ABSTRACT
7-Arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Most of tested compounds showed good antifungal activity. The results suggest that those 5,8-dioxo-5,8-dihydroisoquinolines would be potent antifungal agents.
Subject(s)
Antifungal Agents/pharmacology , Aspergillus/drug effects , Candida/drug effects , Carboxylic Acids/pharmacology , Cryptococcus neoformans/drug effects , Isoquinolines/pharmacology , Antifungal Agents/chemical synthesis , Antifungal Agents/chemistry , Candida/classification , Carboxylic Acids/chemical synthesis , Carboxylic Acids/chemistry , Dose-Response Relationship, Drug , Isoquinolines/chemical synthesis , Isoquinolines/chemistry , Microbial Sensitivity Tests , Molecular Structure , Structure-Activity RelationshipABSTRACT
Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents.
Subject(s)
Antifungal Agents/pharmacology , Carbolines/chemical synthesis , Chemistry, Pharmaceutical/methods , Aspergillus flavus/metabolism , Aspergillus niger/metabolism , Candida albicans/metabolism , Carbolines/pharmacology , Drug Design , Fungi/drug effects , Indoles/chemistry , Microbial Sensitivity Tests , Models, Chemical , Saccharomyces cerevisiae/metabolism , Time FactorsABSTRACT
Benzofuran-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many benzofuran-5-ols showed good antifungal activity. The results suggest that benzofuran-5-ols would be promising antifungal agents.
Subject(s)
Antifungal Agents/chemical synthesis , Antifungal Agents/pharmacology , Benzofurans/chemical synthesis , Benzofurans/pharmacology , Aspergillus/drug effects , Candida/drug effects , Cryptococcus neoformans/drug effects , Microbial Sensitivity TestsABSTRACT
Benzo[d]oxazole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that benzo[d]oxazole-4,7-diones would be potent antifungal agents.
