ABSTRACT
Wedge biopsies of liver from 155 patients with advanced schistosomiasis japonica were observed pathologically, and HBsAg and HBcAg in liver were tested with double bridge peroxidase-anti-peroxidase (PAP) method. 88 of 155 cases (56.8%) were found to be HBsAg and/or HBcAg (HBAg) positive in liver. Eosinophilic intranuclear inclusions were observed in the hepatocytes of 30 cases (19.4%), in which 18 (60%) were also HBAg positive in liver. These inclusions were considered to be the markers of several virus infections, such as cytomegalovirus, herpes simplex virus, etc. The patients with positive HBAg and/or inclusion in liver had significantly more severe pathological changes in liver parenchyma. The results indicate that in addition to hepatitis B, complication with other viral infections in liver, which produce eosinophilic intranuclear inclusion, may also aggravate the pathological changes in liver and may be one of the causes of portal cirrhosis in patients with advanced schistosomiasis japonica (Fig. 1). schistosomiasis japonica
