Homonymous Quadrantanopsia as the First Manifestation of Cerebral Metastasis of Invasive Mole: a case report.

INTRODUCTION: Homonymous quadrantanopsia results from retrochiasmal lesions in the visual pathway. Invasive mole is a benign tumor that arises from myometrial invasion of a hydatidiform mole via direct extension through tissue or venous channels. Cerebral metastasis of invasive mole is rare and there has been no report demonstrating homonymous quadrantanopsia as the first manifestation of metastasis in any trophoblastic neoplasms. CASE PRESENTATION: We report the case of a 31-year-old Asian woman who presented with right homonymous inferior quadrantanopsia from the mass effect of a solitary cerebral metastasis from an invasive mole. A magnetic resonance image (MRI) of the brain showed a metastatic tumor in the left occipital lobe. The visual field improved slightly after chemotherapy. There was a reduction in the tumor size and the surrounding edema. This is the first case report demonstrating that homonymous quadrantanopsia should be included in the manifestations of the metastasis of an invasive mole. CONCLUSIONS: The presentation of homonymous quadrantanopsia must alert ophthalmologists to conduct a complete medical history and arrange specialist consultation.

[Application of Octopus 101 automated perimetry with kinetic and static program in patients with the anterior ischemic optic neuropathy].

OBJECTIVE: To investigate the clinical significance of the Octopus 101 kinetic and Static combined automatic perimetry in Anterior Ischemic Optic Neuropathy (AION). To assess the merit and demerit of Octopus 101 kinetic and static combined automatic perimetry performed in AION cases. METHODS: 45 AION patients were detected with Octopus 101 with kinetic and static 30 degrees, 60 degrees scope static program from June 2006 to September 2008. The mean defect (MD), loss variance (LV), areas of isopter, and reaction time were analyzed. The correlation between MD, areas of isopter and reaction time were analyzed. RESULTS: In AION, there are kinds of visual field defect related to the optic lesions in static perimetry examine. Kinetic programme display the isopter deletion. Isopter areas using I-2e and III-4e stimulus are significantly different (P < 0.05). Smaller stimulus can find more periphery changes in AION. CONCLUSIONS: The Octopus 101 perimeter can provide static and kinetic program in the same sitting. In clinical practice it is necessary to perform both static and kinetic examination in patients with AION because the visual field defects are diverse, and the data provided by static and kinetic program are complementary.

[Research advancement of optic nerve injury therapy by transgenic expression neurotrophic factors].

Optic nerve injury is one of factors leading to blindness, and the effective therapy is still not available in clinic. The neurotrophic factors (NTF) can significantly enhance the survival of retinal ganglion cells (RGC) and the regeneration of axonal but showed a short-term effect in vivo. The continue expression of NTF by transgenic technology could overcome this disadvantage, which may provide a new therapeutic approach for the optic nerve injury. We reviewed the articles regarding the research progress of transgenic technology in the treatment of optic nerve injure by NTF recently.