to the affinity with BACE, GSK-3ß and AChE, compound 5 b was evaluated in a mouse model of AD induced by intracerebroventricular injection of streptozotocin (STZ). Our results indicate that 5 b (1 mg/kg) treatment during 20 days is able to reverse the cognitive and memory impairment induced by STZ trough the modulation of AChE activity, amyloid cascade and GSK-3ß expression.

7-Chloroquinoline-1,2,3-triazoyl carboxamides induce cell cycle arrest and apoptosis in human bladder carcinoma cells.

In the present study, the antitumoral properties of a series of 7-chloroquinoline-1,2,3-triazoyl-carboxamides (QTCA) were investigated by analyzing their cytotoxic activities against human bladder cells (5637; grade II carcinoma). In addition, their effects on cell viability, cell cycle arrest mechanisms, apoptosis induction, in silico molecular docking, and detection of pro-apoptotic and anti-apoptotic proteins were evaluated. The cytotoxicity assay identified major dose- and time-dependent cytotoxic effects in 5637 cells after they were exposed to treatment with QTCA, only minimal effects were observed on normal cells. A live/dead assay confirmed that significant cell death, arrest in the G0/G1 phase and apoptosis were associated with treatment by 1-(7-Chloroquinolin-4-yl)-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide (QTCA-1) and 1-(7-Chloroquinolin-4-yl)-N-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide (QTCA-4). The in silico results indicated that these compounds acted through different mechanisms for the induction of cell cycle arrest and apoptosis. Western blotting confirmed the binding of the QTCAs to pro- and anti-apoptotic proteins. In conclusion, QTCA-1 and QTCA-4 are promising candidates for inducing cytotoxicity, cell cycle arrest, and apoptosis in human bladder cancer cells.

Lapatinib-Loaded Nanocapsules Enhances Antitumoral Effect in Human Bladder Cancer Cell.

Transitional cell carcinoma (TCC) represents the most frequent type of bladder cancer. Recently, studies have focused on molecular tumor classifications in order to diagnose tumor subtypes and predict future clinical behavior. Increased expression of HER1 and HER2 receptors in TTC is related to advanced stage tumors. Lapatinib is an important alternative to treat tumors that presents this phenotype due to its ability to inhibit tyrosine kinase residues associated with HER1 and HER2 receptors. This study evaluated the cytotoxicity induced by LAP-loaded nanocapsules (NC-LAP) compared to LAP in HER-positive bladder cancer cell. The cytotoxicity induced by NC-LAP was evaluated through flow cytometry, clonogenic assay and RT-PCR. NC-LAP at 5 µM reduced the cell viability and was able to induce G0/G1 cell cycle arrest with up-regulation of p21. Moreover, NC-LAP treatment presented significantly higher apoptotic rates than untreated cells and cells incubated with drug-unloaded nanocapsules (NC) and an increase in Bax/Bcl-2 ratio was observed in T24 cell line. Furthermore, clonogenic assay demonstrated that NC-LAP treatment eliminated almost all cells with clonogenic capacity. In conclusion, NC-LAP demonstrate antitumoral effect in HER-positive bladder cells by inducing cell cycle arrest and apoptosis exhibiting better effects compared to the non-encapsulated lapatinib. Our work suggests that the LAP loaded in nanoformulations could be a promising approach to treat tumors that presents EGFR overexpression phenotype.

Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.

In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1,2-a] pyridine (MPI; 1, 10 or 50 mg/kg, i.g.) on the acute restraint stress (ARS)-induced depressive- and anxiety-like behaviors in mice and its underlying mechanism of action. We used the open filed test, forced swimming test, and splash test to evaluate depressive-like behavior, and marble burying and elevated plus maze test to measure anxiety-like behavior. We found that MPI attenuated ARS-induced depressive- and anxiety-like behaviors in all behavioral tests, without having an effect in non-stressed mice. MPI prevented the increased in pro-inflammatory cytokines, indoleamine-2,3-dioxygenase (IDO) and inducible nitric oxide synthase (iNOS) expression in brain structures via canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) down-regulation. Additionally, MPI prevented ARS-induced downregulation of brain-derived neurotrophic factor (BDNF), increased reactive oxygen/nitrogen species generation and lipid peroxidation in prefrontal cortex and hippocampus of mice. In addition, MPI blocked the downregulation of glucocorticoid receptors in the prefrontal cortex and hippocampus and reduced the increased circulating level of corticosterone in stressed mice. These results suggested that MPI showed antidepressant- and anxiolytic-like properties and the effects might be associated with the biological changes in the prefrontal cortex and hippocampus.

The selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole reverses depressive-like behavior induced by acute restraint stress in mice: modulation of oxido-nitrosative stress and inflammatory pathway.

RATIONALE AND OBJECTIVES: Stress-induced alterations in oxidative and inflammatory parameters have been implicated in the pathophysiology of mood disorders. Based on the antioxidant and anti-inflammatory properties of the selenium-containing compound 3-((4-chlorophenyl)selanyl)-1-methyl-1H-indole (CMI), we assessed its ability to reverse depression-like behavioral alterations, neuroinflammation, and oxidative imbalance induced by acute restraint stress. METHODS: Mice submitted to restraint for 240 min received CMI (1 or 10 mg/kg, orally) 10 min after the end of the stress induction. Behavioral and biochemical tests were carried out after further 30 min. RESULTS: Restraint-induced depression-like behavior in the tail suspension test (TST), splash test, and new object exploration test was reversed by CMI. None of the treatments evoked locomotor alteration. In addition, CMI abrogated restraint-induced increases in plasma levels of corticosterone and in markers of oxidative stress and impaired superoxide dismutase and catalase activity in the prefrontal cortex (PFC) and hippocampus (HC). CMI also blocked stress-induced downregulation of mRNA levels of glucocorticoid receptor and brain-derived neurotrophic factor and upregulation of nuclear factor kappa B, inducible nitric oxide synthase, tumor necrosis alpha, indoelamine-2,3-dioxygenase, and glycogen synthase kinase 3 beta in PFC and HC. CONCLUSIONS: These preclinical results indicate that administration of selenium-containing compounds might help to treat depression associated with inflammation and oxidative stress. Graphical abstract ᅟ.

Assessment of Salivary Flow and Anxiety in Patients Rehabilitated with Implant-Supported Prostheses.

BACKGROUND: The aim of this study was to verify, through self-assessment questionnaires, the influence of implant-supported prosthesis in salivary flow and anxiety of patients rehabilitated with them. MATERIALS AND METHODS: Visual analog scale (VAS) questionnaire about xerostomia and State-Trait Anxiety Inventory were applied before (T1) and after 2 days (T2) and 3 weeks (T3) of prostheses installation. The study included patients rehabilitated with implant-supported prostheses containing three or more dental elements. A total of 17 patients were evaluated. RESULTS: In VAS questionnaire, there was a significant increase in the difficulty of speaking and swallowing with dry mouth. The other VAS questions showed no statistically significant difference, indicating no changes in patients' salivary flow. CONCLUSIONS: It was concluded that the installation of implant-supported prostheses does not lead to major changes in patients' perception about their salivary flow and psychological state, causing no improvement or worsening in the characteristics evaluated.

Tear Strength Analysis of MDX4-4210 and A-2186 Silicones with Different Intrinsic Pigments Incorporated by Mechanical and Industrial Methods.

OBJECTIVE: The aim of this study was to evaluate the tear strength of MDX4-4210 and A-2186 silicones with different intrinsic pigments incorporated by mechanical and industrial methods, comparing nonaged and aged groups. MATERIALS AND METHODS: Twenty-four groups were created according to the American Society for Testing and Materials D-624/type C, half nonaged and half aged (n = 10): bronze mechanical MDX4-4210, bronze industrial MDX4-4210, black mechanical MDX4-4210, black industrial MDX4-4210, pink mechanical MDX4-4210, pink industrial MDX4-4210, bronze mechanical A-2186, bronze industrial A-2186, black mechanical A-2186, black industrial A-2186, pink mechanical A-2186, and pink industrial A-2186. All specimens were submitted to tear strength analysis. Data were submitted to the ANOVA and Tukey test (p < 0.05). RESULTS: An increase in the tear strength values was observed only for the bronze and black MDX4-4210, comparing nonaged and aged silicones (p < 0.05), regardless of the manufacturing method. There was a difference in all comparisons between MDX4-4210 and A-2186 silicones with the same pigment type (p < 0.05), regardless of the manufacturing method. In all cases, there was no difference in the manufacturing method comparing the MDX4-4210 or A-2186 groups with the same pigment. CONCLUSION: Accelerated aging did not influence the tear strength in all aged A-2186 silicones and in aged pink industrial and mechanical MDX4-4210 silicones. The other MDX4-4210 groups had an increase in the results after aging. In all cases compared, the A-2186 groups had higher tear strength values than the MDX4-4210 groups. Mechanical and industrial methods can be used for silicone preparation, without changing the tear strength.

Stress distribution of different implant connections associated with multiple implant-supported prostheses.

In some clinical situations, the clinician may encounter previously installed implants that should be associated with other implants for a proper rehabilitation. The aim of this study was to evaluate the biomechanical behaviour of a multiple prosthesis joined by different implant connections using photoelasticity. Photoelastic models with a screwed fixed prosthesis supported by implants with different connection systems (Morse taper, external hexagon, internal hexagon, and Flexcone), and different combinations among them, were fabricated. Each assembly was placed in a circular polariscope, and axial and oblique (45°) loads of 100 N were applied on the occlusal surface of the crowns. The fringe patterns were photographed and the analysis was performed by counting the number of high-intensity fringes and also according to the stress distribution region where they appeared. Among implants of the same connection, the external connections obtained a greater number of high intensity fringes when compared to the internal connections. From the biomechanical point of view, the association between different types of connections obtained positive results.

Clinical outcome of removable prostheses supported by mini dental implants. A systematic review.

INTRODUCTION: For many years, edentulous patients have had no other option than conventional dentures to reestablish their oral function. To avoid the need for bone graft surgery, some professionals have suggested the use of mini dental implants (MDIs) to support prostheses. The MDIs are narrow implants, ranging approximately from 1.8 to 2.9 mm in diameter. Recently, the promising results of mini implants regarding osseointegration and patient satisfaction have led clinicians to accept them as a definitive treatment option. OBJECTIVE: Therefore, the proposition of this systematic review was to assess information on the outcomes of MDIs supporting removable prostheses. METHODS: The PubMed and Cochrane databases were searched for articles published before September 2017, which yielded a total of 774 studies for analysis. After exclusion and inclusion criteria, 22 prospective studies were included in this systematic review. RESULTS: Most mini implants were placed in a flapless single-stage surgery and loaded immediately. Most studies reported failures in the first year and prosthetic complications. The mean survival rate of the selected studies was 95.6%, and mean follow-up was 22.8 months. CONCLUSION: The MDI-supported removable prostheses successfully improved patients' chewing and speaking ability, quality of life, and satisfaction, suggesting that MDIs are a viable and safe option to support removable prostheses in the mandibular arch.

Does the Presence of a Cantilever Influence the Survival and Success of Partial Implant-Supported Dental Prostheses? Systematic Review and Meta-Analysis.

PURPOSE: To investigate if the presence of a cantilever influences the survival and success of partial fixed implant-supported prostheses, through a systematic review and meta-analysis, with additional analysis of the survival and marginal bone loss rates and prosthesis complications. MATERIALS AND METHODS: The register protocol of the review in the PROSPERO database is CRD42016052008. The MEDLINE and Scopus databases were used for an electronic search of relevant studies up to November 2016, by means of two independent reviewers. The keywords included the combinations "fixed partial denture" with "dental implants", and with "extension" or "cantilever"; and "implant-supported dental prosthesis" with "extension" or "cantilever". The inclusion criteria were randomized clinical trials and prospective and retrospective clinical studies in English that addressed the comparison of success and survival of the use of implant-supported fixed prostheses, with and without cantilevers. Data from the selected studies were used to perform the statistical analysis. RESULTS: Among the 408 articles identified, 4 articles met the eligibility criteria. The presence of a cantilever did not compromise marginal bone loss or the survival of the prostheses. However, minor complications were encountered for the group of partial fixed prostheses without cantilevers, with a statistical difference (P = .008). CONCLUSION: Cantilevers can be used in fixed prostheses and do not interfere negatively in the survival or success of the prosthesis or the marginal bone loss. However, there are minor complications when prostheses without cantilevers, or short cantilevers, are used.

Satisfação e qualidade de vida em pacientes desdentados após reembasamento com material resiliente / Installation of implant-supported provisional prosthesis: case report

O objetivo desse trabalho foi avaliar a satisfação e a qualidade de vida de pacientes desdentados que tiveram suas próteses totais mandibulares reembasadas com material resiliente (Ufi Gel SC, VOCO, Alemanha). Foram selecionados 20 pacientes desdentados divididos aleatoriamente nos grupos de reembasamento direto ou indireto (n=10). Foram aplicados dois questionários, o OHIP Edent para avaliar a qualidade de vida e um questionário desenvolvido para verificar a satisfação dos pacientes com o uso do reembasador. Os testes clínicos foram realizados em quatro fases durante o tratamento: inicialmente com as próteses totais sem intervenção, 30, 60 e 90 dias após o reembasamento. A análise de variância ANOVA demonstrou que houve uma diferença estatisticamente significante para o fator tempo tanto para a qualidade de vida como para a satisfação (p d" 0,05). Observamos que a qualidade de visa e a satisfação aumentaram após o reembasamento, mas não houve diferença entre os métodos de polimerização testados. O método de polimerização direto é mais simples, menos demorado e menos oneroso para o paciente. Portanto, se não houver diferença entre os métodos de polimerização a longo prazo, não há porque submeter o paciente ao reembasamento indireto(AU)

The aim of this paper was to assess the quality of life and satisfaction for edentulous individuals who had their complete dentures relined with a soft liner material (Ufi Gel SC, VOCO, Germany). A total of 20 patients were selected and divided into two experimental groups, one for a chairside procedure and one for a laboratorial reline (n=10). Two questionnaires were used, the OHIP Edent and a satisfaction form to assess information on the reline material. The tests were performed initially and at 30, 60 and 90 days after the reline. The analysis of variance ANOVA presented a difference for the period evaluation, the quality of life improved after the procedure, but there was no difference between the polymerization methods. The chairside procedure is more simple, faster and more practical for both, professionals and patients. Therefore, if there are no difference in long term results, there is no reason to the patient undergo the laboratorial reline process(AU)

Avaliação da qualidade de vida, força de mordida e halitose após reembasamento resiliente com diferentes métodos de polimerização / Influence of quality of life, satisfaction, bite force and halitosis after soft reline in edentulous patients, with different polymerization techniques

Os reembasadores resilientes têm sido amplamente utilizados em pacientes portadores de próteses totais para melhorar a adaptação da base de resina ao rebordo. Esses apresentam dois métodos de polimerização, um feito diretamente na boca do paciente e outro feito indiretamente em laboratório. Não há estudos na literatura que avaliem a percepção dos pacientes com relação a esse tratamento. Portanto o objetivo desse trabalho foi avaliar a satisfação a qualidade de vida, força de mordida e halitose de pacientes desdentados que tiveram suas próteses totais mandibulares reembasadas com material resiliente (Ufi Gel SC, Voco, Alemanha). Foram selecionados 20 pacientes desdentados seguindo critérios de inclusão e exclusão predefinidos para terem suas próteses mandibulares reembasadas. Estes foram divididos aleatoriamente nos grupos de reembasamento direto ou indireto (n=10). Os ensaios clínicos verificaram a qualidade de vida (OHIP Edent), a satisfação com o reembasamento, a força de mordida e também presença e etiologia de halitose. Os testes clínicos foram realizados inicialmente com as próteses totais sem intervenção, após o reembasamento, aos 30, 60, 90 e 180 dias após o reembasamento. A análise de variância ANOVA (significância de 5%) demonstrou que houve uma diferença estatisticamente significante para o fator tempo para todos os testes, mas a técnica de reembasamento não. Observamos que a qualidade de vida, a satisfação, a força de mordida e halitose melhoraram após o reembasamento. A halitose foi influenciada pelo reembasamento e pela higiene bucal dos pacientes. Apesar de não ter demonstrado diferença estatisticamente entre os métodos de polimerização, foi um resultado favorável tanto para o clínico como para o paciente. Portanto, se não houver diferença entre os métodos de polimerização a longo prazo, não há porque submeter o paciente ao reembasamento indireto. Independentemente do método de polimerização escolhido, o reembasamento com material resiliente a base de silicone demonstrou ser uma alternativa viável para melhorar os aspectos funcionais e a satisfação em pacientes que apresentem dificuldades em utilizar próteses totais mandibulares(AU)

Resilient reliners have been widely used for patients wearing complete dentures to improve the adaptation of the base. They present two polymerization methods, one done directly in the patient's mouth and another done indirectly in the laboratory. There are no studies in the literature that assess the perception of patients regarding this treatment. Therefore, the purpose of this paper was to assess, the satisfaction, quality of life of edentulous patients who had their total mandibular prostheses rebased with resilient material (Ufi Gel SC, Voco, Germany). 20 edentulous patients were selected according to predefined inclusion and exclusion criteria. These were randomly divided into the direct or indirect soft reline groups (n = 10). The clinical trial evaluated the quality of life (OHIP Edent), the satisfaction regarding the treatment, the bite force and presence and prevalence of halitosis. The assays were performed in six phases during the treatment: initially with the total prostheses without intervention, after the reline procedure, 30, 60, 90 and 180 days after the reline. The analysis of variance ANOVA (5% significance) demonstrated a statistically significant difference for period in all parameters, but the technique did not influence any of the parameters (P ≤ 0.05). We observed that the QoL, satisfaction, bite force and halitosis increased after the reline. The halitosis was influenced by patients' oral hygiene and the reline procedure. Although it has not demonstrated a statistical difference between polymerization methods, it was a favorable result for both clinicians and patients. The direct polymerization method is simpler, less time consuming and less costly for the patient. Therefore, if there is no long-term difference between polymerization methods, there is no need to perform an indirect procedure. Regardless of the method of polymerization chosen, relining with resilient silicone-based material is a viable alternative to improve the quality of life, satisfaction, bite force and halitosis in patients who have difficulties wearing mandibular dentures(AU)

Perception and expectation. What do patients really want from the dental treatment? / Percepção e expectativa. O que os pacientes realmente querem do tratamento dental?

ABSTRACT Objective The aim of this study was to investigate the subjective aspects related to the perception of dental appearance and expectations of patients who receive dental treatment in graduation clinics of the Araçatuba Dental School. Methods It was evaluated 362 patients of both gender aged over 18. The questionnaire included questions of demographic data, questions to assess facial and dental aesthetics, dental satisfaction and treatments considering patients notion to improve dental esthetics. The data collected was analyzed using descriptive statistics and the chi-square test. Results The factor teeth for facial analysis and factor positioning in the arch for smile analysis were considered the most important subjects regarding the esthetic according to the respondents. 67.5% of patients were dissatisfied with the appearance of their teeth, and dissatisfaction with the color was the most important factor (66.8%). The treatment most desired was tooth whitening and 85.0% of patients said yes to it. Conclusion Respondents place great value on the teeth on the face appearance, and it can be seen that aesthetic treatments are highly valued in all age groups. There is a need for treatments to restore the function, but treatments to improve dental appearance were the most requested.

RESUMO Objetivo Avaliar os aspectos subjetivos relacionados à percepção da aparência dental e expectativas de pacientes que recebem tratamento odontológico nas clínicas de graduação da Faculdade de Odontologia de Araçatuba. Métodos Foram avaliados 362 pacientes de ambos os sexos com idade superior a 18. O questionário incluiu perguntas sobre dados demográficos, perguntas para avaliar a estética facial e dentária, a satisfação dental e tratamentos considerando a noção dos pacientes de melhorar a estética dental. Os dados coletados foram analisados por meio de estatística descritiva e o teste do qui-quadrado. Resultados O fator dentes para análise facial e o fator posicionamento no arco para análise sorriso foram considerados os temas mais importantes a respeito da estética, de acordo com os entrevistados. 67,5% dos pacientes estavam insatisfeitos com a aparência de seus dentes, a insatisfação com a cor foi o fator mais importante (66,8%). O tratamento mais desejado foi o clareamento dental e 85,0% dos pacientes disse sim a ele. Conclusão Os pacientes dão grande valor aos dentes sobre a aparência rosto, e ele pode ser visto que os tratamentos estéticos são altamente valorizados em todos os grupos etários. Há uma necessidade de tratamentos para restabelecer a função, mas os tratamentos para melhorar a aparência dentária foram os mais solicitados.

Biomechanical evaluation of spring system for implant-supported prosthesis: analysis by photoelasticity and extensometry.

New systems are released in the odontological market with the objective of bringing improvements and advancements in the clinical success of implants and implant-supported prostheses. The distribution of tension for the bone/implant system of these new systems is important. The purpose of this work was to evaluate, by photoelastic analysis and strain gauges, the distribution of tension for the bone/implant system, using the Slim system. A photoelastic cast with an external hexagon implant was manufactured and a metal prosthesis was screwed below it, with or without the tested system. For the photoelasticity methodology, a photoelastic cast, with or without the tested system, was positioned in a circular polariscope, and axial loads of 100 N were applied to the centre of the crown. The pattern of tension generated was photographed and analysed qualitatively in an imaging programme. For the extensometry methodology, two extensometers were placed in the mesial and distal region of the implant in the photoelastic cast. The axial loads were applied to the group again, with or without the system (n = 10). The t test of independent samples with a significance level of 5% was used for this analysis. This study demonstrated greater tension values for both the photoelastic and extensometry methods when the tested system was used. Clinical studies must be performed to evaluate the tested system because the results might not be clinically significant to a bone reabsorption.

Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.

This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.